Vista Pharmaceuticals, Inc.

Vista Pharmaceuticals, Inc. Drugs

• Isoxsuprine Hydrochlori...
  

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  Isoxsuprine Hydrochloride

  

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  10 to 20mg three or four times daily

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• Sulfamethoxazole And Tr...
  

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  Sulfamethoxazole And Trimethoprim

  

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  DOSAGE AND ADMINISTRATION

  Not recommended for use in pediatric patients less than 2 months of age.

  Urinary Tract Infections and Shigellosis in Adults and Pediatric Patients, and Acute Otitis Media in Children

  Adults: The usual adult dosage in the treatment of urinary tract infections is 1 sulfamethoxazole and trimethoprim DS (double strength) tablet every 12 hours for 10 to 14 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.Children: The recommended dose for children with urinary tract infections or acute otitis media is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days. An identical daily dosage is used for 5 days in the treatment of shigellosis. The following table is a guideline for the attainment of this dosage:

  Children 2 months of age and older:

  Weight

  Dose – every 12 hours

  lb

  kg

  Tablets

  22

  10

  -

  44

  20

  1

  66

  30

  1 ½

  88

  40

  2 or 1 DS tablet

  For Patients with Impaired Renal Function

  When renal function is impaired, a reduced dosage should be employed using the following table:

  Creatinine Clearance (mL/min)

  Recommended Dosage Regimen

  Above 30

  Usual standard regimen

  15-30

  1/2 the usual regimen

  Below 15

  Use not recommended

  Acute Exacerbations of Chronic Bronchitis in Adults

  The usual adult dosage in the treatment of acute exacerbations of chronic bronchitis is 1 sulfamethoxazole and trimethoprim double strength tablet or 2 sulfamethoxazole and trimethoprim tablets every 12 hours for 14 days.

  Pneumocystis Carinii Pneumonia

  Treatment: Adults and Children:The recommended dosage for patients with documented Pneumocystis carinii pneumonia is 75 to 100 mg/kg sulfamethoxazole and 15 to 20 mg/kg trimethoprim per 24 hours given in equally divided doses every 6 hours for 14 to 21 days11. The following table is a guideline for the upper limit of this dosage.

  Weight

  Dose – every 6 hours

  lb

  kg

  Tablets

  18

  8

  -

  35

  16

  1

  53

  24

  1 ½

  70

  32

  2 or 1 DS tablet

  88

  40

  2 ½

  106

  48

  3 or 1 ½ DS tablets

  141

  64

  4 or 2 DS tablets

  176

  80

  5 or 2 ½ DS tablets

  For the lower limit dose (75 mg/kg sulfamethoxazole and 15 mg/kg trimethoprim per 24 hours) administer 75% of the dose in the above table.Prophylaxis AdultsThe recommended dosage for prophylaxis in adults is 1 sulfamethoxazole and trimethoprim DS (double strength) tablet daily12 ChildrenFor children, the recommended dose is 750 mg/m2/day sulfamethoxazole with 150 mg/m2/day trimethoprim given orally in equally divided doses twice a day, on 3 consecutive days per week.The total daily dose should not exceed 1600 mg sulfamethoxazole and 320 mg trimethoprim13 The following table is a guideline for the attainment of this dosage in children:

  Body Surface Area

  Dose – every 12 hours

  (m2)

  Tablets

  0.26

  -

  0.53

  ½

  1.06

  1

  Traveler’s Diarrhea in Adults For the treatment of traveler’s diarrhea, the usual adult dosage is 1 sulfamethoxazole and trimethoprim DS (double strength) tablet or 2 sulfamethoxazole and trimethoprim tablets every 12 hours for 5 days.

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