Sodium Bicarbonate Solution
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Questions & Answers
Side Effects & Adverse Reactions
There is currently no warning information available for this product. We apologize for any inconvenience.
Legal Issues
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FDA Safety Alerts
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Manufacturer Warnings
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FDA Labeling Changes
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Uses
Sodium Bicarbonate 4.2% Neutralizing Additive Solution is indicated for use as a neutralizing solution to raise the pH of acid solutions administered intravenously to reduce the incidence of chemical phlebitis and patient discomfort due to vein irritation at or near the site of infusion.
History
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Other Information
Sodium Bicarbonate 4.2% Neutralizing Additive Solution is a sterile, nonpyrogenic solution of sodium bicarbonate in Water for Injection. It is administered by the intravenous route only after addition as a neutralizing agent to an acidic large volume parenteral solution.
Each mL contains: Sodium bicarbonate 42 mg (0.5 mEq each of Na+ and HCO3–). Total sodium (Na+) content of each 5 mL is 57.5 mg (11.5 mg/mL). pH adjusted with carbon dioxide and as a result, pressure may be present.
The solution contains no bacteriostat, antimicrobial agent or added buffer. pH 7.0–8.5 and the osmolar concentration is 1 mOsmol/mL.
Sodium Bicarbonate, USP is chemically designated as NaHCO3, a white crystalline powder soluble in water.
Sources
Sodium Bicarbonate Solution Manufacturers
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App Pharmaceuticals, Llc
![Sodium Bicarbonate Solution [App Pharmaceuticals, Llc]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Sodium Bicarbonate Solution | App Pharmaceuticals, Llc
One vial (5 mL) of Sodium Bicarbonate 4.2% Neutralizing Additive Solution added to a liter (1,000 mL) of any of the following parenteral solutions will increase the pH to a more physiologic range. Specific pH may vary slightly from lot to lot.
5% Alcohol and D5-W
5% Dextrose and Ringer’s
5% Dextrose and 0.45% Sodium Chloride Injection, USP
2.5% Dextrose and 0.45% Sodium Chloride Injection, USP
5% and 0.225% Sodium Chloride Injection, USP
5% Dextrose and 0.9% Sodium Chloride Injection, USP
2.5% Dextrose Injection, USP
5% Dextrose Injection, USP
10% Dextrose Injection, USP
20% Dextrose Injection, USP
10% Invert Sugar
Lactated Ringer’s
Ringer’s Injection
0.9% Sodium Chloride Injection, USP
0.45% Sodium Chloride Injection, USP
Sodium Lactate 1/6 Molar
NOTE: Some products such as amino acid solutions and multiple electrolyte solutions
containing dextrose will NOT be brought to near physiologic pH by the addition of
Sodium Bicarbonate 4.2% Neutralizing Additive Solution. This is due to the relatively
high buffer capacity of these fluids.
COMPATIBILITY AND EFFECTIVENESS OF SODIUM BICARBONATE 4.2% NEUTRALIZING ADDITIVE SOLUTION WITH ADDITIVES TO
5% DEXTROSE INJECTION (D5-W)When medications are added to intravenous solutions, the resultant admixture may or may not be compatible in solutions containing Sodium Bicarbonate 4.2% Neutralizing Additive Solution. (See Compatibility section under Sodium Bicarbonate in Handbook on Injectable Drugs by Lawrence A. Trissel.)
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
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Sagent Pharmaceuticals
Sodium Bicarbonate Solution | Sagent Pharmaceuticals
There is currently no dosage information available for this product. We apologize for any inconvenience.
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Onpharma, Inc.
Sodium Bicarbonate Solution | Onpharma, Inc.
The practitioner should choose a volume of Sodium Bicarbonate Inj., 8.4% USP Neutralizing Additive Solution to be mixed with Lidocaine w/ Epinephrine in a ratio of 1:10 (local anesthetic solution to sodium bicarbonate solution).
The below table provides a mixing guide showing for convenience the volumes of 8.4% Sodium Bicarbonate Neutralizing Additive Solution to be added to the commercial preparations of Lidocaine with Epinephrine in order to achieve a mixed ratio of 10:1.10:1 Anesthetic-to-Bicarbonate Solution Ratio Mixing Guide for 10:1
Volume (mL), Lidocaine w/ Epinephrine (container type) Volume (mL), 8.4% Sodium Bicarbonate Solution 1.8 mL (cartridge) 0.18 mL 20 mL (Vial) 2.0 mL 30 mL (Vial) 3.0 mL 50 mL (Vial) 5.0 m
![Sodium Bicarbonate Solution [Sagent Pharmaceuticals]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=fac2b99f-25aa-4a97-98b4-431f1c338885&name=sod08-0000-01.jpg)
![Sodium Bicarbonate Solution [Onpharma, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=f9c826a7-8f19-4857-b5be-11dcafcfc7a9&name=27carton.jpg)
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