Enroflox 100 provides flexible dosages and durations of therapy. Enroflox 100 may be administered as a single dose for one day for treatment and control of BRD (cattle) and SRD (swine), or for multiple days for BRD treatment (cattle). Selection of the appropriate dose and duration of therapy for BRD treatment in cattle should be based on an assessment of the severity of the disease, pathogen susceptibility and clinical response.
Cattle:
Single-Dose Therapy (BRD Treatment): Administer, by subcutaneous injection, a single dose of 7.5-12.5 mg/kg of body weight (3.4-5.7 mL/100 lb).
Multiple-Day Therapy (BRD Treatment): Administer daily, a subcutaneous dose of 2.5-5 mg/kg of body weight (1.1-2.3 mL/100 lb). Treatment should be repeated at 24-hour intervals for three days. Additional treatments may be given on Days 4 and 5 to animals that have shown clinical improvement but not total recovery.
Single-Dose Therapy (BRD Control): Administer, by subcutaneous injection, a single dose of 7.5 mg/kg of body weight (3.4 mL/100 lb).
Examples of conditions that may contribute to calves being at high risk for developing BRD include, but are not limited to, the following:
Transportation with animals from two or more farm origins.
An extended transport time with few to no rest stops.
An environmental temperature change of ≥30°F during transportation.
A ≥30°F range in temperature fluctuation within a 24-hour period.
Exposure to wet or cold weather conditions.
Excessive shrink (more than would be expected with a normal load of cattle).
Stressful arrival processing procedures (e.g. castration or dehorning).
Exposure within the prior 72 hours to animals showing clinical signs of BRD.
Administered dose volume should not exceed 20 mL per injection site.
Table 1 – Enroflox 100 Dose and Treatment Schedule for Cattle*
Treatment
Control
WEIGHT (lb)
Single-Dose Therapy 7.5 - 12.5 mg/kg Dose Volume (mL)
Multiple-Day Therapy 2.5 - 5.0 mg/kg Dose Volume (mL)
Single-Dose Therapy 7.5 mg/kg Dose Volume (mL)
100
3.5 - 5.5
1.5 - 2.0
3.5
200
7.0 - 11.0
2.5 - 4.5
7.0
300
10.5 - 17.0
3.5 - 6.5
10.5
400
14.0 - 22.5
4.5 - 9.0
14.0
500
17.0 - 28.5
5.5 - 11.5
17.0
600
20.5 - 34.0
7.0 - 13.5
20.5
700
24.0 - 39.5
8.0 - 16.0
24.0
800
27.5 - 45.5
9.0 - 18.0
27.5
900
31.0 - 51.0
10.0 - 20.5
31.0
1000
34.0 - 57.0
11.0 - 23.0
34.0
1100
37.5 - 62.5
12.5 - 25.0
37.5
Swine:
Administer, by subcutaneous (behind the ear) injection, a single dose of 7.5 mg/kg of body weight (3.4 mL/100 lb).
Administered dose volume should not exceed 5 mL per injection site.
Table 2 – Enroflox 100 Dose and Treatment Schedule for Swine
WEIGHT (lb)
Dose Volume (mL)
50
1.7
100
3.4
150
5.1
200
6.8
250
8.5