Ista Pharmaceuticals, Inc

Ista Pharmaceuticals, Inc Drugs

• Istalol
  

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  Istalol

  

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  ISTALOL ophthalmic solution is available in a concentration of 0.5 percent. The starting dose is one drop of 0.5 percent ISTALOL in the affected eye(s) once a day in the AM. If the patient's intraocular pressure is not at a satisfactory level on this regimen, concomitant therapy with other agent(s) for lowering intraocular pressure can be instituted. The concomitant use of two topical beta-adrenergic blocking agents is not recommended. (See PRECAUTIONS, Drug Interactions, Beta-adrenergic blocking agents.)

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• Vitrase
  

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  Vitrase

  

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  Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

  VITRASE (hyaluronidase injection) should be administered as discussed below, since its effects relative to absorption and dispersion of other drugs are not produced when it is administered intravenously.  Draw the desired amount of VITRASE into the syringe to obtain the target Hyaluronidase Activity (USP Units) according to the table below.

   

  Amount of VITRASE Solution Withdrawn Per Target Hyaluronidase Activity Target Hyaluronidase Activity (USP Units) Volume Withdraw from Vial (mL) 50 Units 0.25 mL 75 Units 0.38 mL 150 Units 0.75 mL 200 Units 1.0 mL

  After admixture with drug, store at 15-25°C (59-77°F) and use within 6 hours.

  2.1 Subcutaneous Fluid Administration (Hypodermoclysis)

  Insert needle with aseptic precautions.  With tip lying free and movable between skin and muscle, begin clysis; fluid should start in readily without pain or lump.  Then inject VITRASE (hyaluronidase injection) into rubber tubing close to needle.An alternate method is to inject VITRASE under skin prior to clysis.  200 Units will facilitate absorption of 1,000 mL or more of solution.  As with all parenteral fluid therapy, observe effect closely, with same precautions for restoring fluid and electrolyte balance as in intravenous injections.  The dose, the rate of injection, and the type of solution (saline, glucose, Ringer’s etc.) must be adjusted carefully to the individual patient.  When solutions devoid of inorganic electrolytes are given by hypodermoclysis, hypovolemia may occur.  This may be prevented by using solutions containing adequate amounts of inorganic electrolytes and/or controlling the volume and speed of administration.VITRASE may be added to small volumes of solution (up to 200 mL), such as small clysis for infants or solutions of drugs for subcutaneous injection.  For infants and children less than 3 years old, the volume of a single clysis should be limited to 200 mL; and in premature infants or during the neonatal period, the daily dosage should not exceed 25 mL/kg of body weight; the rate of administration should not be greater than 2 mL per minute. For older patients, the rate and volume of administration should not exceed those employed for intravenous infusion.

   

  2.2 Absorption and Dispersion of Injected Drugs

  Absorption and dispersion of other injected drugs may be enhanced by adding 50 – 300 Units, most typically 150 Units of VITRASE hyaluronidase to the injection solution.  

   

  2.3 Subcutaneous Urography

  The subcutaneous route of administration of urographic contrast media is indicated when intravenous administration cannot be successfully accomplished, particularly in infants and small children. With the patient prone, 75 Units of VITRASE (hyaluronidase injection) is injected subcutaneously over each scapula, followed by injection of the contrast medium at the same sites.

   

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• Bromday
  

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  Bromday

  

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  2.1 Recommended Dosing

  For the treatment of postoperative inflammation in patients who have undergone cataract extraction, one drop of Bromday ophthalmic solution should be applied to the affected eye(s) once daily beginning 1 day prior to cataract surgery, continued on the day of surgery, and through the first 14 days of the postoperative period.

  2.2 Use with Other Topical Ophthalmic Medications

  Bromday ophthalmic solution may be administered in conjunction with other topical ophthalmic medications such as alpha-agonists, beta-blockers, carbonic anhydrase inhibitors, cycloplegics, and mydriatics. Drops should be administered at least 5 minutes apart.

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• Bepreve
  

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  Bepreve

  

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  Instill one drop of BEPREVE into the affected eye(s) twice a day (BID).

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