Method Pharmaceuticals, Llc

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Method Pharmaceuticals, Llc Drugs

Thrivite Rx

Thrivite Rx

One tablet daily, or as prescribed by a physician.

Supplement Facts

Servings per Bottle: 90 Serving Size: 1 Tablet

Each Tablet %DV Adults and Children contains 4 Years or More

Folic Acid 1 mg 250%

Vitamin A (beta carotene) 4000 IU 80%

Vitamin D3 (cholecalciferol) 400 IU 100%

Vitamin E

(dl-alpha-tocopheryl acetate) 30 IU 100%

Vitamin C (ascorbic acid) 120 mg 200%

Vitamin B1 (thiamine mononitrate) 3 mg 200%

Vitamin B2 (riboflavin) 3 mg 177%

Niacin (niacinamide) 20 mg 100%

Vitamin B6 (pyridoxine HCl) 3 mg 150%

Vitamin B12 (cyanocobalamin) 8 mcg 133%

Biotin 30 mcg 10%

Pantothenic Acid (calcium pantothenate) 7 mg 70%

Calcium (calcium carbonate) 200 mg 20%

Iodine (potassium iodide) 150 mcg 100%

Zinc (zinc oxide) 15 mg 100%

Magnesium (magnesium oxide) 100 mg 25%

Iron (carbonyl iron) 29 mg 161%

Copper (cupric oxide) 3 mg 150%

ALSO CONTAINS: Microcrystalline Cellulose, Pregelatinized Starch, Hypromellose, Titanium Dioxide, Polyvinyl Alcohol, Polyethylene Glycol, Talc, Croscarmellose Sodium, Magnesium Stearate, Stearic Acid, Fumed Silica.

HOW SUPPLIED: Thrivite Rx is supplied as an oval, white tablet with "M133" debossed on one side. Thrivite Rx is dispensed in bottles of 90 tablets.
Dothelle Dha

Dothelle Dha

Adults (persons over 12 years of age), One (1) capsule daily, between meals, or as prescribed by a physician. Do not exceed recommended dosage. Do not administer to children under the age of 12.

Supplement Facts

Servings per Bottle: 30

Serving Size: 1 Capsule %DV for Pregnant

Each Capsule contains and Lactating Women

Ferrous Fumarate (anhydrous) 53.5 mg

(Equiv. to about 17.5 mg of Elemental Iron)

Polysaccharide Iron Complex 38 mg 194%¶

(Equiv. to about 17.5 mg of Elemental Iron)

Vitamin C* 25 mg 42%

Folic Acid 1 mg 125%

Vitamin B1 (thiamine mononitrate) 2 mg 118%

Vitamin B2 (riboflavin) 3 mg 150%

Vitamin B3* 1.8 mg 9%

Vitamin B5 (d-calcium pantothenate) 5 mg 50%

Vitamin B6 (pyridoxine HCl) 25 mg 1000%

Vitamin B7 (biotin) 300 mcg 100%

Vitamin B12 (cyanocobalamin) 12.5 mcg 156%

Copper (as copper sulfate) 2 mg 100%

Magnesium (as magnesium sulfate) 5 mg 1%

Zinc (as zinc sulfate) 10 mg 67%

Omega-3 Fatty acids† 200 mg ‡

DHA (docosahexaenoic acid) 156 mg ‡

EPA (eicosapentaenoic acid) 39 mg ‡

* Also containing Ascorbic Acid Precursors as (1) Acid Metabolites including niacinamide ascorbate, calcium ascorbate, magnesium ascorbate, potassium ascorbate and sodium ascorbate (2) Basic Amino Acids including lysine acetate; (3) Flavonoids including hesperidin; and (4) Glutathione.

¶ Total Iron: Ferrous Fumarate + Polysaccharide Iron Complex.

† At least 200 mg Omega-3 Fatty Acids derived from 310 mg fish oil. ‡ Daily value not established.

ALSO CONTAINS: Gelatin, Glycerin, Soy Lecithin, Yellow Beeswax, Natural Creamy Orange Flavour, L-Lysine Acetate, Hesperidin Complex, D&C Blue # 1, Sodium Citrate, Titanium Dioxide, Ethyl Vanillin, L-Glutathione, FD&C Yellow # 6.

HOW SUPPLIED: The Dothelle DHA capsule is an oval, blue soft gelatin capsule, and is imprinted with "M121". Dothelle DHA is dispensed in child-resistant bottles of 30 capsules.
Rulavite Dha

Rulavite Dha

Before, during, and/or after pregnancy, one capsule daily or as prescribed by a physician.

Each capsule has the following active ingredient:

Folate ........................................................................................... 1 mg

(L-Methylfolate-calcium, or 6(S)-5-MTHF-Ca 600 mcg) (folic acid, USP 400 mcg)

Each capsule also contains the following ingredients for nutritional supplementation:

Vitamin C (ascorbic acid) .............................................................. 85 mg

Vitamin D3 (cholecalciferol) .......................................................... 200 IU

Vitamin E (d-alpha tocopherol) ........................................................ 10 IU

Vitamin B6 (pyridoxine HCI) ......................................................... 25 mg

Vitamin B12 (cyanocobalamin) .................................................... 12 mcg

Calcium (calcium carbonate) ....................................................... 140 mg

Iron (ferrous fumarate) ................................................................ 27 mg

Magnesium (magnesium oxide) ................................................... 45 mg

Docosahexaenoic Acid (DHA) ...................................................... 300 mg*

* from at least 330 mg purified fish oil.

ALSO CONTAINS: Gelatin, Glycerin, Soybean Oil, Yellow Beeswax, Soy Lecithin, Natural Creamy Orange Flavour, FD&C Blue # 1, Sodium Citrate, Titanium Dioxide, Ethyl Vanillin, L-Glutathione, Sodium Ascorbate, FD&C Yellow # 6.

HOW SUPPLIED: Rulavite DHA are blue coated soft gelatin capsules imprinted with "M122”. Rulavite DHA is dispensed in child-resistant bottles of 30 capsules.
Thrivite 19

Thrivite 19

One or two tablets daily, in divided doses, or as directed by a physician.
Selenium Sulfide Shampo...

Selenium Sulfide Shampoo

SHAKE WELL BEFORE USING

For seborrheic dermatitis and dandruff: Wet skin and apply to areas to be cleansed. Massage gently into the skin working into a full lather. Rinse thoroughly and pat dry. Generally two applications each week for two weeks will control symptoms. Subsequently, shampoo may be used less frequently, or as directed by a physician. It should not be applied more frequently than necessary to maintain control.

For tinea versicolor: Wet skin and apply to areas to be cleansed. Massage gently into the skin working into a full lather. Allow product to remain on skin for ten minutes, then rinse thoroughly and pat dry. Repeat procedure once a day for seven days or as directed by a physician.
Focalgin Dss

Focalgin Dss

One tablet and one capsule daily or as directed by a licensed medical practitioner.

INGREDIENTS:

prenatal tablet contains the following dietary ingredients:

Iron (Carbonyl Iron, Ferrous Gluconate) ......... 90 mg

Folic Acid .................................................... 1 mg

Vitamin B12 (Cyanocobalamin) ................. 12 mcg

Vitamin C (Ascorbic Acid) .......................... 120 mg

Docusate Sodium ...................................... 50 mg

ALSO CONTAINS: Citric Acid, Croscarmellose Sodium, Fumed Silica, Green Color Coating (FD&C Blue #1 Aluminum Lake, FD&C Blue #2 Aluminum Lake, FD&C Yellow #5 Aluminum Lake, Hydroxypropylmethyl Cellulose, Polyvinyl Alcohol, Talc, Titanium Dioxide, Triacetin), Magnesium Stearate, Microcrystalline Cellulose, Pregelatinized Starch, Stearic Acid and TriPotassium Citrate.

HOW SUPPLIED:

Focalgin™ DSS (58657-112-90) is a green, rectangle shaped, film-coated tablet, debossed with "DSS" on one side and blank on the other, and packaged in bottles of 90.
Calcarea Sulphurica 30c...

Calcarea Sulphurica 30c

One tablet and one capsule daily or as directed by a licensed medical practitioner.

INGREDIENTS:

prenatal tablet contains the following dietary ingredients:

Vitamin C (Ascorbic acid) .............................................................................................................. 120 mg

Calcium (Calcium citrate) .............................................................................................................. 159 mg

Iron (Carbonyl iron, ferrous gluconate) ............................................................................................ 90 mg

Vitamin D3 (Cholecalciferol)............................................................................................................ 400 IU

Vitamin E (dl-alpha tocopheryl acetate) ............................................................................................. 30 IU

Thiamin (Vitamin B1) ........................................................................................................................ 3 mg

Riboflavin (Vitamin B2) ................................................................................................................. 3.4 mg

Niacinamide (Vitamin B3) ............................................................................................................... 20 mg

Vitamin B6 (Pyridoxine HCl) ............................................................................................................ 20 mg

Folic Acid .......................................................................................................................................... 1 mg

Iodine (Potassium iodide) ............................................................................................................ 150 mcg

Zinc (Zinc oxide) ............................................................................................................................. 25 mg

Copper (Cupric oxide) ....................................................................................................................... 2 mg

Docusate Sodium ............................................................................................................................ 50 mg

ALSO CONTAINS:(tablet): Citric Acid, Croscarmellose Sodium, Fumed Silica, Magnesium Stearate, Microcrystalline Cellulose, Pregelatinized Starch, Silicon Dioxide, Stearic Acid, TriPotassium Citrate, White Coating (Hypromellose, Polyethylene Glycol, PVA, Talc, Titanium Dioxide).

Each DHA gelatin capsule contains:

Docosahexaenoic Acid (DHA) ........................................................................................................ 300 mg

*Derived from algal oil containing less than 1% EPA.

ALSO CONTAINS:(DHA softgel): Ethyl Vanillin, Gelatin, Glycerin, Purified Water, Vitamin E.

HOW SUPPLIED:

The prenatal vitamin is a white, coated, oval multivitamin/mineral tablet. The tablet is debossed "M110" on one side. The essential fatty acid DHA capsule is oblong and clear with yellowish oil inside. Child-resistant blister packs of 30 tablets and 30 capsules. 58657-110-60.
Relador Pak With Occlus...

Relador Pak With Occlusive Dressing

One tablet and one capsule daily or as directed by a licensed medical practitioner.

INGREDIENTS:

prenatal tablet contains the following dietary ingredients:

Vitamin C (Ascorbic acid) ........................................................................................................... 120 mg

Calcium (Calcium citrate) ............................................................................................................ 124 mg

Iron (Carbonyl iron, ferrous gluconate) ....................................................................................... 35 mg

Vitamin D3 (Cholecalciferol) ......................................................................................................... 400 IU

Vitamin E (dl-alpha tocopheryl acetate) ......................................................................................... 30 IU

Thiamin (Vitamin B1) ..................................................................................................................... 3 mg

Riboflavin (Vitamin B2) .............................................................................................................. 3.4 mg

Niacinamide (Vitamin B3) ............................................................................................................ 20 mg

Vitamin B6 (Pyridoxine HCl) ......................................................................................................... 25 mg

Folic Acid ......................................................................................................................................... 1 mg

Iodine (Potassium iodide) ......................................................................................................... 150 mcg

Zinc (Zinc oxide) ......................................................................................................................... 25 mg

Copper (Cupric oxide) .................................................................................................................... 2 mg

Docusate Sodium ......................................................................................................................... 50 mg

ALSO CONTAINS:(tablet): Citric Acid, Croscarmellose Sodium, Fumed Silica, Magnesium Stearate, Microcrystalline Cellulose, Pregelatinized Starch, Silicon Dioxide, Stearic Acid, TriPotassium Citrate, White Coating (Hypromellose, Polyethylene Glycol, PVA, Talc, Titanium Dioxide).

Each DHA gelatin capsule contains:

Docosahexaenoic Acid (DHA) ..................................................................................................... 300 mg

*Derived from algal oil containing less than 1% EPA.

ALSO CONTAINS (DHA softgel): Ethyl Vanillin, Gelatin, Glycerin, Purified Water, Vitamin E.

HOW SUPPLIED:

The prenatal vitamin is a white, coated, oval multivitamin/mineral tablet. The tablet is debossed "M111" on one side. The essential fatty acid DHA capsule is oblong and clear with yellowish oil inside. Child-resistant blister packs of 30 tablets and 30 capsules. 58657-111-60.
Proair Respiclick

Proair Respiclick

The usual adult dose may be taken as one capsule twice daily (1 capsule), or two capsules once daily (2 capsules), or as directed by a licensed medical practitioner.

FOLATE is essential for the production of certain coenzymes in many metabolic systems such as purine and pyrimidine synthesis. About 70% of food folate and cellular folate is comprised of L-methylfolate. It is the primary form of folate in circulation, and is also the form transported across membranes – particularly across the blood brain barrier – into peripheral tissues. In the cell, L-methylfolate is used in the remethylation of homocysteine to form methionine and tetrahydrofolate (THF). L-methylfolate is converted into functional, metabolically active coenzyme forms for use in the body, and supplies the active folate substrate, THF for use in transformylation and methylation biochemistry.1

Folates are best known for reducing the incidence of fetal neural tube defects (NTDs).2,3,4 NTDs are congenital malformations produced by failure of the neural tube to form and close properly during embryonic development.4,5 During the first four weeks of pregnancy – when many women do not even realize that they have conceived, adequate maternal folate intake is essential to reduce the risk of NTDs. Folate is also essential in the synthesis and maintenance of nucleoprotein in erythropoiesis. It also promotes white blood cell (WBC) and platelet production in folate-deficiency anemia. Folate is associated with methylation and transformylation biochemistry. Folate is involved in transformylation and methylation metabolism as well as, indirectly, succinylation metabolism (through the “methyl trap” hypothesis). Folate plays a central role in the formation of nucleic acid precursors, such as thymidylic acid and purine nucleotides, which are essential for nucleic acid synthesis and cell division. IOM/NAS (1998) noted that the evidence for a protective effect from folate supplements is much stronger than that for food folate.4 Other ingredients are added to folate as cofactors, coenzymes and co-metabolites; in studies by Czeizel and Dudas (1992) and Berry et al. (1999), factors other than folate intake may affect the magnitude of risk reduction or participate in a co-protective effect with folate.4,5

L-methylfolate supplementation increases the formation of endothelial nitric oxide synthase resulting in increase nitric oxide. This causes vasodilation to the nerves, increasing blood supply to the nerves, and reducing vascular oxidative stress.6 L-methylfolate supplementation also increases nitric oxide levels by increasing the amount of tetrahydrobioterin (BH4). BH4 is required for nitric oxide synthesis.7

FOLATE COENZYMES, COFACTORS, AND COMETABOLITES - The following ingredients are added to enhance the bioavailable potential of folate, and include:

METHYLCOBALAMIN - Methylcobalamin is required for two important reactions: the conversion of methylmalonyl CoA to succinyl CoA, a Krebs cycle intermediate, and the conversion of homocysteine to methionine, a reaction in which the methyl group of L-methylfolate is donated to remethylate homocysteine. Homocysteine has been found to stimulate or alter transcription factors involved in inflammation, with an important ancillary consequence of BH4 depletion. For example, it has been reported that homocysteine-mediated activation of sterol regulatory element binding protein (SREBP) upregulates expression of 3-hydroxy-3-methyl-glutaryl-coenzyme (HMG-CoA reductase) with increased biosynthesis and cellular uptake of cholesterol, the depletion of BH4 being a secondary effect.

PYRIDOXAL-5’-PHOSPHATE (PLP) is the active form of vitamin B6. The aromatic amino acid decarboxylase considered to decarboxylate both dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) requires pyridoxal-5'-phosphate as coenzyme.

FOLATE REGULATION: The Federal Register Notices from 1971 to 1973 establish that increased folate is proper supplement in megaloblastic anemias of tropical and nontropical sprue, nutritional origin, pregnancy, infancy, and childhood.8,9 Folate metabolism may be affected by malabsorption issues that differ widely among population groups. The March 5, 1996 Federal Register Notice (61 FR 8760) states “The agency concluded that the scientific literature did not support the superiority of any one source of folate over others, and that the data were insufficient to provide a basis for stating that a specific amount of folate is more effective than another amount [emphasis added].1 The actual amount and source of folate require the supervision of a licensed medical practitioner to achieve a satisfactory maintenance level, and may exceed the 0.8 mg UL. The Federal Register Notice of August 2, 1973 (38 FR 20750) specifically states that “dietary supplement preparations are available without a prescription (21 CFR 121.1134). Levels higher than dietary supplement amounts are available only with a prescription. Oral preparations supplying more than 0.8 mg of folate per dosage unit would be restricted to prescription dispensing and that a dietary supplement furnishing 0.8 mg could be prescribed when a maintenance level of 0.8 mg per day was indicated.9” When clinical symptoms have subsided and the blood picture and/or CSF folate levels have become normal, a maintenance level should be used. “Patients should be kept under supervision of a licensed practitioner and adjustment of the maintenance level made if relapse appears imminent. In the presence of alcoholism, hemolytic anemia, anticonvulsant therapy, or chronic infection, the maintenance level may need to be increased [emphasis added].9” In the Letter Regarding Dietary Supplement Health Claim for Folic Acid, Vitamin B6, and Vitamin B12 and Vascular Disease (Docket No. 99P-3029) dated November 28, 2000, FDA wrote “... high intakes of folate may partially and temporarily correct pernicious anemia while the neurological damage of vitamin B12 deficiency progresses. IOM/NAS (1998) set the UL for all adults of 1 mg per day because of devastating and irreversible neurological consequences of vitamin B12 deficiency, the data suggesting that pernicious anemia may develop at a younger age in some racial or ethnic groups, and the uncertainty about the extent of the occurrence of vitamin B12 deficiency in younger age groups (IOM/NAS, 1998) [emphasis added].10”

Summary: This product is a dietary management / prescription folate that, due to advanced folate levels, requires administration under the care of a licensed medical practitioner. The "Rx" on the label is to ensure prescription dispensing and that the product is administered under the supervision of a licensed medical practitioner due to the increased risk associated with masking of B12 deficiency (pernicious anemia). The "Rx" status and a National Drug Code (NDC), or similar Product Code, facilitate pedigree reporting requirements and supply-chain control as well as, in some cases, insurance-reimbursement applications.

These statements have not been evaluate by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.
Levomefolate Calcium An...

Levomefolate Calcium And Algal

The usual adult dose is one or two capsule(s) daily with or without food or as directed by a licensed medical practitioner.

FOLATE is essential for the production of certain coenzymes in many metabolic systems such as purine and pyrimidine synthesis. About 70% of food folate and cellular folate is comprised of L-methylfolate. It is the primary form of folate in circulation, and is also the form transported across membranes – particularly across the blood brain barrier – into peripheral tissues. In the cell, L-methylfolate is used in the remethylation of homocysteine to form methionine and tetrahydrofolate (THF). L-methylfolate is converted into functional, metabolically active coenzyme forms for use in the body, and supplies the active folate substrate, THF for use in transformylation and methylation biochemistry.1

Folates are known for reducing the incidence of fetal neural tube defects (NTDs).2,3,4 NTDs are congenital malformations produced by failure of the neural tube to form and close properly during embryonic development.4,5 During the first four weeks of pregnancy, when many women do not even realize that they have conceived, adequate maternal folate intake is reported to reduce the risk of NTDs. Folate is also essential in the synthesis and maintenance of nucleoprotein in erythropoiesis. It also promotes white blood cell (WBC) and platelet production in folate-deficiency anemia. Folate is associated with methylation and transformylation biochemistry. Folate is involved in transformylation and methylation metabolism as well as, indirectly, succinylation metabolism (through the “methyl trap” hypothesis). Folate plays a central role in the formation of nucleic acid precursors, such as thymidylic acid and purine nucleotides, which are essential for nucleic acid synthesis and cell division. IOM/NAS (1998) noted that the evidence for a protective effect from folate supplements is much stronger than that for food folate.4 Other ingredients are added to folate as cofactors, coenzymes and co-metabolites; in studies by Czeizel and Dudas (1992) and Berry et al. (1999), factors other than folate intake may affect the magnitude of risk reduction or participate in a co-protective effect with folate.4,5

It is reported that L-methylfolate supplementation increases BH4 synthesis through a pterin “salvage pathway”, which converts sepiapterin/dihydrobiopterin (BH2) to BH4 through the enzymatic activity of dihydrofolate reductase (DHFR). Additionally, it is reported that L-methylfolate (L-MTHF) may enhance or even “stand in” for BH4. BH4 can also be regenerated from quinonoid dihydrobiopterin by dihydropteridine reductase (DHPR) and synthesized de novo by conversion from guanosine triphosphate (GTP). BH4 functions as a cofactor for the enzymes responsible for the production of monoamine neurotransmitters (serotonin, epinephrine, dopamine). BH4 is the cofactor for conversion of phenylalanine to tyrosine. Tyrosine is then converted into DOPA, and eventually to norepinephrine and epinephrine. The conversion of tryptophan to serotonin also requires BH4.

FOLATE REGULATION: The Federal Register Notices from 1971 to 1973 establish that increased folate is a proper supplement in megaloblastic anemias of tropical and nontropical sprue, nutritional origin, pregnancy, infancy and childhood.6,7 Folate metabolism may be affected by malabsorption issues that differ widely among population groups. The March 5, 1996 Federal Register Notice (61 FR 8760) states “The agency concluded that the scientific literature did not support the superiority of any one source of folate over others, and that the data were insufficient to provide a basis for stating that a specific amount of folate is more effective than another amount" [emphasis added].1 The Federal Register Notice of August 2, 1973 (38 FR 20750) specifically states that “dietary supplement preparations are available without a prescription (21 CFR 121.1134). Levels higher than dietary supplement amounts are available only with a prescription. Oral preparations supplying more than 0.8 mg of folate per dosage unit would be restricted to prescription dispensing and that a dietary supplement furnishing 0.8 mg could be prescribed when a maintenance level of 0.8 mg per day was indicated.7”

"Patients should be kept under supervision of a licensed practitioner and adjustment of the maintenance level made if relapse appears imminent. In the presence of alcoholism, hemolytic anemia, anticonvulsant therapy, or chronic infection, the maintenance level may need to be increased [emphasis added].7” In the Letter Regarding Dietary Supplement Health Claim for Folic Acid, Vitamin B6, and Vitamin B12 and Vascular Disease (Docket No. 99P-3029) dated November 28, 2000, FDA wrote “... high intakes of folate may partially and temporarily correct pernicious anemia while the neurological damage of vitamin B12 deficiency progresses. IOM/NAS (1998) set the UL for all adults of 1 mg per day because of devastating and irreversible neurological consequences of vitamin B12 deficiency, the data suggesting that pernicious anemia may develop at a younger age in some racial or ethnic groups, and the uncertainty about the extent of the occurrence of vitamin B12 deficiency in younger age groups (IOM/NAS, 1998) [emphasis added].8”

Summary: This product is a dietary management / prescription folate that, due to advanced folate levels, requires administration under the care of a licensed medical practitioner. The "Rx" on the label is to ensure prescription dispensing and that the product is administered under the supervision of a licensed medical practitioner due to the increased risk associated with masking of B12 deficiency (pernicious anemia). The "Rx" status and a National Drug Code (NDC), or similar Product Code, facilitate pedigree reporting requirements and supply-chain control as well as, in some cases, insurance-reimbursement applications.

These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.
Sodium Sulfacetamide An...

Sodium Sulfacetamide And Sulfur 10 Percent And 2 Percent Cleanser

Wash affected areas once or twice daily, or as directed by your physician. Avoid contact with eyes or mucous membranes. Wet skin and liberally apply to areas to be cleansed. Massage gently into skin for 10 to 20 seconds, working into a full lather, rinse thoroughly and pat dry. If skin dryness occurs, it may be controlled by rinsing product off sooner or using less frequently.
Sodium Sulfacetamide An...

Sodium Sulfacetamide And Sulfur 10 Percent And 5 Percent Cleanser

Wash affected areas once or twice daily, or as directed by your physician. Avoid contact with eyes or mucous membranes. Wet skin and liberally apply to areas to be cleansed. Massage gently into skin for 10 to 20 seconds, working into a full lather, rinse thoroughly and pat dry. If skin dryness occurs, it may be controlled by rinsing product off sooner or using less frequently.
Hyoscyamine Sulfate Sol...

Hyoscyamine Sulfate Solution

Dosage may be adjusted according to the conditions and severity of symptoms. Measure dosage very carefully.

Adults and pediatric patients 12 years of age and older: 1 to 2 mL every four hours or as needed. Do not exceed 12 mL in 24 hours.

Pediatric patients 2 to under 12 years of age: 1/4 to 1 mL every four hours or as needed. Do not exceed 6 mL in 24 hours.

Pediatric patients under 2 years of age: The following dosage guide is based upon body weight. The doses may be repeated every four hours or as needed.
Do NotExceed Body Weight Usual Dose In 24 Hours 3.4 kg (7.5 lb) 4 drops 24 drops 5 kg (11 lb) 5 drops 30 drops 7 kg (15 lb) 6 drops 36 drops 10 kg (22 lb) 8 drops 48 drops
Package of Hyoscyamine Sulfate Oral Drops is accompanied with a dropper having markings of 3, 4, 5 DROPS, and 0.25 mL. The approximate equivalent amount of hyoscyamine sulfate drops (mL) and its equivalent amount of hyoscyamine sulfate (mg) for each marking are as follows:
Uro-l

Uro-l

Adults: One tablet orally 4 times per day followed by liberal fluid intake.

Pediatric: Dosage must be individualized by physician for older children. Not recommended for use in children six years of age or younger.
Antipyrine And Benzocai...

Antipyrine And Benzocaine Otic

Acute otitis media: Instill Antipyrine and Benzocaine Otic Solution, permitting the solution to run along the wall of the ear canal until it is filled. Avoid touching the ear with dropper. Then moisten a cotton pledget with Antipyrine and Benzocaine Otic Solution and insert into meatus. Repeat every one to two hours until pain and congestion are relieved.

Removal of Cerumen:Before: Instill Antipyrine and Benzocaine Otic Solution three times daily for two or three days to help detach cerumen from wall of ear canal and facilitate removal.

After: Antipyrine and Benzocaine Otic Solution is useful for drying out the ear canal or relieving discomfort.

Before and after removal of cerumen, a cotton pledget moistened with Antipyrine and Benzocaine Otic Solution should be inserted into the meatus following instillation.
Uro-mp

Uro-mp

Adults: One tablet orally 4 times per day followed by liberal fluid intake.

Pediatric: Dosage must be individualized by physician for older children. Not recommended for use in children six years of age or younger.
Glipizide

Glipizide

One or two tablets daily, in divided doses, or as directed by a physician.
Potassium Citrate-citri...

Potassium Citrate-citric Acid

Potassium Citrate-Citric Acid Solution should be taken diluted in water according to directions, followed by additional water, if desired. Palatability is enhanced if chilled before taking.

Proper dilution may help prevent gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations.

Usual Adult Dose: 3 to 6 teaspoonfuls (15 to 30 mL), diluted with 1 glass of water, after meals and at bedtime, or as directed by a physician.

Usual Pediatric Dose: 1 to 3 teaspoonfuls (5 to 15 mL), diluted with 1/2 glass of water, after meals and at bedtime, or as directed by a physician.

Usual Dosage Range: 2 to 3 teaspoonfuls (10 to 15 mL), diluted with a glassful of water, taken four times a day. Potassium Citrate-Citric Acid Solution, diluted with a glassful of water, taken four times a day will usually maintain a urinary pH of 7.0-7.6 throughout most of the 24 hours without unpleasant side effects. To check urinary pH, HYDRION Paper (pH 6.0-8.0) or NITRAZINE Paper (pH 4.5-7.5) are available and easy to use.
Phenazopyridine Hcl 200...

Phenazopyridine Hcl 200mg

Adults: 200 mg 3 times daily after meals. When used concomitantly with an antibacterial agent for the treatment of a urinary tract infection, the administration of phenazopyridine should not exceed 2 days. If symptoms persist, the patient should be re-evaluated.
Sodium Citrate-citric A...

Sodium Citrate-citric Acid

Sodium Citrate-Citric Acid Solution should be administered by diluting in water, followed by additional water, if desired. SHAKE WELL BEFORE USING.

For Systemic Alkalization:

Usual Adult Dosage: 2 to 6 teaspoonfuls (10 to 30 mL), diluted in 1 to 3 ounces of water, after meals and at bedtime, or as directed by a physician.

Usual Pediatric Dose: 1 to 3 teaspoonfuls (5 to 15 mL), diluted in 1 to 3 ounces of water, after meals and at bedtime, or as directed by a physician. For children under two years of age, use is based on consultation with a physician.

As a neutralizing buffer: 3 teaspoonfuls (15 mL), diluted with 15 mL water, taken as a single dose, or as directed by a physician.
Paroxetine

Paroxetine

Dosage may be adjusted according to the conditions and severity of symptoms. Measure dosage very carefully.

Adults and pediatric patients 12 years of age and older: 1 to 2 teaspoonfuls every four hours or as needed. Do not exceed 12 teaspoonfuls in 24 hours.

Pediatric patients 2 to under 12 years of age: Please see the following dosage guide based on body weight. The doses may be repeated every four hours or as needed. Do not exceed 6 teaspoonfuls in 24 hours.

Body Weight       Usual Dose

10 kg (22 lb)       1/4 teaspoonful (1.25 mL)

20 kg (44 lb)       1/2 teaspoonful (2.5 mL)

40 kg (88 lb)       3/4 teaspoonful (3.75 mL)

50 kg (110 lb)       1 teaspoonful (5 mL)
Vesicare

Vesicare

The usual adult dose may be taken as one caplet daily, or as directed by a licensed medical practitioner.

FOLATE is essential for the production of certain coenzymes in many metabolic systems such as purine and pyrimidine synthesis. About 70% of food folate and cellular folate is comprised of L-methylfolate. It is the primary form of folate in circulation, and is also the form transported across membranes – particularly across the blood brain barrier – into peripheral tissues. In the cell, L-methylfolate is used in the remethylation of homocysteine to form methionine and tetrahydrofolate (THF). L-methylfolate is converted into functional, metabolically active coenzyme forms for use in the body, and supplies the active folate substrate, THF for use in transformylation and methylation biochemistry.1

Folates are best known for reducing the incidence of fetal neural tube defects (NTDs).2,3,4 NTDs are congenital malformations produced by failure of the neural tube to form and close properly during embryonic development.4,5 During the first four weeks of pregnancy – when many women do not even realize that they have conceived, adequate maternal folate intake is essential to reduce the risk of NTDs. Folate is also essential in the synthesis and maintenance of nucleoprotein in erythropoiesis. It also promotes white blood cell (WBC) and platelet production in folate-deficiency anemia. Folate is associated with methylation and transformylation biochemistry. Folate is involved in transformylation and methylation metabolism as well as, indirectly, succinylation metabolism (through the “methyl trap” hypothesis). Folate plays a central role in the formation of nucleic acid precursors, such as thymidylic acid and purine nucleotides, which are essential for nucleic acid synthesis and cell division. IOM/NAS (1998) noted that the evidence for a protective effect from folate supplements is much stronger than that for food folate.4 Other ingredients are added to folate as cofactors, coenzymes and co-metabolites; in studies by Czeizel and Dudas (1992) and Berry et al. (1999), factors other than folate intake may affect the magnitude of risk reduction or participate in a co-protective effect with folate.4,5

L-methylfolate supplementation increases the formation of endothelial nitric oxide synthase resulting in increase nitric oxide. This causes vasodilation to the nerves, increasing blood supply to the nerves, and reducing vascular oxidative stress.6 L-methylfolate supplementation also increases nitric oxide levels by increasing the amount of tetrahydrobiopterin (BH4). BH4 is required for nitric oxide synthesis.7

FOLATE COENZYMES, COFACTORS, AND COMETABOLITES - The following ingredients are added to enhance the bioavailable potential of folate, and include:

METHYLCOBALAMIN - Methylcobalamin is required for two important reactions: the conversion of methylmalonyl CoA to succinyl CoA, a Krebs cycle intermediate, and the conversion of homocysteine to methionine, a reaction in which the methyl group of L-methylfolate is donated to remethylate homocysteine. Homocysteine has been found to stimulate or alter transcription factors involved in inflammation, with an important ancillary consequence of BH4 depletion. For example, it has been reported that homocysteine-mediated activation of sterol regulatory element binding protein (SREBP) upregulates expression of 3-hydroxy-3-methyl-glutaryl-coenzyme (HMG-CoA reductase) with increased biosynthesis and cellular uptake of cholesterol, the depletion of BH4 being a secondary effect.

FOLATE REGULATION: The Federal Register Notices from 1971 to 1973 establish that increased folate is proper supplement in megaloblastic anemias of tropical and nontropical sprue, nutritional origin, pregnancy, infancy, and childhood.8,9 Folate metabolism may be affected by malabsorption issues that differ widely among population groups. The March 5, 1996 Federal Register Notice (61 FR 8760) states “The agency concluded that the scientific literature did not support the superiority of any one source of folate over others, and that the data were insufficient to provide a basis for stating that a specific amount of folate is more effective than another amount [emphasis added].1 The actual amount and source of folate require the supervision of a licensed medical practitioner to achieve a satisfactory maintenance level, and may exceed the 0.8 mg UL. The Federal Register Notice of August 2, 1973 (38 FR 20750) specifically states that “dietary supplement preparations are available without a prescription (21 CFR 121.1134). Levels higher than dietary supplement amounts are available only with a prescription. Oral preparations supplying more than 0.8 mg of folate per dosage unit would be restricted to prescription dispensing and that a dietary supplement furnishing 0.8 mg could be prescribed when a maintenance level of 0.8 mg per day was indicated.9” When clinical symptoms have subsided and the blood picture and/or CSF folate levels have become normal, a maintenance level should be used. "Patients should be kept under supervision of a licensed practitioner and adjustment of the maintenance level made if relapse appears imminent. In the presence of alcoholism, hemolytic anemia, anticonvulsant therapy, or chronic infection, the maintenance level may need to be increased [emphasis added].9” In the Letter Regarding Dietary Supplement Health Claim for Folic Acid, Vitamin B6, and Vitamin B12 and Vascular Disease (Docket No. 99P-3029) dated November 28, 2000, FDA wrote “... high intakes of folate may partially and temporarily correct pernicious anemia while the neurological damage of vitamin B12 deficiency progresses. IOM/NAS (1998) set the UL for all adults of 1 mg per day because of devastating and irreversible neurological consequences of vitamin B12 deficiency, the data suggesting that pernicious anemia may develop at a younger age in some racial or ethnic groups, and the uncertainty about the extent of the occurrence of vitamin B12 deficiency in younger age groups (IOM/NAS, 1998) [emphasis added].10”

Summary: This product is a dietary management / prescription folate that, due to advanced folate levels, requires administration under the care of a licensed medical practitioner. The "Rx" on the label is to ensure prescription dispensing and that the product is administered under the supervision of a licensed medical practitioner due to the increased risk associated with masking of B12 deficiency (pernicious anemia). The "Rx" status and a National Drug Code (NDC), or similar Product Code, facilitate pedigree reporting requirements and supply-chain control as well as, in some cases, insurance-reimbursement applications.

These statements have not been evaluate by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.
Neutrogena Rapid Clear ...

Neutrogena Rapid Clear Acne Eliminating Spot

Do not exceed recommended dosage.

Overdose Warnings:

Taking more than the recommended dose (overdose) can cause serious health problems, including liver damage.
adults and children 12 years of age and older: take 2 teaspoonfuls (10 mL) every 6 hours; do not exceed 8 teaspoonfuls (40 mL) in 24 hours not recommended for children under the age of 12: this adult strength product will provide more than the recommended dose (overdose), and may cause liver damage
Equaline Antacid Regula...

Equaline Antacid Regular Strength

Do not exceed the recommended dosage because severe liver damage may occur.

Tell your doctor about all usage of pain relievers.

FOR RELIEF OF MIGRAINE HEADACHE: The usual adult dosage is two capsules at once, followed by one capsule every hour until relieved, up to 5 capsules within a twelve hour period.

FOR RELIEF OF TENSION HEADACHE: The usual adult dosage is one or two capsules every four hours up to 8 capsules a day.
Prefol-dha

Prefol-dha

Before, during, and or after pregnancy, one tablet daily or as prescribed by a physician.
Focalgin B

Focalgin B

Adults: 200 mg 3 times daily after meals. When used concomitantly with an antibacterial agent for the treatment of a urinary tract infection, the administration of phenazopyridine should not exceed 2 days. If symptoms persist, the patient should be re-evaluated.
Female Support

Female Support

Oral administration is preferred. Although most patients with malabsorption cannot absorb food folates, they are able to absorb folic acid given orally. Parenteral administration is not advocated but may be necessary in some individuals (e.g., patients receiving parenteral or enteral alimentation). Doses greater than 0.1 mg should not be used unless anemia due to vitamin B12 deficiency has been ruled out or is being adequately treated with a cobalamin. Daily doses greater than 1 mg do not enhance the hematologic effect, and most of the excess is excreted unchanged in the urine. The usual therapeutic dosage in adults and children (regardless of age) is up to 1 mg daily. Resistant cases may require larger doses. When clinical symptoms have subsided and the blood picture has become normal, a daily maintenance level should be used, i.e., 0.1 mg for infants and up to 0.3 mg for children under 4 years of age, 0.4 mg for adults and children 4 or more years of age, and 0.8 mg for pregnant and lactating women, but never less than 0.1 mg/day. Patients should be kept under close supervision and adjustment of the maintenance level made if relapse appears imminent.

In the presence of alcoholism, hemolytic anemia, anticonvulsant therapy, or chronic infection, the maintenance level may need to be increased.
Me-pb-hyos

Me-pb-hyos

The dosage of Me-PB-Hyos Elixir should be adjusted to the needs of the individual patient to assure symptomatic control with a minimum of adverse effects.

Adults: One or two teaspoonfuls of elixir three or four times a day according to conditions and severity of symptoms.

Pediatric patients: may be dosed every 4 to 6 hours.
Starting Dosage Body weight q4h q6h 10 lb. (4.5 kg) 0.5 mL 0.75 mL 20 lb. (9.1 kg) 1.0 mL 1.5 mL 30 lb. (13.6 kg) 1.5 mL 2.0 mL 50 lb. (22.7 kg) 1/2 tsp 3/4 tsp 75 lb. (34 kg) 3/4 tsp 1 tsp 100 lb. (45.4 kg) 1 tsp 1 1/2 tsp
Codeine-guaifenesin

Codeine-guaifenesin

do not exceed 6 doses in 24 hours. Adults and children 12 years of age and over: 2 tsp (10 mL) every 4 hours, or as directed by a doctor. Children 6 to under 12 years of age: 1 tsp (5 mL) every 4 hours, or as directed by a doctor. Children under 6 years of age: Consult a doctor.
Kroger Daytime Flu Plus...

Kroger Daytime Flu Plus Severe Cold And Cough

The usual adult dose is one capsule daily with or without food or as directed by a licensed medical practitioner.

FOLATE is essential for the production of certain coenzymes in many metabolic systems such as purine and pyrimidine synthesis. About 70% of food folate and cellular folate is comprised of L-methylfolate. It is the primary form of folate in circulation, and is also the form transported across membranes – particularly across the blood brain barrier – into peripheral tissues. In the cell, L-methylfolate is used in the remethylation of homocysteine to form methionine and tetrahydrofolate (THF). L-methylfolate is converted into functional, metabolically active coenzyme forms for use in the body, and supplies the active folate substrate, THF for use in transformylation and methylation biochemistry.1

Folates are best known for reducing the incidence of fetal neural tube defects (NTDs).2,3,4 NTDs are congenital malformations produced by failure of the neural tube to form and close properly during embryonic development.4,5 During the first four weeks of pregnancy – when many women do not even realize that they have conceived, adequate maternal folate intake is essential to reduce the risk of NTDs. Folate is also essential in the synthesis and maintenance of nucleoprotein in erythropoiesis. It also promotes white blood cell (WBC) and platelet production in folate-deficiency anemia. Folate is associated with methylation and transformylation biochemistry. Folate is involved in transformylation and methylation metabolism as well as, indirectly, succinylation metabolism (through the “methyl trap” hypothesis). Folate plays a central role in the formation of nucleic acid precursors, such as thymidylic acid and purine nucleotides, which are essential for nucleic acid synthesis and cell division. IOM/NAS (1998) noted that the evidence for a protective effect from folate supplements is much stronger than that for food folate.4 Other ingredients are added to folate as cofactors, coenzymes and co-metabolites; in studies by Czeizel and Dudas (1992) and Berry et al. (1999), factors other than folate intake may affect the magnitude of risk reduction or participate in a co-protective effect with folate.4,5

Folate supplementation increases BH4 synthesis through a pterin “salvage pathway”, which converts sepiapterin/dihydrobiopterin (BH2) to BH4 through the enzymatic activity of dihydrofolate reductase (DHFR). Additionally, L-methylfolate may enhance or even “stand in” for BH4. BH4 can also be regenerated from quinonoid dihydrobiopterin by dihydropteridine reductase (DHPR) and synthesized de novo by conversion from guanosine triphosphate (GTP). BH4 functions as a cofactor for the enzymes responsible for the production of monoamine neurotransmitters (serotonin, epinephrine, dopamine). BH4 is the cofactor for conversion of phenylalanine to tyrosine. Tyrosine is then converted into DOPA, and eventually to norepinephrine and epinephrine. The conversion of tryptophan to serotonin also requires BH4.

FOLATE REGULATION: The Federal Register Notices from 1971 to 1973 establish that increased folate is proper supplement in megaloblastic anemias of tropical and nontropical sprue, nutritional origin, pregnancy, infancy and childhood.6,7 Folate metabolism may be affected by malabsorption issues that differ widely among population groups. The March 5, 1996 Federal Register Notice (61 FR 8760) states “The agency concluded that the scientific literature did not support the superiority of any one source of folate over others, and that the data were insufficient to provide a basis for stating that a specific amount of folate is more effective than another amount [emphasis added].1 The actual amount and source of folate require the supervision of a licensed medical practitioner to achieve a satisfactory maintenance level, and may exceed the 0.8 mg UL. The Federal Register Notice of August 2, 1973 (38 FR 20750) specifically states that “dietary supplement preparations are available without a prescription (21 CFR 121.1134). Levels higher than dietary supplement amounts are available only with a prescription. Oral preparations supplying more than 0.8 mg of folate per dosage unit would be restricted to prescription dispensing and that a dietary supplement furnishing 0.8 mg could be prescribed when a maintenance level of 0.8 mg per day was indicated.7” When clinical symptoms have subsided and the blood picture and/or CSF folate levels have become normal, a maintenance level should be used. "Patients should be kept under supervision of a licensed practitioner and adjustment of the maintenance level made if relapse appears imminent. In the presence of alcoholism, hemolytic anemia, anticonvulsant therapy, or chronic infection, the maintenance level may need to be increased [emphasis added].9” In the Letter Regarding Dietary Supplement Health Claim for Folic Acid, Vitamin B6, and Vitamin B12 and Vascular Disease (Docket No. 99P-3029) dated November 28, 2000, FDA wrote “... high intakes of folate may partially and temporarily correct pernicious anemia while the neurological damage of vitamin B12 deficiency progresses. IOM/NAS (1998) set the UL for all adults of 1 mg per day because of devastating and irreversible neurological consequences of vitamin B12 deficiency, the data suggesting that pernicious anemia may develop at a younger age in some racial or ethnic groups, and the uncertainty about the extent of the occurrence of vitamin B12 deficiency in younger age groups (IOM/NAS, 1998) [emphasis added].8”

Summary: This product is a dietary management / prescription folate that, due to advanced folate levels, requires administration under the care of a licensed medical practitioner. The "Rx" on the label is to ensure prescription dispensing and that the product is administered under the supervision of a licensed medical practitioner due to the increased risk associated with masking of B12 deficiency (pernicious anemia). The "Rx" status and a National Drug Code (NDC), or similar Product Code, facilitate pedigree reporting requirements and supply-chain control as well as, in some cases, insurance-reimbursement applications.

These statements have not been evaluate by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

The usual adult dose is one capsule daily, or as directed by a licensed medical practitioner.

Method Pharmaceuticals, Llc

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