Orchid Chemicals & Pharmaceuticals Limited

Orchid Chemicals & Pharmaceuticals Limited Drugs

• Rompe Pecho Cf
  

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  Rompe Pecho Cf

  

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  The dosage of memantine hydrochloride shown to be effective in controlled clinical trials is 20 mg/day.

  The recommended starting dose of memantine hydrochloride is 5 mg once daily. The recommended target dose is 20 mg/day. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice a day), 15 mg/day (5 mg and 10 mg as separate doses), and 20 mg/day (10 mg twice a day). The minimum recommended interval between dose increases is one week.

  Memantine hydrochloride can be taken with or without food.

  Doses in Special Populations

  A target dose of 5 mg BID is recommended in patients with severe renal impairment (creatinine clearance of 5 to 29 mL/min based on the Cockroft-Gault equation):

  For males: CLcr = [140-age (years)] · Weight (kg)/[72 · serum creatinine (mg/dL)]

  For females: CLcr = 0.85 · [140-age (years)] · Weight (kg)/[72 · serum creatinine (mg/dL)]

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