Relypsa, Inc.

Relypsa, Inc. Drugs

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  Tussin Maximum Strength

  

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  2.1 General Information

  Administer Veltassa at least 6 hours before or 6 hours after other oral medications [see Warnings and Precautions (5.1) and Drug Interactions (7)].

  Administer Veltassa with food. Do not heat Veltassa (e.g., microwave) or add to heated foods or liquids. Do not take Veltassa in its dry form.

  2.2 Recommended Dosing and Titration

  The recommended starting dose of Veltassa is 8.4 grams patiromer once daily. Monitor serum potassium and adjust the dose of Veltassa based on the serum potassium level and the desired target range. The dose may be increased or decreased, as necessary, to reach the desired serum potassium concentration, up to a maximum dose of 25.2 grams once daily. The dose can be up-titrated based on serum potassium level at 1-week or longer intervals, in increments of 8.4 grams.

  2.3 Preparation of Veltassa

  Prepare each dose immediately prior to administration following the steps below:

  Step 1: Add about 1 ounce (30 milliliters) of water to an empty glass or cup. Step 2: Empty the entire contents of the packet(s) into the glass or cup. Step 3: Stir the mixture thoroughly. Step 4: Add an additional 2 ounces (60 milliliters) of water to the glass or cup containing the mixture. Step 5: Stir the mixture thoroughly; the powder will not dissolve and the mixture will look cloudy. Step 6: Drink the mixture immediately. If some powder remains in the glass after drinking, add more water, stir and drink immediately. Repeat as needed to ensure the entire dose is administered.

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