The practitioner should choose a volume of Sodium Bicarbonate Inj., 8.4% USP Neutralizing Additive Solution to be mixed with Lidocaine w/ Epinephrine in a ratio of 1:10 (local anesthetic solution to sodium bicarbonate solution).The below table provides a mixing guide showing for convenience the volumes of 8.4% Sodium Bicarbonate Neutralizing Additive Solution to be added to the commercial preparations of Lidocaine with Epinephrine in order to achieve a mixed ratio of 10:1.
10:1 Anesthetic-to-Bicarbonate Solution Ratio Mixing Guide for 10:1
Volume (mL), Lidocaine w/ Epinephrine (container type)
Volume (mL), 8.4% Sodium Bicarbonate Solution
1.8 mL (cartridge)
20 mL (Vial)
30 mL (Vial)
50 mL (Vial)