Pfizer Labs

Pfizer Labs Drugs

• Minizide
  

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  Minizide

  

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  MINIZIDE (prazosin hydrochloride/polythiazide)

  Dosage: as determined by individual titration of MINIPRESS (prazosin hydrochloride) and RENESE (polythiazide). (See box warning.)

  Usual MINIZIDE dosage is one capsule two or three times daily, the strength depending upon individual requirement following titration.

  The following is a general guide to the administration of the individual components of MINIZIDE:

  MINIPRESS (prazosin hydrochloride)

  Initial Dose

  1 mg two or three times a day. (See WARNINGS.)

  Maintenance Dose

  Dosage may be slowly increased to a total daily dose of 20 mg given in divided doses. The therapeutic dosages most commonly employed have ranged from 6 mg to 15 mg daily given in divided doses. Doses higher than 20 mg usually do not increase efficacy, however a few patients may benefit from further increases up to a daily dose of 40 mg given in divided doses. After initial titration some patients can be maintained adequately on a twice daily dosage regimen.

  Use With Other Drugs

  When adding a diuretic or other antihypertensive agent, the dose of MINIPRESS should be reduced to 1 mg or 2 mg three times a day and retitration then carried out.

  RENESE (polythiazide)

  The usual dose of RENESE for antihypertensive therapy is 2 to 4 mg daily.

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