Gonabreed

Gonabreed

Gonabreed Recall

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Questions & Answers

Side Effects & Adverse Reactions

There is currently no warning information available for this product. We apologize for any inconvenience.

Legal Issues

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FDA Safety Alerts

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Manufacturer Warnings

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FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

INDICATIONS AND DOSAGE:

Cystic Ovaries

GONAbreed is indicated for the treatment of ovarian follicular cysts in dairy cattle. Ovarian cysts are non-ovulated follicles with incomplete luteinization which result in nymphomania or irregular estrus.

Historically, cystic ovaries have responded to an exogenous source of luteinizing hormone (LH) such as human chorionic gonadotrophin. GONAbreed initiates release of endogenous LH to cause ovulation and luteinization.

The recommended intravenous or intramuscular dosage of GONAbreed is 100 mcg (1 mL) per cow.

Reproductive Synchrony

GONAbreed is indicated for use with cloprostenol sodium to synchronize estrous cycles to allow for fixed time artificial insemination (FTAI) in lactating dairy cows and beef cows.

The recommended intramuscular dosage of GONAbreed is 100 mcg (1 mL) per cow, used in reproductive synchrony programs similar to the following:

  • Administer the first GONAbreed injection (1 mL) at Time 0.
  • Administer 500 mcg cloprostenol (as cloprostenol sodium) by intramuscular injection 6 to 8 days after the first GONAbreed injection.
  • Administer the second GONAbreed injection (1 mL) 30 to 72 hours after the cloprostenol sodium injection.
  • Perform FTAI 0 to 24 hours after the second GONAbreed injection, or inseminate cows on detected estrus using standard herd practices.

History

There is currently no drug history available for this drug.

Other Information

DESCRIPTION:

GONAbreed is a sterile solution containing 100 micrograms of gonadorelin (GnRH) as gonadorelin acetate per milliliter suitable for intramuscular or intravenous administration according to the indication. Gonadorelin is a decapeptide composed of the sequence of amino acids –

5-oxoPro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

a molecular weight of 1182.32 and empirical formula C55H75N17O13. The acetate salt has a molecular weight of 60.05 and an empirical formula C55H75N17O13. C2H4O2.

Gonadorelin is the hypothalamic releasing factor responsible for the release of gonadotropins (e.g., LH, FSH) from the anterior pituitary. Synthetic gonadorelin is physiologically and chemically identical to the endogenous bovine hypothalamic releasing factor.

Gonabreed Manufacturers


  • Parnell Technologies Pty Ltd
    Gonabreed (Gonadorelin Acetate) Injection, Solution [Parnell Technologies Pty Ltd]

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