Dexamethasone Solution
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Questions & Answers
Side Effects & Adverse Reactions
Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.
Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have produced cleft palate. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs which received corticosteroids during pregnancy.
A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Dexamethasone is indicated for the treatment of primary bovine ketosis and as an anti-inflammatory agent in the bovine and equine.
As supportive therapy, Dexamethasone may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids. Dexamethasone may be used intravenously as supportive therapy when an immediate hormonal response is required.
Bovine Ketosis
Dexamethasone is offered for the treatment of primary ketosis. The gluconeogenic effects of Dexamethasone, when administered intramuscularly, are generally noted within the first 6 to 12 hours. When Dexamethasone is used intravenously, the effects may be noted sooner. Blood sugar levels rise to normal levels within 12 to 24 hours. Acetone bodies are reduced to normal concentrations usually within 24 hours. The physical attitude of animals and appetite improves, usually within 12 hours. Milk production, which is suppressed as a compensatory reaction in this condition, begins to increase. In some instances, it may even surpass previous peaks. The recovery process usually takes from 3 to 7 days.
Supportive Therapy
Dexamethasone may be used a supportive therapy in mastitis, metritis, traumatic gastritis, and pyelonephritis, while appropriate primary therapy is administered. In these cases, the corticosteroid combats accompanying stress and enhances the feeling of general well-being.
Dexamethasone may also be used as supportive therapy in inflammatory conditions such as arthritic conditions, snake bite, acute mastitis, shipping fever, pneumonia, laminitis, and retained placenta.
Equine
Dexamethasone is indicated for the treatment of acute musculoskeletal inflammations, such as bursitis, carpitis, osselets, tendonitis, myositis, and sprains. If boney changes exist in any of these conditions, joints, or accessory structures, a response to Dexamethasone cannot be expected. In addition, Dexamethasone may be used as supportive therapy in fatigue, heat exhaustion, influenza, laminitis, and retained placenta provided that the primary cause is determined and corrected.
History
There is currently no drug history available for this drug.
Other Information
Dexamethasone Solution is a synthetic analogue of prednisolone, having similar but more potent anti-inflammatory therapuetic action and diversified hormonal and metabolic effects. Modification of the basic corticoid structure as achieved in Dexamethasone offers enhanced anti-inflammatory effect compared to older corticosteroids. The dosage of Dexamethasone required is markedly lower than that of prednisone and prednisolone.
Dexamethasone is not species-specific; however, the veterinarian should read the sections on INDICATIONS, DOSAGE, SIDE EFFECTS, CONTRAINDICATIONS, PRECAUTIONS, and WARNINGS before this drug is used. Dexamethasone is intended for intravenous or intramuscular adiminstration.
Each mL contains 2 mg dexamethasone, 500 mg propylethylene glycol 400, 9 mg benzyl alcohol, 1.8 mg methylparaben and 0.2 mg propylparaben as preservatives, 4.75% alcohol, HCl to adjust pH to approximately 4.9, water for injection q.s.
Sources
Dexamethasone Solution Manufacturers
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Mwi/vetone
![Dexamethasone Solution (Dexamethasone) Solution [Mwi/vetone]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Dexamethasone Solution | Mwi/vetone
Therapy with Dexamethasone, as with any other potent corticosteroid, should be individualized accordingly to the severity of the condition being treated, anticipated duration of steroid therapy, and animal's threshold or tolerance for steroid excess. Treatment may be changed over to Dexamethasone from any other glucocorticoid with proper reduction or adjustment of dosage.
Bovine: Dexamethasone 5-20mg intravenously or intramuscularly. Equine: Dexamethasone 2.5-5mg intravenously or intramuscularly.
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Bryant Ranch Prepack
Dexamethasone Solution | Bryant Ranch Prepack
There is currently no dosage information available for this product. We apologize for any inconvenience.
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Med-pharmex, Inc
Dexamethasone Solution | Med-pharmex, Inc
ADMINISTRATION AND DOSAGE:
Therapy with Dexamethasone Solution, as with any other potent corticosteroid, should be individualized according to the severity of the condition being treated, anticipated duration of steroid therapy, and animal's threshold or tolerance for steroid excess.Treatment may be changed over to Dexamethasone Solution from any other glucocorticoid with proper reduction or adjustment of dosage.
Bovine - Dexamethasone Solution - 5 to 20 mg intravenously or intramuscularly. The parenteral dose may be repeated as needed.
Equine - Dexamethasone Solution - 2.5 to 5 mg intravenously or intramuscularly. The parenteral dose may be repeated as needed.
![Dexamethasone Solution [Bryant Ranch Prepack]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=0e459fc9-ea95-475f-b1d1-b2578366c632&name=26961.jpg)
![Dexamethasone Solution Injection, Solution [Med-pharmex, Inc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=64e94dba-1f78-47e3-aad5-d637d30148c9&name=DexamethasoneSolution2mg_mL.jpg)
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