Absorption of nickel sulphate is variable among individuals. For maximum absorption, tablets should be taken orally at the beginning of the day (or any convenient time after having taken nothing but water for at least 7 hours). Take nothing but water for one hour after taking medication to aid absorption.
Weight
Starting Dose
Max Daily Dose
40-80 lbs
½ tablet
1 ½ tablet
80-120 lbs
1 tablet
3 tablets
120-160 lbs
1 ½ tablets
4 ½ tablets
160-200 lbs
2 tablets
6 tablets
200-240 lbs
2 ½ tablets
7 ½ tablets
Over 240 lbs
3 tablets
9 tablets
In the setting of renal impairment
Dosage should be adjusted and serum nickel and bromide levels should be followed. Steady state trough level should be drawn prior to ingesting the day's dose after one week of dosing or at appropriate intervals. Target trough serum nickel level is 30-60 mcg/L. (Caution: post dose peak levels are unreliable.)
Maintenance phase
In order to maintain symptomatic relief, medication may be continued at the same or reduced initial phase dose level. Treatment duration depends on the individual. For allergic nickel dermatitis, continue 2 tablets 1 hour prior to breakfast for weeks 7 – 16. (Refer to Hypersensitivity section above). Some patients may require continued or intermittent repeated treatment to maintain nickel desensitization.