Medicure International Inc

Medicure International Inc Drugs

• Aggrastat
  

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  Aggrastat

  

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  Administer intravenously 25 mcg/kg within 5 minutes and then 0.15 mcg/kg/min (or 0.075 mcg/kg/min for patients with creatinine clearance ≤60 mL/min), for up to 18 hours. This is not the regimen that was used in studies that established effectiveness of AGGRASTAT [see Clinical Studies (14)].

  The instructions by weight and creatinine clearance (CrCl) are tabulated in Table 1.

  Table 1 Dosing by Weight and CrCl

  Weight (kg)

  Within 5 min All Patients (mL)

  Maintenance Infusion Rate(mL/hr.)

  CrCl >60 mL/min

  CrCl ≤60 mL/min

  30-37

  17

  6

  3

  38-45

  21

  7.5

  3.75

  46-54

  25

  9

  4.5

  55-62

  29

  10.5

  5.25

  63-70

  33

  12

  6

  71-79

  37.5

  13.5

  6.75

  80-87

  42

  15

  7.5

  88-95

  46

  16.5

  8.25

  96-104

  50

  18

  9

  105-112

  54

  19.5

  9.75

  113-120

  58

  21

  10.5

  121-128

  62

  22.5

  11.25

  129-137

  66.5

  24

  12

  138-145

  71

  25.5

  12.75

  146-153

  75

  27

  13.5

  Important Administration Instructions

  To open the container, first tear off its foil overpouch. The plastic may be somewhat opaque because of moisture absorption during sterilization; the opacity will diminish gradually. Check for leaks by squeezing the inner bag firmly; if any leaks are found or sterility is suspect then the solution should be discarded. Do not use unless the solution is clear and the seal is intact. Suspend the container from its eyelet support, remove the plastic protector from the outlet port, and attach a conventional administration set. You may administer AGGRASTAT in the same intravenous line as atropine sulfate, dobutamine, dopamine, epinephrine hydrochloride (HCl), famotidine injection, furosemide, lidocaine, midazolam HCl, morphine sulfate, nitroglycerin, potassium chloride, and propranolol HCl. Do not administer AGGRASTAT through the same IV line as diazepam. Do not add other drugs or remove solution directly from the bag with a syringe. Do not use plastic containers in series connections; such use can result in air embolism by drawing air from the first container if it is empty of solution. Discard any unused portion left in the bag.

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