Dechra Veterinary Products
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Dechra Veterinary Products Drugs
The volume and rate of infusion will depend upon the clinical condition, existing deficits of the animal, maintenance needs and continuing losses. Generally aim to correct hypovolaemia by 50% initially (ideally over 6 hours but faster if necessary) and reassess by clinical examination.
Deficits are generally in the range of 50 ml/kg (mild) to 150 ml/kg (severe). An infusion rate of 15 ml/kg/hour is recommended in the absence of shock (range 5-75 ml/kg/hour).
In shock, high initial infusion rates, up to 90 ml/kg/hour, are needed. High infusion rates should not be continued for longer than 1 hour unless renal function and urine output are restored. The maximum infusion rate should be decreased in the presence of cardiac, renal and pulmonary disease.
DOSAGE: The initial recommended dose is 0.1 mg/10 lb. (4.5 kg) body weight twice daily. Dosage is then adjusted by monitoring the thyroid blood levels of the dog every four weeks until an adequate maintenance dose is established. The usual maintenance dose is 0.1 mg/10 lb. (4.5 kg) once daily.
ADMINISTRATION: LEVOCRINE™ Chewable Tablets (levothyroxine sodium) may be administered orally or placed in the food.
The starting dose of FELIMAZOLE Coated Tablets is 2.5 mg administered every 12 hours. Following 3 weeks of treatment, the dose should be titrated to effect based on individual serum total T4 (TT4) levels and clinical response. Dose adjustments should be made in 2.5 mg increments. The maximum total dosage is 20 mg per day divided, not to exceed 10 mg as a single administration.
Hematology, biochemistry, and TT4 should be evaluated prior to initiating treatment and monitored after 3 weeks and 6 weeks of treatment. Thereafter, bloodwork should be monitored every 3 months and the dose adjusted as necessary. Cats receiving doses greater than 10 mg per day should be monitored more frequently.
Orally administer 0.5 mg/lb (1.1 mg/kg) once daily starting 10 to 15 days prior to Expected Foaling Date (EFD). Treatment may be continued for up to 5 days after foaling if mares are not producing adequate milk after foaling.Determine the appropriate dose for the body weight of the mare based on the dosing table below. One cc will treat 220 lb (100 kg) of body weight. Table 1. Dosing Table Weight(lb) Weight(kg) cc Domperidone(mg) 550-660 250-300 3 330 661-880 301-400 4 440 881-1100 401-500 5 550 1101-1320 501-600 6 660 Turn the dial ring until the edge of the ring nearest the tip of the syringe lines up with the dose to be delivered. Remove the syringe cap. Make sure the horse's mouth is free of food or other obstructions. Insert the nozzle of the syringe through the interdental space of the horse's mouth and deposit the gel on the back of the tongue by depressing the plunger. Recap the syringe.
This is a 25 cc multi-dose syringe. Please note that for subsequent doses, it will be necessary to adjust for previous doses. For example, if the intended dose for a horse is 5 cc, then the dial ring is set at 5 cc for the first dose, at 10 cc for the second dose, at 15 cc for the third dose, at 20 cc for the fourth dose, and at 25 cc for the fifth dose.
Prior to treatment, the lesion should be cleansed. Muricin® ointment should be applied to the affected area twice a day. Apply a sufficient amount of ointment to completely cover the infected area. Maximum duration of treatment should not exceed 30 days.
Frequency of administration is dependent on the severity of the condition. For mild inflammations, application may range from once daily to once a week; for severe conditions Animax Cream may be applied as often as 2 to 3 times daily, if necessary. Frequency of treatment may be decreased as improvement occurs. Clean affected areas, removing any encrusted discharge or exudate. Apply Animax Cream (Nystatin-Neomycin Sulfate- Thiostrepton-Triamcinolone Acetonide Cream USP) sparingly in a thin film.
The external ear should be thoroughly cleaned and dried before treatment. Remove foreign material, debris, crusted exudates, etc., with suitable non-irritating solutions. Excessive hair should be clipped from the treatment area. After verifying that the eardrum is intact, instill 4 drops from the 7.5 g and 15 g tube of Vetromax twice daily into the ear canal of dogs weighing less than 30 lbs. Instill 8 drops from the 7.5 g and 15 g tube twice daily into the ear canal of dogs weighing 30 lbs. or more. Massage external ear canal carefully after instillation to ensure appropriate distribution of medication. Therapy should continue for 7 consecutive days.
DOSAGE AND ADMINISTRATION: Prior to treatment, remove excessivehair and clean the lesion and adjacent area. Hold bottle upright 3 to 6inches from the lesion and depress the sprayer head twice. Administer 2to 4 times daily for 7 days.Each depression of the sprayer head delivers 0.7 mL of GentamicinSulfate With Betamethasone Valerate Topical Spray.
Frequency of administration is dependent on the severity of the condition. For mild inflammations, application may range from once daily to once a week; for severe conditions Animax Ointment may be applied as often as two to three times daily, if necessary.
Frequency of treatment may be decreased as improvement occurs.
Wear gloves during the administration of the ointment or wash hands immediately after application.
Clean ear canal of impacted cerumen. Inspect canal and remove any foreign bodies such as grass awns, ticks, etc. Instill three to five drops of Animax Ointment.
Preliminary use of a local anesthetic may be advisable.
Infected Anal Glands, Cystic Areas, etc.
Drain gland or cyst and then fill with Animax Ointment.
Other Dermatologic Disorders
Clean affected areas, removing any encrusted discharge or exudate. Apply Animax Ointment (Nystatin-Neomycin Sulfate-Thiostrepton-Triamcinolone Acetonide Ointment) sparingly in a thin film.
Always provide the Client Information Sheet with prescription.
The starting dose for the treatment of hyperadrenocorticism in dogs is 1.0-3.0 mg/lb (2.2-6.7 mg/kg) once a day based on body weight and capsule size (see Table 1). VETORYL Capsules should be administered with food.Table 1: Starting dose Weight range (pounds) Weight range (kg) Starting dose (mg) ONCE DAILY * Dogs over 132 pounds (60 kg) should be administered the appropriate combination of capsules. ≥ 3.8 to < 10 ≥ 1.7 to < 4.5 10 ≥ 10 to < 22 ≥ 4.5 to < 10 30 ≥ 22 to < 44 ≥ 10 to < 20 60 ≥ 44 to < 88 ≥ 20 to < 40 120 ≥ 88 to < 132* ≥ 40 to < 60* 180 (1 × 120 mg and 1 × 60 mg)
After approximately 10-14 days at this dose, re-examine the dog and conduct a 4-6 hour post-dosing ACTH stimulation test. If physical examination is acceptable, take action according to Table 2.Table 2: Action at 10-14 day evaluation Post-ACTH serum cortisol Action µg/dL nmol/L * Combinations of capsule sizes should be used to slowly increase the once daily dose. < 1.45 < 40 Stop treatment. Re-start at a decreased dose 1.45 to 5.4 40 to 150 Continue on same dose > 5.4 to 9.1 > 150 to 250 EITHER: Continue on current dose if clinical signs are well controlledOR: Increase dose if clinical signs of hyperadrenocorticism are still evident* > 9.1 > 250 Increase initial dose
Individual dose adjustments and close monitoring are essential. Re-examine and conduct an ACTH stimulation test 10-14 days after every dose alteration. Care must be taken during dose increases to monitor the dog's clinical signs and serum electrolyte concentrations. Once daily administration is recommended. However, if clinical signs are not controlled for the full day, twice daily dosing may be needed. To switch from a once daily dose to a twice daily dose, increase the total daily dose by 1/3 to 1/2 and divide the total amount into two doses given 12 hours apart.
Long Term Monitoring
Once an optimum dose of VETORYL Capsules has been reached, re-examine the dog at 30 days, 90 days and every 3 months thereafter. At a minimum, this monitoring should include a thorough history and physical examination, ACTH stimulation test (conducted 4-6 hours after VETORYL Capsule administration), and serum biochemical tests (with particular attention to electrolytes, renal and hepatic function). A post-ACTH stimulation test resulting in a cortisol of < 1.45 µg/dL (< 40 nmol/L), with or without electrolyte abnormalities, may precede the development of clinical signs of hypoadrenocorticism. Good control is indicated by favorable clinical signs as well as post-ACTH serum cortisol of 1.45-9.1 µg/dL (40-250 nmol/L).
If the ACTH stimulation test is < 1.45 µg/dL (< 40 nmol/L) and/or if electrolyte imbalances characteristic of hypoadrenocorticism (hyperkalemia and hyponatremia) are found, VETORYL Capsules should be temporarily discontinued until recurrence of clinical signs consistent with hyperadrenocorticism and test results return to normal (1.45-9.1 µg/dL or 40-250 nmol/L). VETORYL Capsules may then be re-introduced at a lower dose.
Owners should be instructed to stop therapy and contact their veterinarian immediately in the event of adverse reactions or unusual developments.
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Administer 1.8 mg/kg by intramuscular injection up to a maximum dose of 900 mg per horse. Divide the total volume evenly into three separate injection sites. Discard unused vial contents. OSPHOS is provided in a single use vial and does not contain a preservative.
Clinical improvement is most evident at 2 months post-treatment (see Effectiveness). Of the horses that responded to treatment with OSPHOS in the field study, 65% maintained their level of improvement through the 6 month evaluation.
If there is no response to initial therapy, the horse should be re-evaluated. For horses that initially respond to OSPHOS but do not maintain their clinical improvement for 6 months, OSPHOS may be re-administered at 3 to 6 month intervals based on recurrence of clinical signs. For horses that respond to OSPHOS and maintain clinical improvement for 6 months, OSPHOS should be re-administered after clinical signs recur.
DIRECTIONS: Many cats will accept Cat Lax® readily. For finicky animals place a small amount on paw - cat will lick his paw and become accustomed to the pleasant taste.
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