2 DOSAGE & ADMINISTRATION
2.1 Recommended Dosage
The volume of preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the drug manufacturer.
2.2 Instruction for Administration (Refer figure 1 – figure 5 for pictorial presentation)
Solution and fluid path are sterile and non-pyrogenic if the tip cap is in place, syringe is intact and there is no evidence of leakage. Use proper aseptic technique.
Inspect plastic wrapping. Do not use if plastic wrapping is damaged or not intact. (Figure 1)
Remove plastic packaging by tearing along perforation. (Figure 2)
Do not use if, solution is discolored, cloudy, hazy, or contains a precipitate, or if the syringe is damaged. (Figure 3)
With the tip cap of the syringe on, press the syringe forward to properly activate the syringe. Improper activation may difficult syringe use and/or may cause plunger rod separation. Never draw back rod because the product may become contaminated. (Figure 4)
Remove tip cap. Hold the syringe unit upright and prime to expel any air bubble if present. (Figure 5)
Syringe is now ready to use.
Use aseptic techniques for diluting or dissolving drugs, mix thoroughly and use according to the drug manufacturer’s label instructions.
Discard empty unit after use. Discard any unused portion. Do not reuse disposable syringes.
2.3 Preparation and Handling Precautions
Before use check for any possible incompatibility with sodium chloride.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. Do not administer unless solution is clear and seal is intact.
Do not store reconstituted solution or drugs for injection unless otherwise directed by the manufacturer of the solute.
Adding additives may be incompatible.
Do not use if, solution is discolored, cloudy, hazy, or contains a precipitate, or if the syringe is damaged.
Do not freeze.
Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat.