Ge Healthcare, Medi-physics, Inc.
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Ge Healthcare, Medi-physics, Inc. Drugs
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![Indium Dtpa In 111 (Indium In-111 Pentetate Disodium) Solution [Ge Healthcare, Medi-physics, Inc.]](http://recallguide.cwdevelopsp.com/wp-content/themes/recallguide/assets/img/drug-image-placeholder.jpg)
Indium Dtpa In 111
Extreme care must be exercised to assure aseptic conditions in intrathecal injections.
The maximum recommended intrathecal dose in the average patient (70 kg) is 18.5 MBq, 500 µCi. The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
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Thallous Chloride Tl 201
The recommended adult (70 kg) dose of Thallous Chloride Tl 201 Injection is 37-74 MBq (1-2 mCi). Thallous Chloride Tl 201 Injection is intended for intravenous administration only.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.
Aseptic procedures should be employed in the withdrawal of the dose for patient administration.
For resting thallium studies, imaging should begin 10-20 minutes after injection. Myocardial-to-background ratios are improved when patients are injected upright and in the fasting state; the upright position reduces the hepatic and gastric Thallium Tl 201 concentration.
When utilized in conjunction with exercise stress testing, Thallous Chloride Tl 201 Injection should be administered at the inception of a period of maximum stress which is sustained for approximately 30 seconds after injection. Imaging should begin within 10 minutes after administration to obtain maximum target-to-background ratios. Several investigators have reported that within two hours after the completion of stress testing the target-to-background ratios may decrease significantly in lesions that are attributable to transient ischemia.
For the localization of parathyroid hyperactivity, Thallous Chloride Tl 201 may be administered before, with or after a minimal dose of a thyroid imaging agent such as sodium pertechnetate Tc99m or sodium iodide I 123 to enable thyroid subtraction imaging.
RADIATION DOSIMETRY
The estimated absorbed doses at calibration time to an average patient (70 kg) from an intravenous injection of a maximum dose of 74 MBq, 2 mCi of Thallous Chloride Tl 201 Injection are shown in Table 4.
Table 4. Radiation Dose Estimates of Thallous Chloride Tl 201 Injection: Absorbed Dose/74 MBq, 2 mCi Thallium Tl 201 Administered* Tissue mGy/74 MBq Rads/2 mCi * Values listed include an average maximum correction of 8% to the radiation doses from Thallous Chloride Tl 201 Injection due to the radiocontaminants Thallium Tl 200 and Thallium Tl 202 at calibration time. Heart Wall 10.0 1.0 Liver 12.0 1.2 Kidneys 24.0 2.4 Testes 11.0 1.1 Ovaries 9.6 0.96 Thyroid 9.6 0.96 Gastrointestinal Tract: Stomach Wall 8.2 0.82 Small Intestine 7.8 0.78 Upper Large Intestine Wall 5.2 0.52 Lower Large Intestine Wall 4.4 0.44 Total Body 4.4 0.44 -
Sodium Iodide
The recommended oral dose range for diagnostic studies of thyroid function in the average adult patient (70 kg) is 3.7-14.8 MBq (100-400 µCi) of Sodium Iodide I-123. The lower portion of the range 3.7 MBq (100 µCi) is recommended for uptake studies alone, and the higher portion 14.8 MBq (400 µCi) for thyroid imaging.
Concentration of I-123 in the thyroid gland should be measured in accordance with standardized procedures. Consideration should be given to the use of proper instrumentation in thyroid imaging with Sodium Iodide I-123. The determination of I-123 concentration in the thyroid gland may be initiated at six hours after administration of the dose.
Use contents of the capsule up to 24 hours after calibration time and date. Thereafter, discard the capsule with its contents. The user should wear waterproof gloves at all times when handling the capsule.
The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.
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