Pfizer Animal Health
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Pfizer Animal Health Drugs
ANTISEDAN is administered intramuscularly regardless of the route used for DEXDOMITOR or DOMITOR. The atipamezole dose for the reversal of IV DEXDOMITOR or DOMITOR is 3750 mcg/m2. The atipamezole dose for the reversal of IM DEXDOMITOR or DOMITOR is 5000 mcg/m2. The concentration of ANTISEDAN is formulated so that the volume of injection is the same (mL for mL) as the recommended dose of DEXDOMITOR or DOMITOR.
The dosage of ANTISEDAN is calculated based on body surface area. Use the following tables to determine the correct injection volume or the correct ANTISEDAN dosage on the basis of kilograms of body weight.
Note that the mcg/kg dosage decreases as body weight increases.Table 1: Atipamezole dosing for reversal of IV dexmedetomidine- or medetomidine-induced sedation/analgesia: Dose table for ANTISEDAN (3750 mcg/m2) when dexmedetomidine or medetomidine is given IV For # lbs For # kg dose = mcg/kg volume = mL ANTISEDAN 4-7 2-3 300 0.1 7-9 3-4 250 0.15 9-11 4-5 230 0.2 11-22 5-10 200 0.3 22-33 10-15 170 0.4 33-44 15-20 150 0.5 44-55 20-25 140 0.6 55-66 25-30 130 0.7 66-81 30-37 120 0.8 81-99 37-45 110 0.9 99-110 45-50 105 1.0 110-132 50-60 100 1.1 132-143 60-65 95 1.2 143-165 65-75 93 1.3 165-176 75-80 91 1.4 >176 >80 90 1.5 Table 2: Atipamezole dosing for reversal of IM dexmedetomidine- or medetomidine-induced sedation/analgesia: Dose table for ANTISEDAN (5000 mcg/m2) when dexmedetomidine or medetomidine is given IM For # lbs For # kg dose = mcg/kg volume = mL ANTISEDAN 4-7 2-3 400 0.15 7-9 3-4 350 0.2 9-11 4-5 300 0.3 11-22 5-10 250 0.4 22-29 10-13 230 0.5 29-33 13-15 210 0.6 33-44 15-20 200 0.7 44-55 20-25 180 0.8 55-66 25-30 170 0.9 66-73 30-33 160 1.0 73-81 33-37 150 1.1 81-99 37-45 145 1.2 99-110 45-50 140 1.3 110-121 50-55 135 1.4 121-132 55-60 130 1.5 132-143 60-65 128 1.6 143-154 65-70 125 1.7 154-176 70-80 123 1.8 >176 >80 120 1.9
Initial Dose: 25 mg/lb (55 mg/kg) of animal body weight.
Subsequent Daily Doses: 12.5 mg/lb (27.5 mg/kg) of animal body weight.
For ease of administration in animals of varying weights, 3 tablet sizes are provided. The following table indicates how dosage may be adjusted depending on tablet size and body weight. Subsequent doses should be given at 24-hour intervals.Tablet Size Approximate Animal Weight Initial Dose25 mg/lb(55 mg/kg) Subsequent Daily Doses12.5 mg/lb(27.5 mg/kg) 125 mg 5 lb (2.2 kg) 1 tablet 1/2 tablet 250 mg 10 lb (4.5 kg) 1 tablet 1/2 tablet 500 mg 20 lb (9.1 kg) 1 tablet 1/2 tablet
Treatment may be initiated with Albon Injection 40% to obtain effective blood levels almost immediately or to facilitate treatment of the fractious animal.
Length of treatment depends on the clinical response. In most cases treatment for 3–5 days is adequate. Treatment should be continued until the animal is asymptomatic for 48 hours.
DORMOSEDAN GEL produces sedation when administered sublingually at 0.018 mg/lb (0.040 mg/kg). DORMOSEDAN GEL must be placed beneath the tongue of the horse and is not meant to be swallowed. The dosing syringe delivers the product in 0.25 mL increments. The following dosing table may be used to determine the correct dose of DORMOSEDAN GEL (Table 1).Table 1: Sublingual dosing of DORMOSEDAN GEL Approximate body weight (lb) Range of doses (mg/lb) Approximate body weight (kg) Range of doses (mg/kg) Dose volume (mL) 330 - 439 0.023 – 0.017 150 - 199 0.051 – 0.038 1.00 440 - 549 0.022 – 0.017 200 - 249 0.047 – 0-038 1.25 550 – 659 0.021 – 0.017 250 – 299 0.046 – 0.038 1.50 660 - 769 0.020 – 0.017 300 – 349 0.044 – 0.038 1.75 770 - 879 0.019 – 0.017 350 – 399 0.043 – 0.038 2.00 880 - 989 0.019 – 0.017 400 – 449 0.043 – 0.038 2.25 990 - 1099 0.019 – 0.017 450 – 499 0.042 – 0.038 2.50 1100 - 1209 0.019 – 0.017 500 – 549 0.042 – 0.038 2.75 1210 - 1320 0.019 – 0.017 550 - 600 0.041 – 0.038 3.00
Use impermeable gloves when handling the product. Remove the syringe from the outer carton. While holding the plunger, turn the ring-stop on the plunger until the ring is able to slide freely up and down the plunger. Position the ring in such a way that the side nearest the barrel is at the desired volume marking. Turn the ring to secure it in place. Make sure that the horse's mouth contains no feed. Remove the cap from the tip of the syringe and save for cap replacement. Insert the syringe tip into the horse's mouth from the side of the mouth, placing the syringe tip beneath the tongue at the level of the commisure of the mouth. Depress the plunger until the ring-stop contacts the barrel, depositing the product beneath the tongue.
The following picture demonstrates correct administration of DORMOSEDAN GEL beneath the tongue.
Take the syringe out of the horse's mouth, recap the syringe and return it to the outer carton for disposal. Remove gloves for disposal.
For the best results, allow adequate time (a minimum of 40 minutes) between administration of DORMOSEDAN GEL and beginning the procedure. In general, horses show sedative effects lasting approximately 90-180 minutes.
Withhold food and water until the sedative effects of the product wear off.
Administer 3 mg pyrantel base per lb of body weight (6 mL Strongid T per 100 lb of body weight). For maximum control of parasitism, it is recommended that foals (2–8 months of age) be dosed every 4 weeks. To minimize potential hazard that the mare may pose to the foal, she should be treated 1 month prior to anticipated foaling date followed by retreatment 10 days to 2 weeks after birth of foal. Horses over 8 months of age should be routinely dosed every 6 weeks.
Directions for use
Strongid T may be administered by means of a stomach tube, dose syringe or by mixing into the feed.
Measure the appropriate dosage of Strongid T and mix in the desired quantity of water. Protect drench from direct sunlight and administer to the animal immediately following mixing. Do not attempt to store diluted suspension.
Strongid T is inactive against the common horse bot (Gasterophilus spp.) However, Strongid T may be administered concurrently with carbon disulfide observing the usual precautions with carbon disulfide.
Draw the appropriate dosage of Strongid T into a dose syringe and administer to the animal. Do not expose Strongid T to direct sunlight.
Mix the appropriate dosage of Strongid T in the normal grain ration. Fasting of animals prior to or following treatment is not required.
Administer 1 teaspoon (5 mL) for each 10 lb of body weight. It is not necessary to withhold food prior to or after treatment. Dogs usually find this dewormer very palatable and will lick the dose from the bowl willingly. If there is reluctance to accept the dose, mix in a small quantity of dog food to encourage consumption. It is recommended that dogs maintained under conditions of constant exposure to worm infestation should have a follow-up fecal exam within 2–4 weeks after treatment.
For maximum control and prevention of reinfestation, it is recommended that puppies be treated at 2, 3, 4, 6, 8, and 10 weeks of age. Lactating bitches should be treated 2–3 weeks after whelping. Adult dogs kept in heavily contaminated quarters may be treated at monthly intervals to prevent T. canis reinfestation.
The dosage of oxibendazole is 10 mg/kg (2.2 lb) of body weight (15 mg/kg for strongyloides). Each mark on the syringe delivers Anthelcide EQ to treat 100 lb (67 lb for strongyloides). Horses maintained on premises where reinfection is likely to occur should be retreated in 6–8 weeks.Dosage Table 10 mg/kg 15 mg/kg Syringe Mark Horse Weight (lb) Syringe Mark Horse Weight (lb) 100 100 300 200 200 200 600 400 400 400 900 600 600 600 1200 800 800 800 1000 1000 1200 1200
Anthelcide EQ is compatible with carbon disulfide, which can be used concurrently for bot control (Gasterophilus spp.) when administered by a veterinarian. Routine carbon disulfide cautions must be observed.
Strongid Paste is to be administered as a single oral dose of 3 mg pyrantel base per lb of body weight. The syringe has 4 weight mark increments. Each weight mark indicates the recommended dose for 300 lb of body weight.Dosage Body Weight Range Volume mg Pyrantel Base up to 300 lb 1/4 syringe (5 mL) 900 mg 301–600 lb 1/2 syringe (10 mL) 1800 mg 601–900 lb 3/4 syringe (15 mL) 2700 mg 901–1200 lb 1 full syringe (20 mL) 3600 mg
Note: Position screw-gauge over appropriate mark on plunger. Each mL contains 180 mg of pyrantel base as pyrantel pamoate.
For maximum control of parasitism, it is recommended that foals (2–8 months of age) be dosed every 4 weeks. To minimize the potential source of infection that the mare may pose to the foal, the mare should be treated 1 month prior to anticipated foaling date followed by retreatment 10 days to 2 weeks after birth of foal. Horses and ponies over 8 months of age should be routinely dosed every 6 weeks.
After removing the cap, the paste should be deposited on the dorsum of the tongue. Introduce the nozzle end of the syringe at the corner of the mouth. Direct the syringe backwards and depress the plunger to deposit the paste onto the tongue. Given in this manner, it is unlikely that rejection of the paste will occur. Raising the horse's head sometimes assists in the swallowing process. When only part of the paste has been used, replace the cap on the syringe nozzle.
The recommended minimum dose is 2.7 mg selamectin per pound (6 mg/kg) of body weight.
Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolution topically in accordance with the following tables. (See ADMINISTRATION for the recommended treatment intervals.)Cats (lb) Package color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1–15 Blue 45 mg 60 0.75 15.1–22 Taupe 60 mg 60 1.0
For cats over 22 lbs use the appropriate combination of tubes.Dogs (lb) Package color mg per tube Potency (mg/mL) Administered volume (mL) Up to 5 Mauve 15 mg 60 0.25 5.1–10 Purple 30 mg 120 0.25 10.1–20 Brown 60 mg 120 0.5 20.1–40 Red 120 mg 120 1.0 40.1–85 Teal 240 mg 120 2.0 85.1–130 Plum 360 mg 120 3.0
For dogs over 130 lbs use the appropriate combination of tubes.
Recommended for use in dogs 6 weeks of age and older and in cats 8 weeks of age and older.
A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolution topically to dogs and cats prior to first use.
Firmly press the cap down to puncture the seal on the Revolution tube; a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the animal 2 or more hours after treatment will not reduce the effectiveness of Revolution. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse.
Flea Control in Dogs and Cats
For the prevention and control of flea infestations, Revolution should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies >98% of fleas were killed within 36 hours. Results of clinical field studies using Revolution monthly demonstrated >90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with Revolution, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment.
If the dog or cat is already infested with fleas when the first dose of Revolution is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with Revolution because of the emergence of adult fleas from pupae.
Heartworm Prevention in Dogs and Cats
For the prevention of heartworm disease, Revolution must be administered on a monthly basis. Revolution may be administered year-round or at least within one month after the animal's first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of Revolution and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Revolution must be given within a month of the last dose of the former medication.
Selamectin, the active ingredient in Revolution, is a macrocyclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered >2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using Revolution beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at >8 weeks of age), or gaps of >2 months in the administration of Revolution during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms prior to the initiation of Revolution may be harboring pre-patent infections at the time Revolution was started. Testing such animals 3–4 months after initiation of Revolution would be necessary to confirm their negative heartworm status.
At the discretion of the veterinarian, cats ≥6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with Revolution. Cats already infected with adult heartworms can be given Revolution monthly to prevent further infections.
Ear Mite Treatment in Dogs and Cats
For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolution should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolution will control any subsequent ear mite infestations. In the clinical field trials ears were not cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the debris.
Sarcoptic Mange Treatment in Dogs
For the treatment of sarcoptic mange (S. scabiei) in dogs, Revolution should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolution will control any subsequent sarcoptic mange mite infestations. Because of the difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on resolution of clinical signs. Resolution of the pruritus associated with the mite infestations was observed in approximately 50% of the dogs 30 days after the first treatment and in approximately 90% of the dogs 30 days after the second monthly treatment.
Tick Control in Dogs
For the control of tick (Dermacentor variabilis) infestations in dogs, Revolution should be administered on a monthly basis. In heavy tick infestations, complete efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter.
Nematode Treatment in Cats
For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, Revolution should be applied once as a single topical dose.
IMPROVEST should be administered via subcutaneous injection into the post auricular region of the neck. A safety injector should be used, preferably one which has a dual safety system providing both a needle guard and a mechanism to prevent accidental operation of the trigger. Each intact male pig should receive two 2-mL doses of IMPROVEST. The first dose should be administered no earlier than 9 weeks of age. The second dose should be administered at least 4 weeks after the first dose. Pigs should be slaughtered no earlier than 4 weeks and no later than 8 weeks after the second dose. In case of misdosing, the animal should be re-dosed immediately.
DOSAGE AND ADMINISTRATION
Horse: The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100 lbs) of body weight once daily. Treatment may be given by intravenous or intramuscular injection and repeated for up to 5 days. Studies show onset of activity is within 2 hours. Peak response occurs between 12 and 16 hours and duration of activity is 24-36 hours. The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of body weight. Intravenous administration is recommended for prompt relief. Clinical studies show pain is alleviated in less than 15 minutes in many cases. Treatment may be repeated when signs of colic recur. During clinical studies approximately 10% of the horses required one or two additional treatments. The cause of colic should be determined and treated with concomitant therapy.
Cattle: The recommended dose for control of pyrexia associated with bovine respiratory disease and endotoxemia and control of inflammation in endotoxemia is 1.1 to 2.2 mg/kg (0.5 to 1.0 mg/lb; 1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration either once a day as a single dose or divided into two doses administered at 12-hour intervals for up to 3 days. The total daily dose should not exceed 2.2 mg/kg (1.0 mg/lb) of body weight. Avoid rapid intravenous administration of the drug.
The recommended dose for acute bovine mastitis is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) of body weight given once by intravenous administration.
The recommended dosage is 5 mg/lb of body weight. Administer twice daily for 5–7 days. Continue for 48 hours after all symptoms have subsided.
The recommended dosage is 50 mg (5–10 mg/lb). Administer once daily for 5–7 days. Continue for 48 hours after all symptoms have subsided.
DIRECTIONS FOR MIXING ORAL SUSPENSION
Add required amount of water (see following table) to the bottle and shake vigorously. Each mL of suspension will contain 50 mg of amoxicillin as the trihydrate.Bottle Size Amount of Water Required for Reconstitution 15 mL 12 mL 30 mL 23 mL
Note: Any unused portion of the reconstituted suspension must be discarded after 14 days. After mixing, refrigeration preferable, but not required.
Do Not Store Dry Powder at Temperatures Above 25°C (77°F)
For control of bacterial enteritis and bacterial pneumonia orally administer 1 tablet per 100 lb of body weight every 12 hours (5 mg/ lb of body weight daily in divided doses) for up to 4 consecutive days.
For treatment of bacterial enteritis and bacterial pneumonia orally administer 2 tablets per 100 lb of body weight every 12 hours (10 mg/lb of body weight daily in divided doses) for up to 4 consecutive days.
Dosage should continue until the animal returns to normal and for 24–48 hours after symptoms have subsided. Treatment should not exceed 4 consecutive days.
ADVOCIN is administered subcutaneously at either 8 mg/kg of body weight (2 mL/100 lb) as a one time injection, or at 6 mg/kg of body weight (1.5 mL/100 lb) with this treatment repeated once approximately 48 hours following the first injection. Care should be taken to dose accurately. Administered dose volume should not exceed 15 mL per injection site.ADVOCIN Dosage and Treatment Schedule Dose Volume (mL) Cattle Weight(lb) 6 mg/kg, given twice,48 hours apart 8 mg/kg given once * Administered dose volume should not exceed 15 mL per injection site. 50 0.75 1 100 1.5 2 150 2.25 3 200 3 4 250 3.75 5 300 4.5 6 400 6 8 500 7.5 10 600 9 12 700 10.5 14 800 12 16* 900 13.5 18* 1000 15 20*
The recommended dosage is 6.25 mg/lb (1 mL/10 lb) of body weight twice a day. Skin and soft tissue infections such as abscesses, cellulitis, wounds, superficial/juvenile pyoderma, and periodontal infections should be treated for 5–7 days or for 48 hours after all symptoms have subsided. If no response is seen after 5 days of treatment, therapy should be discontinued and the case reevaluated. Deep pyoderma may require treatment for 21 days; the maximum duration of treatment should not exceed 30 days.
The recommended dosage is 62.5 mg (1 mL) twice a day. Skin and soft tissue infections such as abscesses and cellulitis/dermatitis should be treated for 5–7 days or 48 hours after all symptoms have subsided, not to exceed 30 days. If no response is seen after 3 days of treatment, therapy should be discontinued and the case reevaluated.
Urinary tract infections may require treatment for 10–14 days or longer. The maximum duration of treatment should not exceed 30 days.
Reconstitution Instructions - Oral Suspension
Add 14 mL of water to the 15-mL bottle and shake vigorously. Each mL of suspension will contain 50 mg of amoxicillin activity as the trihydrate and 12.5 mg of clavulanic acid activity as the potassium salt.
Note: Any unused portion of the reconstituted suspension must be discarded after 10 days. Refrigeration of the reconstituted suspension is required.
The same dosage schedule may be followed for both antipruritic and antitussive therapy.Weight of Dog Initial Dosage Up to 10 lb 1/2 tablet, twice daily 11–20 lb 1 tablet, twice daily 21–40 lb 2 tablets, twice daily Over 40 lb 3 tablets, twice daily
After 4 days, reduce dosage to 1/2 of the initial dose or to an amount just sufficient to maintain remission of symptoms. Individual animal response will vary and dosage should be adjusted until proper response is obtained.
For animals up to 500 lb, use 1 fl oz of Drench Concentrate. For animals over 500 lb, use 2 fl oz of Drench Concentrate.
Preferred Plus Arthritis Pain
Administer an initial oral dose of 25 mg/lb (55 mg/kg) of body weight on the first day of treatment. Administer subsequent daily doses at the rate of 12.5 mg/lb (27.5 mg/kg) of body weight. Continue treatment for at least 2 days after remission of clinical signs. Do not extend treatment for more than 21 consecutive days. Suggested dosage schedules follow:Body Weight (lb)Up To No. of TabletsFirst Day No. of TabletsSubsequent Days Primor 120 5 1 1/2 10 2 1 15 3 1 1/2 Primor 240 10 1 1/2 20 2 1 30 3 1 1/2 Primor 600 25 1 1/2 50 2 1 Primor 1200 50 1 1/2 100 2 1
For optimal therapeutic effect: (1) the drug must be given early in the course of the disease; (2) therapeutically effective levels must be maintained in the body throughout the treatment period; (3) treatment should continue for at least 2 days after remission of clinical signs; and (4) the causative bacterial agents must be sensitive to the drug.
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