Levophed

Levophed

Levophed Recall

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Questions & Answers

Side Effects & Adverse Reactions

LEVOPHED should be used with extreme caution in patients receiving monoamine oxidase inhibitors (MAOI) or antidepressants of the triptyline or imipramine types, because severe, prolonged hypertension may result.

LEVOPHED Bitartrate Injection contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

For blood pressure control in certain acute hypotensive states (e.g., pheochromocytomectomy, sympathectomy, poliomyelitis, spinal
anesthesia, myocardial infarction, septicemia, blood transfusion, and drug reactions).
As an adjunct in the treatment of cardiac arrest and profound hypotension.

History

There is currently no drug history available for this drug.

Other Information

Rx Only


Norepinephrine (sometimes referred to as l-arterenol/Levarterenol or l-norepinephrine) is a sympathomimetic amine which differs from epinephrine by the absence of a methyl group on the nitrogen atom. Norepinephrine Bitartrate is (-)-a-(aminomethyl)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate and has the following structural formula:

Formula1

LEVOPHED is supplied in sterile aqueous solution in the form of the bitartrate salt to be administered by intravenous infusion following dilution. Norepinephrine is sparingly soluble in water, very slightly soluble in alcohol and ether, and readily soluble in acids. Each mL contains the equivalent of 1 mg base of norepinephrine, sodium chloride for isotonicity, and not more than 2 mg of
sodium metabisulfite as an antioxidant. It has a pH of 3 to 4.5. The air in the ampuls has been displaced by nitrogen gas.


Levophed Manufacturers


  • General Injectables & Vaccines, Inc
    Levophed (Norepinephrine Bitartrate) Injection, Solution, Concentrate [General Injectables & Vaccines, Inc]
  • Hospira, Inc.
    Levophed (Norepinephrine Bitartrate) Injection, Solution, Concentrate [Hospira, Inc.]
  • Hospira, Inc.
    Levophed (Norepinephrine Bitartrate) Injection, Solution, Concentrate [Hospira, Inc.]
  • Cardinal Health
    Levophed (Norepinephrine Bitartrate) Injection, Solution, Concentrate [Cardinal Health]
  • Hospira, Inc.
    Levophed (Norepinephrine Bitartrate) Injection, Solution, Concentrate [Hospira, Inc.]
  • Hospira, Inc.
    Levophed (Norepinephrine Bitartrate) Injection, Solution, Concentrate [Hospira, Inc.]

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