Preferred Pharmaceuticali Inc.

Preferred Pharmaceuticali Inc. Drugs

• Cefuroxime Axetil
  

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  Cefuroxime Axetil

  

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  NOTE: CEFUROXIME AXETIL TABLETS AND CEFUROXIME AXETIL FOR ORAL SUSPENSION ARE NOT BIOEQUIVALENT AND ARE NOT SUBSTITUTABLE ON A MILLIGRAM-PER-MILLIGRAM BASIS (SEE CLINICAL PHARMACOLOGY).

  Table 9. Cefuroxime Axetil Tablets (May be administered without regard to meals.) aThe safety and effectiveness of cefuroxime axetil tablets administered for less than 10 days in patients with acute exacerbations of chronic bronchitis have not been established.

  Population/Infection

  Dosage

  Duration(days)

     Adolescents and Adults (13 years and older)

        Pharyngitis/tonsillitis

  250 mg twice daily

  10

        Acute bacterial maxillary sinusitis

  250 mg twice daily

  10

        Acute bacterial exacerbations of chronic bronchitis

  250 or 500 mg twice daily

  10a

        Secondary bacterial infections of acute bronchitis

  250 or 500 mg twice daily

  5 to 10

        Uncomplicated skin and skin‑-structure infections

  250 or 500 mg twice daily

  10

        Uncomplicated urinary tract infections

  250 mg twice daily

  7 to 10

        Uncomplicated gonorrhea

  1,000 mg once daily

  single dose

        Early Lyme disease

  500 mg twice daily

  20

     Pediatric Patients (who can swallow tablets whole)

        Acute otitis media

  250 mg twice daily

  10

        Acute bacterial maxillary sinusitis

  250 mg twice daily

  10

  Patients With Renal Impairment

  Because cefuroxime is eliminated primarily by the kidney, a dosage interval adjustment is required for patients whose creatinine clearance is <30 mL/min, as listed in Table 11.  

  Table 11. Dosing in Patients with Renal Impairment

  Creatinine Clearance (mL/min)

  Recommended Dosage

  ≥30

  No dosage adjustment

  10 to <30

  Standard individual dose given every 24 hours

  <10 (without hemodialysis)

  Standard individual dose given every 48 hours

  Hemodialysis

  A single additional standard dose should be given at the end of each dialysis

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