The recommended starting dose is one to two drops of levobunolol HCl ophthalmic solution 0.5% in the affected eye(s) once a day. Typical dosing with levobunolol HCl 0.25% is one to two drops twice daily. In patients with more severe or uncontrolled glaucoma, levobunolol HCl 0.5% can be administered b.i.d. As with any new medication, careful monitoring of patients is advised.
Dosages above one drop of levobunolol HCl 0.5% b.i.d. are not generally more effective. If the patient's IOP is not at a satisfactory level on this regimen, concomitant therapy with dipivefrin and/or epinephrine, and/or pilocarpine and other miotics, and/or systemically administered carbonic anhydrase inhibitors, such as acetazolamide, can be instituted. Patients should not typically use two or more topical ophthalmic beta-adrenergic blocking agents simultaneously.