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DOSAGE AND ADMINISTRATION Active Duodenal Ulcer
The recommended oral dosage for adults is 300 mg once daily at bedtime. An alternative dosage regimen is 150 mg twice daily.Maintenance of Healed Duodenal Ulcer
The recommended oral dosage for adults is 150 mg once daily at bedtime.Gastroesophageal Reflux Disease
The recommended oral dosage in adults for the treatment of erosions, ulcerations, and associated heartburn is 150 mg twice daily.Active Benign Gastric Ulcer
The recommended oral dosage is 300 mg given either as 150 mg twice daily or 300 mg once daily at bedtime. Prior to treatment, care should be taken to exclude the possibility of malignant gastric ulceration.Dosage Adjustment for Patients With Moderate to Severe Renal Insufficiency
The dose for patients with renal dysfunction should be reduced as follows:
Some elderly patients may have creatinine clearances of less than 50 mL/min, and, based on pharmacokinetic data in patients with renal impairment, the dose for such patients should be reduced accordingly. The clinical effects of this dosage reduction in patients with renal failure have not been evaluated.
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