Amersham Health Inc.

Amersham Health Inc. Drugs

• Hypaque Sodium
  

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  Hypaque Sodium

  

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  Preparation of the patient will vary with preference of the radiologist and the type of radiological procedure performed. Specific radiographic procedures used will depend on the state of the patient and the diagnostic indications. Individual dose should be tailored according to age, body size, and indication for examination. (See INDIVIDUAL INDICATIONS AND USAGE section for specific Dosage and Administration.)

  Solutions of radiopaque diagnostic agents for intravascular use should be at body temperature when injected and may need to be warmed before use. In the event that crystallization occurs, the solution may be clarified by placing the vial in a water bath at 40°C to 50°C and shaking it gently for two to three minutes or until the solids redissolve. If the particles still persist, do not use this vial but discard it. The solution should be protected from light and any unused portion remaining in the container should be discarded.

  Dilution and withdrawal of the contrast agents should be accomplished under aseptic conditions with sterile syringes.

  Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Avoid contaminating catheters, syringes, needles, and contrast media with glove powder or cotton fibers.

  Pediatric Dosage

  Pediatric doses of injectable radiopaque diagnostic agents are generally determined on a weight basis and should be calculated for each patient individually. (See INDIVIDUAL INDICATIONS AND USAGE section.)

  Drug Incompatibilities

  Diatrizoate salts are incompatible in vitro with some antihistamines and many other drugs. It is believed that one of the chief causes of in vitro incompatibility is an alteration of pH. Turbidity of solutions of intravascular contrast medium occurs between pH 2.5 and 4.1. Another cause is chemical interaction; therefore, other pharmaceuticals should not be mixed with contrast agents in the same syringe.

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• Hypaque – Cysto
  

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  Hypaque – Cysto

  

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  After the bladder is emptied, HYPAQUE-CYSTO is gently instilled without force, often beyond the first desire to micturate, but not beyond the point of urgency or mild discomfort. The volume required to fill the bladder to slightly less than capacity may vary from patient to patient.

  Bladder capacity in normal adults is generally 200 mL to 300 mL, and rarely, up to 600 mL. Capacity at birth is 20 mL to 50 mL, and increases about 400 percent in the first year. In children 3 to 5 years old, bladder capacity is 150 mL to 180 mL. In children older than 8 years, it is in the low adult range.

  In disease, bladder capacity in adults may vary from 50 mL in a hypertonic reflex bladder to over 1000 mL in an atonic or sensory paralytic bladder or chronic lower urinary tract obstruction.

  Repeat examination may be required to detect reflux, or in function studies.

  The concentration varies with technique and equipment used. HYPAQUE-CYSTO may be diluted with sterile water or 5 percent dextrose solution, as indicated in the following table. A 10 percent solution is isotonic.

  STANDARD PACKAGE (250 mL of HYPAQUE-CYSTO in 500 mL bottle) TO MAKE ADD FINAL SOLUTION CONTAINS Final conc. Final volume Sterile water or 5% dextrose solution Iodine 30% 250 mL _ 141 mg/mL 25% 300 mL 50 mL 118 mg/mL 21.4% 350 mL 100 mL 101 mg/mL 20% 375 mL 125 mL 94 mg/mL 18.8% 400 mL 150 mL 88 mg/mL 16.7% 450 mL 200 mL 78 mg/mL 15% 500 mL 250 mL 71 mg/mL

  Note: To achieve the following concentrations some of the contrast agent must be removed prior to dilution.

  TO MAKE REMOVE ADD FINAL SOLUTION CONTAINS Final conc. Final volume Sterile water or 5% dextrose solution Iodine 12% 500 mL 50 mL 300 mL 56 mg/mL 12% 375 mL 100 mL 225 mL 56 mg/mL 10% 450 mL 100 mL 300 mL 47 mg/mL

  Dilution and withdrawal of the contrast agent should be accomplished under aseptic conditions with sterile syringes. The solution should be inspected visually for particulate matter and discoloration prior to administration.

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