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Hydrocodone Bitatrate A...

Hydrocodone Bitatrate And Acetaminophen

Dosage should be adjusted according to the severity of the pain and the response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.

The usual adult dosage is one tablet every four to six hours as needed for pain. The total daily dose should not exceed 6 tablets.
Hydrocodone Bitartrate ...

Hydrocodone Bitartrate And Acetaminophen

Dosage should be adjusted according to the severity of pain and response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.

The usual adult dosage for Hydrocodone Bitartrate and Acetaminophen Tablets USP is:
Product Strength Usual Adult Dosage as needed for pain The total 24-hour dosage should not exceed 5 mg/325 mg One to two tablets every four to six hours 12 tablets 5 mg/500 mg One to two tablets every four to six hours 8 tablets 7.5 mg/325 mg One tablet every four to six hours 8 tablets 7.5 mg/500 mg One tablet every four to six hours 6 tablets 7.5 mg/650 mg One tablet every four to six hours 6 tablets 7.5 mg/750 mg One tablet every four to six hours 5 tablets 10 mg/325 mg One tablet every four to six hours 6 tablets 10 mg/500 mg One tablet every four to six hours 6 tablets 10 mg/650 mg One tablet every four to six hours 6 tablets 10 mg/660 mg One tablet every four to six hours 6 tablets 10 mg/750 mg One tablet every four to six hours 5 tablets
Lorazepam

Lorazepam

Lorazepam is administered orally. For optimal results, dose, frequency of administration, and duration of therapy should be individualized according to patient response. To facilitate this, 0.5 mg, 1 mg and 2 mg tablets are available.

The usual range is 2 to 6 mg/day given in divided doses, the largest dose being taken before bedtime, but the daily dosage may vary from 1 to 10 mg/day.

For anxiety, most patients require an initial dose of 2 to 3 mg/day given b.i.d. or t.i.d.

For insomnia due to anxiety or transient situational stress, a single daily dose of 2 to 4 mg may be given, usually at bedtime.

For elderly or debilitated patients, an initial dosage of 1 to 2 mg/day in divided doses is recommended, to be adjusted as needed and tolerated.

The dosage of Lorazepam should be increased gradually when needed to help avoid adverse effects. When higher dosage is indicated, the evening dose should be increased before the daytime doses.
Lorcet Plus

Lorcet Plus

Dosage should be adjusted according to the severity of the pain and the response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.

The usual adult dosage is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 6 tablets.
Lortab

Lortab

Dosage should be adjusted according to severity of pain and response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.

The usual adult dosage is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 6 tablets.
Lortab

Lortab

Dosage should be adjusted according to severity of pain and response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.

The usual adult dosage is one or two tablets every four to six hours as needed for pain. The total daily dosage should not exceed 8 tablets.
Percocet

Percocet

Dosage should be adjusted according to the severity of the pain and the response of the patient. It may occasionally be necessary to exceed the usual dosage recommended below in cases of more severe pain or in those patients who have become tolerant to the analgesic effect of opioids. If pain is constant, the opioid analgesic should be given at regular intervals on an around-the-clock schedule. PERCOCET tablets are given orally.

PERCOCET 2.5 mg/325 mg The usual adult dosage is one or 2 tablets every 6 hours. The total daily dose of acetaminophen should not exceed 4 grams.

PERCOCET 5 mg/325 mg; PERCOCET 7.5 mg/500 mg; PERCOCET 10 mg/650 mg The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.

PERCOCET 7.5 mg/325 mg; PERCOCET 10 mg/325 mg The usual adult dosage is one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.
Strength Maximal Daily Dose PERCOCET 2.5 mg/325 mg 12 Tablets PERCOCET 5 mg/325 mg 12 Tablets PERCOCET 7.5 mg/325 mg 8 Tablets PERCOCET 7.5 mg/500 mg 8 Tablets PERCOCET 10 mg/325 mg 6 Tablets PERCOCET 10 mg/650 mg 6 Tablets
Cessation of Therapy

In patients treated with PERCOCET tablets for more than a few weeks who no longer require therapy, doses should be tapered gradually to prevent signs and symptoms of withdrawal in the physically dependent patient.
Lortab

Lortab

Dosage should be adjusted according to severity of pain and response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.

The usual adult dosage is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 6 tablets.
Lorcet 10650

Lorcet 10650

Dosage should be adjusted according to the severity of the pain and the response of the patient. However, it should be kept in mind that tolerance to hydrocodone can develop with continued use and that the incidence of untoward effects is dose related.

The usual adult dosage is one tablet every four to six hours as needed for pain. The total daily dosage should not exceed 6 tablets.
Lanoxin

Lanoxin

2.1 Important Dosing Information

In selecting a LANOXIN dosing regimen, it is important to consider factors that affect digoxin blood levels (e.g., body weight, age, renal function, concomitant drugs) since toxic levels of digoxin are only slightly higher than therapeutic levels. Dosing can be either initiated with a loading dose followed by maintenance dosing if rapid titration is desired or initiated with maintenance dosing without a loading dose.

Consider interruption or reduction in digoxin dose prior to electrical cardioversion [see Warnings and Precautions (5.6)].

Use digoxin solution to obtain the appropriate dose in infants, young pediatric patients, or patients with very low body weight.

2.2 Loading Dosing Regimen in Adults and Pediatric Patients

For adults and pediatric patients if a loading dosage is to be given, administer half the total loading dose initially, then ¼ the loading dose every 4 to 8 hours twice, with careful assessment of clinical response and toxicity before each dose. The recommended loading dose is displayed in Table 1.
Table 1. Recommended LANOXIN Oral Loading Dose mcg = micrograms
Age

     Oral Loading Dose, mcg/kg

5 to 10 years

20 - 45

Adults and pediatric patients over 10 years

10 - 15

2.3 Maintenance Dosing in Adults and Pediatric Patients Over 10 Years Old

The maintenance dose is based on the lean body weight, renal function, age, and concomitant products [see Drug Interactions (7.1, 7.2, 7.3)].

The recommended starting maintenance dosage in adults and pediatric patients over 10 years old is displayed in Table 2. Doses may be increased every 2 weeks according to clinical response, serum drug levels, and toxicity.
Table 2. Recommended Starting LANOXIN Maintenance Dosage in Adults and Pediatric Patients Over 10 Years Old mcg = micrograms
Age

     Oral Maintenance Dose, mcg/kg/day      (given once daily)

Adults and pediatric patients over 10 years

3.4 – 5.1

Table 3 displays the recommended (once daily) maintenance dose of LANOXIN in pediatric patients over 10 years old and adult patients according to lean body weight and renal function. The doses are based on studies in adult patients with heart failure. Alternatively, the maintenance dose may be estimated by the following formula (peak body stores lost each day through elimination):

Total Maintenance Dose = Loading Dose (i.e., Peak Body Stores) x % Daily Loss/100(% Daily Loss = 14 + Creatinine clearance/5)

Reduce the dose of LANOXIN in patients whose lean weight is an abnormally small fraction of their total body mass because of obesity or edema.
Table 3. Recommended Maintenance Dose (in micrograms given once daily) of LANOXIN in Pediatric Patients Over 10 Years Old and Adults by Lean Body Weight and by Renal Functiona a  Doses are rounded to the nearest dose possible using whole and/or half LANOXIN tablets. Recommended doses approximately 30 percent lower than the calculated dose are designated with an *. Monitor digoxin levels in patients receiving these initial doses and increase dose if needed.b  For adults, creatinine clearance was corrected to 70-kg body weight or 1.73 m2 body surface area. If only serum creatinine concentrations (Scr) are available, a corrected Ccr may be estimated in men as (140 – Age)/Scr. For women, this result should be multiplied by 0.85. For pediatric patients, the modified Schwartz equation may be used. The formula is based on height in cm and Scr in mg/dL where k is a constant. Ccr is corrected to 1.73 m2 body surface area. During the first year of life, the value of k is 0.33 for pre-term babies and 0.45 for term infants. The k is 0.55 for pediatric patients and adolescent girls and 0.7 for adolescent boys.GFR (mL/min/1.73 m2) = (k x Height)/Scrc  If no loading dose administered.d  The doses listed assume average body composition.
Corrected Creatinine Clearanceb

Number of   Days Before   Steady StateAchievedc

Lean Body Weightd

   kg

40

50

60

70

80

90

100

lb

88

110

132

154

176

198

220

10 mL/min

62.5*

125

125

187.5

187.5

187.5

250

19

20 mL/min

125

125

125

187.5

187.5

250

250

16

30 mL/min

125

125

187.5

187.5

250

250

312.5

14

40 mL/min

125

187.5

187.5

250

250

312.5

312.5

13

50 mL/min

125

187.5

187.5

250

250

312.5

312.5

12

60 mL/min

125

187.5

250

250

312.5

312.5

375

11

70 mL/min

187.5

187.5

250

250

   312.5

375

375

10

80 mL/min

187.5

   187.5

250

312.5

312.5

375

437.5

9

90 mL/min

187.5

250

250

312.5

375

437.5

   437.5

8

   100 mL/min

   187.5

250

   312.5

   312.5

375

   437.5

500

7

2.4 Maintenance Dosing in Pediatric Patients Less Than 10 Years Old

The starting maintenance dose for heart failure in pediatric patients less than 10 years old is based on the lean body weight, renal function, age, and concomitant products [see Drug Interactions (7.1, 7.2, 7.3)]. The recommended starting maintenance dose for pediatric patients between 5 and 10 years old with normal renal function is displayed in Table 4.
Table 4. Recommended Starting LANOXIN Maintenance Dosage in Pediatric Patients Between 5 and 10 Years Old
Age

Daily Oral    Maintenance Dose,    mcg/kg/day

       Dose Regimen,        mcg/kg/dose

5 to 10 years

6.4 – 12.9

3.2 – 6.4   Twice daily

The recommended maintenance dose (to be given twice daily) is presented in Table 5.
Table 5. Recommended Maintenance Dose (in micrograms given twice daily) of LANOXIN in Pediatric Patients <10 Years of Agea Based upon Lean Body Weight and Renal Functiona,b a  Recommended are doses to be given twice daily.b  The doses are rounded to the nearest dose possible using whole and/or half LANOXIN tablets. Recommended doses approximately 30 percent lower than the calculated dose are designated with an *. Monitor digoxin levels in patients receiving these initial doses and increase dose if needed.c  The modified Schwartz equation may be used to estimate creatinine clearance. See footnote b under Table 2.d  If no loading dose administered.
Corrected Creatinine Clearancec

Number of   Days Before   Steady StateAchievedd

Lean Body Weight

   kg

20

30

40

50

60

lb

44

66

88

110

132

10 mL/min

-

62.5

62.5*

125

125

19

20 mL/min

62.5

62.5

125

125

125

16

30 mL/min

62.5

62.5*

125

125

187.5

14

40 mL/min

62.5

   62.5*

125

187.5

187.5

13

50 mL/min

62.5

125

125

187.5

187.5

12

60 mL/min

62.5

125

125

187.5

250

11

70 mL/min

62.5

125

187.5

187.5

250

10

80 mL/min

62.5*

125

187.5

   187.5

250

9

90 mL/min

62.5*

125

187.5

250

250

8

   100 mL/min

   62.5*

125

   187.5

250

   312.5

7

2.5 Monitoring to Assess Safety, Efficacy, and Therapeutic Blood Levels

Monitor for signs and symptoms of digoxin toxicity and clinical response. Adjust dose based on toxicity, efficacy, and blood levels.

Serum digoxin levels < 0.5 ng/mL have been associated with diminished efficacy, while levels above 2 ng/mL have been associated with increased toxicity without increased benefit.

Interpret the serum digoxin concentration in the overall clinical context, and do not use an isolated measurement of serum digoxin concentration as the basis for increasing or decreasing the LANOXIN dose. Serum digoxin concentrations may be falsely elevated by endogenous digoxin-like substances [see Drug Interactions (7.4)]. If the assay is sensitive to these substances, consider obtaining a baseline digoxin level before starting LANOXIN and correct post-treatment values by the reported baseline level.

Obtain serum digoxin concentrations just before the next scheduled LANOXIN dose or at least 6 hours after the last dose. The digoxin concentration is likely to be 10% to 25% lower when sampled right before the next dose (24 hours after dosing) compared to sampling 8 hours after dosing (using once-daily dosing). However, there will be only minor differences in digoxin concentrations using twice daily dosing whether sampling is done at 8 or 12 hours after a dose.

2.6 Switching from Intravenous Digoxin to Oral Digoxin

When switching from intravenous to oral digoxin formulations, make allowances for differences in bioavailability when calculating maintenance dosages (see Table 6).
Table 6. Comparison of the Systemic Availability and Equivalent Doses of Oral and Intravenous LANOXIN
Absolute   Bioavailability

   Equivalent Doses (in micrograms)

LANOXIN Tablets

60 - 80%

   62.5

125

250

500

LANOXIN Intravenous Injection

100%

50

   100

   200

   400
Fioricet

Fioricet

1 or 2 capsules every 4 hours as needed. Total daily dosage should not exceed 6 capsules.

Extended and repeated use of this product is not recommended because of the potential for physical dependence.

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Rx Pak Division Of Mckesson Corporation Drugs