Genpak Solutions Llc

Genpak Solutions Llc Drugs

• Anodynerx
  

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  Anodynerx

  

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  AnodyneRx patch contains 5.00% menthol, 2.5% lidocaine and 0.05% capsaicin.

  Directions:

  Adults and children 12 years and over                          Apply to affected area

  Children under 12 years                                              Consult physician before use

  Instructions for use:

  Clean and dry affected area. Remove patch from backing and apply to affected area. Use only one patch at a time, and a maximum of 3 patches per day. Leave patch on affected area for up eight hours. Reseal pouch containing unused patches. Children under 12 should consult a physician prior to use. Wash hands with soap and water after use.

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• Methotrexate Sodium
  

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  Methotrexate Sodium

  

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  DOSAGE AND ADMINISTRATION

  Neoplastic Diseases

  Oral administration in tablet form is often preferred when low doses are being administered since absorption is rapid and effective serum levels are abtained.

  Choriocarcinoma and similar trophoblastic diseases: Methotrexate is administered orally or intramuscularly in doses 15 to 30 mg daily for a five-day course. Such courses are usually repeated 3 to 5 times as required, with rest periods of one or more weeks interposed between courses, until any manifesting toxic symptoms subside. the effectiveness of therapy is ordinarily evaluated by 24 hour quantitative analysis of urinary chorionic gonadotropin (hCG), which should return to normal or less than 50IC/24hr usually after the third or fourth course and usually be followed by a complete resolution of measurable lesions in 4 to 6 weeks. One to two courses of methotrexate after normalization of hCG is usually recommended. Before each course of the drug careful assessment is essential. Cyclic combination therapy of methotrexate with other antitumor drugs has been recommended.

  Since hydatidiform mole may precede choriocarcinoma, prophylactic chemotherapy with methotrexate has been recommended.

  Chrioadenoma destruens is considered to be an invasive form of hydatidiform mole. Methotrexate is administered in these disease states in doses similar to those recommended for choriocarcinoma.

  Leukemis: Acute lymphoblastic leukemia in pediatric patients and young adolescents is the most responsive to present day chemotherapy. In young adults and older patients, clinical remission is more difficult to obtain and early relapse is more common.

  Methotrexate alone or in a combination with steroids was used initially for induction of remission in acute lymphoblastic leukemias. More recently corticosteroid therapy, in combination with other antileukemic drugs or in cyclic combinations with methotrexate included, has appeared to produce rapid and effective remissions. When used for induction, methotrexate in doses of 3.3 mg/m2 in combination with 60 mg/m2 of prednisone, given daily, produced remissions in 50% of patients treated, usually within a period of 4 to 6 weeks. Methotrexate in combination with other agents appears to be the drug of choice for securing maintenance of drug-induced remissions. When remission is achieved and supportive care has produced general clinical improvement, maintenance therapy is initiated, as follows: Methotrexate is administered 2 times weekly either by mouth or intramuscularly in total weekly doses of 30 mg/m2. it has also been given in doses of 2.5 mg/kg intravenously every 14 days. If and when relapse does occur, reinduction of resission can again usually be obtained by repeating the initial regimen.

  A variety of combination chemotherapy regimens have been used for both induction and maintenance therapy in acute lymphoblastic leukemia. The physician should be familiar with the new advances in antileukemic therapy.

  Lymphomas: In Burkitt's tumor, Stages I-II, methotrexate has produced prolonged remissions in xome cases. Recommended dosage is 10 to 25 mg/day orally for 4 to 8 days. In Stage III, methotrexate is commonly given concomitantly with other antitumor agents. Treatment in all stages usually consists of several courses of the drug interposed with 7 to 10 day rest periods. Lymphosarcomas in Stage III may respond to combination drug therapy with methotrexare given in doses of 0.625 to 2.5 mg/kg daily.

  Mycosis Fungoides (cutaneous T cell lymphoma): Therapy with methotrexate as a single agent appears to produce clinical responses in up to 50% of patients treated. Dosage in the early stages is usually 5 to 50 mg once weekly. Dose reduction or cessation is guided by patient response and hematologic monitoring. Methotrexate has also been administered twice weekly in doses ranging from 15 to 37.5 mg in patients who have responded poorly to weekly therapy.

  Psoriasis, Rheumatiod artiritis, and Juvenile Rheumatoid Atrihritis: The recommeded starting dose is 10 mg/m2 given once weekly.

  For either adult RA or polyarticular-course JRA dosages may be adjusted gradually to achieve an optimal response. Limited experience shows a significant increase in the incidence and severity of serious toxic reactions, especially bone marrow suppression, at doses greater than 20 mg/wk in adults. Although there is experience with doses up to 30 mg/m2/wk in children, there are too few published data to assess how over 20 mg/m2/wk might affect the risk of serious toxicity in children. Experience does suggest, however, that children receiving 20 to 30 mg/m2/wk (0.65 to1.0 mg/kg/wk) may have better absorption and fewer gastrointestinal side effects if methotrexate is administered either intramuscularly or subcutaneously.

  Therapeutic response usually begins wiht in 3to 6 weeks and the patient may continue to improve for another 12 weeks or more.

  The optimal duration of therapy is unknown. Limited data available from long-term studies in adults indicate that the initial clinical improvement is maintained for at least two years with continued therapy. When methotrexate is discontinued, the srthritis usually worsens within 3 to 6 weeks.

  The patient should be fully informed of the risks involved and should be under constant supervision of the physician. (See Information for Patients under PRECAUTIONS.)

  Assessment of hematologic, hepatic, renal, and pulmonary function should be made by history, physical examination, and laboratory tests before beginning, periodically during, and before reinstituting methotrexate therapy. (See PRECAUTIONS.) Appropriate steps should be taken to avoid conception during methotrexate therapy. (See PRECAUTIONS and CONTRAINDICATIONS.)

  All schedules should be continually tailored to the individual patient. An initial test dose may be given prior to the regular dosing schedule to detect any extreme sensitivity to adverse effects. (See ADVERSE REACTIONS.) Maximal myelosuppression usually occurs in seven to ten days.

  Psoriasis: Recommended Starting Dose Schedules

  1. Weekly single oral, IM or IV dose schedule: 10 to 25 mg per week until adequate response is achieved.

  2. Divided oral dose schedule: 2.5 mg at 12-hour intervals for three doses.

  Doses in each schedule may be gradually adjusted to achieve optimal clinical response; 30 mg/wk should not ordinarily be exceeded.

  Once optimal clinical response has been achieved, each dosage schedule should be reduced to the lowest possible amount of drug and to the longest possible rest period. The use of methotrexate may permit the return to conventional topical therapy, which should be encouraged.

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• Childrens Cold And Coug...
  

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  Childrens Cold And Cough Nighttime

  

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  Apply the 0.1% triamcinolone acetonide cream to the affected area two to three times daily. Rub in gently.Occlusive Dressing Technique

  Occlusive dressings may be used for the management of psoriasis or other recalcitrant conditions. Gently rub a small amount of cream into the lesion until it disappears. Reapply the preparation leaving a thin coating on the lesion, cover with a pliable nonporous film, and seal the edges. If needed, additional moisture may be provided by covering the lesion with a dampened clean cotton cloth before the nonporous film is applied or by briefly wetting the affected area with water immediately prior to applying the medication. The frequency of changing dressings is best determined on an individual basis. It may be convenient to apply triamcinolone acetonide cream under an occlusive dressing in the evening and to remove the dressing in the morning (i.e., 12-hour occlusion). When utilizing the 12-hour occlusion regimen, additional cream should be applied, without occlusion, during the day. Reapplication is essential at each dressing change.

  If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.

  Cleanse the affected area and allow to dry Apply cream liberally as often as needed.

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