Sti Pharma Llc

Sti Pharma Llc Drugs

• Dexamethasone Elixir
  

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  Dexamethasone Elixir

  

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  For oral administration

  DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE AND THE RESPONSE OF THE PATIENT.

  The initial dosage varies from 0.75 to 9 mg a day depending on the disease being treated. In less severe diseases doses lower than 0.75 mg may suffice, while in severe diseases doses higher than 9 mg may be required. The initial dosage should be maintained or adjusted until the patient's response is satisfactory. If satisfactory clinical response does not occur after a reasonable period of time, discontinue dexamethasone elixir and transfer the patient to other therapy.

  After a favorable initial response, the proper maintenance dosage should be determined by decreasing the initial dosage in small amounts to the lowest dosage that maintains an adequate clinical response.

  Patients should be observed closely for signs that might require dosage adjustment, including changes in clinical status resulting from remissions or exacerbations of the disease, individual drug responsiveness, and the effect of stress (e.g., surgery, infection, trauma). During stress it may be necessary to increase dosage temporarily.

  If the drug is to be stopped after more than a few days of treatment, it usually should be withdrawn gradually. The following milligram equivalents facilitate changing to dexamethasone elixir from other glucocorticoids:

  DEXAMETHASONE ELIXIR METHYLPREDNISOLONEAND TRIAMCINOLONE PREDNISOLONEANDPREDNISONE HYDROCORTISONE CORTISONE 0.75 mg = 4 mg = 5 mg = 20 mg = 25 mg

  Dexamethasone suppression tests

  Tests for Cushing's syndrome Give 1 mg of dexamethasone orally at 11:00 p.m. Blood is drawn for plasma cortisol determination at 8:00 a.m. the following morning. For greater accuracy, give 0.5 mg of dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion. Test to distinguish Cushing's syndrome due to pituitary ACTH excess from Cushing's syndrome due to other causes. Give 2 mg of dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion.

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• Dexamethasone Elixir
  

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  Dexamethasone Elixir

  

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  For oral administration

  DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE AND THE RESPONSE OF THE PATIENT.

  The initial dosage varies from 0.75 to 9 mg a day depending on the disease being treated. In less severe diseases doses lower than 0.75 mg may suffice, while in severe diseases doses higher than 9 mg may be required. The initial dosage should be maintained or adjusted until the patient's response is satisfactory. If satisfactory clinical response does not occur after a reasonable period of time, discontinue dexamethasone elixir and transfer the patient to other therapy.

  After a favorable initial response, the proper maintenance dosage should be determined by decreasing the initial dosage in small amounts to the lowest dosage that maintains an adequate clinical response.

  Patients should be observed closely for signs that might require dosage adjustment, including changes in clinical status resulting from remissions or exacerbations of the disease, individual drug responsiveness, and the effect of stress (e.g., surgery, infection, trauma). During stress it may be necessary to increase dosage temporarily.

  If the drug is to be stopped after more than a few days of treatment, it usually should be withdrawn gradually. The following milligram equivalents facilitate changing to dexamethasone elixir from other glucocorticoids:

  DEXAMETHASONE ELIXIR METHYLPREDNISOLONEAND TRIAMCINOLONE PREDNISOLONEANDPREDNISONE HYDROCORTISONE CORTISONE 0.75 mg = 4 mg = 5 mg = 20 mg = 25 mg

  Dexamethasone suppression tests

  Tests for Cushing's syndrome Give 1 mg of dexamethasone orally at 11:00 p.m. Blood is drawn for plasma cortisol determination at 8:00 a.m. the following morning. For greater accuracy, give 0.5 mg of dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion. Test to distinguish Cushing's syndrome due to pituitary ACTH excess from Cushing's syndrome due to other causes. Give 2 mg of dexamethasone orally every 6 hours for 48 hours. Twenty-four hour urine collections are made for determination of 17-hydroxycorticosteroid excretion.

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• Ethambutol Hydrochlorid...
  

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  Ethambutol Hydrochloride

  

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  ETHAMBUTOL HCI should not be used alone, in initial treatment or in tretreatment. ETHAMBUTOL HCI should be administered on a once every 24-hour basis only. Absorption is not significantly altered by administration with food. Therapy, in general, should be continued until bacteriological conversion has become permanent and maximal clinical improvement has occurred.

  ETHAMBUTOL HCI is not recommended for use in pediatric patients under thirteen years of age since safe conditions for use have not been established.

  Initial Treatment: In patients who have not received previous antituberculous therapy, administer ETHAMBUTOL HCI 15 mg/kg (7 mg/lb) of body weight, as a single oral dose once every 24 hours. In the more recent studies, isoniazid has been administered concurrently in a single, daily, oral dose.

  Retreatment: In patients who have received previous antituberculous therapy, administer ETHAMBUTOL HCI 25 mg/kg (11 mg/lb) of body weight, as a single oral dose once every 24 hours. Concurrently administer at least one other antituberculous drug to which the organisms have been demonstrated to be susceptible by appropriate in vitro tests. Suitable drugs usually consist of those not previously used in the treatment of the patient. After 60 days of ETHAMBUTOL HCI administration, decrease the dose to 15 mg/kg (7mg/lb) of body weight, and administer as a single oral dose once every 24 hours.

  During the period when a patient is on a daily dose of 25 mg/kg, monthly eye examinations are advised.

  See Table for easy selection of proper weight-dose tablet(s).

  Weight-Dose Table 15 mg/kg (7 mg/lb) Schedule Weight Range Pounds Kilograms Dose In mg Under 85 Under 37…………. ……………….500 85 – 94.5 37 – 43 ................. ……………….600 95 – 109.5 43 – 50 ................. ……………….700 110– 124.5 50 – 57 ................. ……………….800 125– 139.5 57 – 64 ................. ……………….900 140– 154.5 64 – 71 ................. ……………..1000 155– 169.5 71 – 79 ................. ……………..1100 170 – 184.5 79 – 84 ................. ……………..1200 185– 199.5 84 – 90 ................. ……………..1300 200– 214.5 90 – 97 ................. ……………..1400 215 and Over Over 97 ................ ……………..1500 25 mg/kg (11 mg/lb) Schedule Under 85 Under 38............... ……………..900 85 – 92.5 38 – 42................. ……………..1000 93 – 101.5 42 – 45.5............... ……………..1100 102– 109.5 45.5 – 50............... ……………..1200 110 – 118.5 50 – 54................. ……………..1300 119 – 128.5 54 – 58................. ……………..1400 129 – 136.5 58 – 62................. ……………..1500 137 – 146.5 62 – 67................. ……………..1600 147 – 155.5 67 – 71................. ……………..1700 156 – 164.5 71 – 75................. ……………..1800 165– 173.5 75 – 79................. ……………..1900 174– 182.5 79 – 83................. ……………..2000 183– 191.5 83 – 87................. ……………..2100 192– 199.5 87 – 91................. ……………..2200 200– 209.5 91 – 95................. ……………..2300 210– 218.5 95 – 99................. ……………..2400 219 and Over Over 99................. ……………..2500

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• Triacin-c
  

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  Triacin-c

  

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  DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND RESPONSE OF THE PATIENT.

  Usual Dose:

  Teaspoonfuls (5 mL)

  Adults and children 12 years and older

  2 teaspoonfuls (10 mL) every 4 to 6 hours, not to exceed 8 teaspoonfuls (40 mL) in 24 hours.

  Children 6 to under 12 years

  1 teaspoonful (5 mL) every 4 to 6 hours, not to exceed 4 teaspoonfuls (20 mL) in 24 hours.

  Children 2 to under 6 years

  ½ teaspoonful (2.5 mL) every 4 to 6 hours, not to exceed 2 teaspoonfuls

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• Sulfatrim
  

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  Sulfatrim

  

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  Not recommended for use in pediatric patients less than 2 months of age.

  Urinary Tract Infections and Shigellosis in Adults and Pediatric Patients, and Acute Otitis Media in Children

  Adults

  The usual adult dosage in the treatment of urinary tract infections is four teaspoonfuls (20mL) Sulfamethoxazole and trimethoprim oral suspension every 12 hours for 10 to 14 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.

  Children

  The recommended dose for children with urinary tract infections or acute otitis media is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days. An identical daily dosage is used for 5 days in the treatment of shigellosis. The following table is a guideline for the attainment of this dosage:

  Children 2 months of age or older:

  Weight Dose - every 12 hours lb kg Teaspoonfuls 22 10 1 (5 mL) 44 20 2 (10 mL) 66 30 3 (15 mL) 88 40 4 (20 mL)

  For Patients with Impaired Renal Function: When renal function is impaired, a reduced dosage should be employed using the following table:

  Creatinine Clearance (mL/min) Recommended Dosage Regimen Above 30 Use standard regimen 15 to 30 ½ the usual regimen Below 15 Use not recommended

  Acute Exacerbations of Chronic Bronchitis in Adults

  The usual adult dosage in the treatment of acute exacerbations of chronic bronchitis is four teaspoonfuls (20 mL) sulfamethoxazole and trimethoprim oral suspension every 12 hours for 14 days.

  Pneumocystis Carinii Pneumonia

  Treatment

  Adults and Children: The recommended dosage for treatment of patients with documented Pneumocystis carinii pneumonia is 75 to 100 mg/kg sulfamethoxazole and 15 to 20 mg/kg trimethoprim per 24 hours given in equally divided doses every 6 hours for 14 to 21 days.10 The following table is a guideline for the upper limit of this dosage:

  Weight Dose - every 6 hours lb kg Teaspoonfuls 18 8 1 (5 mL) 35 16 2 (10 mL) 53 24 3 (15 mL) 70 32 4 (20 mL) 88 40 5 (25 mL) 106 48 6 (30 mL) 141 64 8 (40 mL) 176 80 10 (50 mL)

  For the lower limit dose (75 mg/kg sulfamethoxazole and 15 mg/kg trimethoprim per 24 hours) administer 75% of the dose in the above table.

  Prophylaxis

  Adults

  The recommended dosage for prophylaxis in adults is four teaspoonfuls (20 mL) of the oral suspension daily.11

  Children

  For children, the recommended dose is 750 mg/m2/day sulfamethoxazole with 150 mg/m2/day trimethoprim given orally in equally divided doses twice a day, on 3 consecutive days per week. The total daily dose should not exceed 1600 mg sulfamethoxazole and 320 mg trimethoprim.12 The following table is a guideline for the attainment of this dosage in children:

  Body Surface Area Dose - every 12 hours (m2) Teaspoonfuls 0.26 ½ (2.5 mL) 0.53 1 (5 mL) 1.06 2 (10 mL)

  Travelers’ Diarrhea in Adults

  For the treatment of travelers' diarrhea, the usual adult dosage is four teaspoonfuls (20 mL) of sulfamethoxazole and trimethoprim oral suspension every 12 hours for 5 days.

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• Escitalopram
  

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  Escitalopram

  

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  Escitalopram tablets, USP should be administered once daily, in the morning or evening, with or without food.

  2.1 Major Depressive Disorder

  Initial Treatment

  Adolescents

  The recommended dose of escitalopram tablets, USP is 10 mg once daily. A flexible-dose trial of escitalopram tablets (10 to 20 mg/day) demonstrated the effectiveness of escitalopram tablets, USP [see Clinical Studies (14.1)]. If the dose is increased to 20 mg, this should occur after a minimum of 3 weeks.

  Adults

  The recommended dose of escitalopram tablets, USP is 10 mg once daily. A fixed-dose trial of escitalopram tablets, USP demonstrated the effectiveness of both 10 mg and 20 mg of escitalopram tablets, USP, but failed to demonstrate a greater benefit of 20 mg over 10 mg [see Clinical Studies (14.1)]. If the dose is increased to 20 mg, this should occur after a minimum of one week.

  Maintenance Treatment

  It is generally agreed that acute episodes of major depressive disorder require several months or longer of sustained pharmacological therapy beyond response to the acute episode. Systematic evaluation of continuing escitalopram tablets, USP 10 or 20 mg/day in adults patients with major depressive disorder who responded while taking escitalopram tablets, USP during an 8-week, acute-treatment phase demonstrated a benefit of such maintenance treatment [see Clinical Studies (14.1)]. Nevertheless, the physician who elects to use escitalopram tablets, USP for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient. Patients should be periodically reassessed to determine the need for maintenance treatment.

  2.2 Generalized Anxiety Disorder

  Initial Treatment

  Adults

  The recommended starting dose of escitalopram tablets, USP is 10 mg once daily. If the dose is increased to 20 mg, this should occur after a minimum of one week.

  Maintenance Treatment

  Generalized anxiety disorder is recognized as a chronic condition. The efficacy of escitalopram oxalate in the treatment of GAD beyond 8 weeks has not been systematically studied. The physician who elects to use escitalopram tablets, USP for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient.

  2.3 Special Populations

  10 mg/day is the recommended dose for most elderly patients and patients with hepatic impairment.

  No dosage adjustment is necessary for patients with mild or moderate renal impairment. Escitalopram tablets, USP should be used with caution in patients with severe renal impairment.

  2.4 Discontinuation of Treatment with Escitalopram Tablets, USP

  Symptoms associated with discontinuation of escitalopram oxalate and other SSRIs and SNRIs have been reported [see Warnings and Precautions (5.3)]. Patients should be monitored for these symptoms when discontinuing treatment. A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Subsequently, the physician may continue decreasing the dose but at a more gradual rate.

  2.5 Switching Patients To or From a Monoamine Oxidase Inhibitor

  At least 14 days should elapse between discontinuation of an MAOI intended to treat psychiatric disorders and initiation of therapy with escitalopram tablets. Conversely, at least 14 days should be allowed after stopping escitalopram tablets before starting an MAOI intended to treat psychiatric disorders [see Contraindications (4.1)].

  2.6 Use of Escitalopram Tablets with Other MAOIs such as Linezolid or Methylene Blue

  Do not start escitalopram tablets in a patient who is being treated with linezolid or intravenous methylene blue because there is an increased risk of serotonin syndrome. In a patient who requires more urgent treatment of a psychiatric condition, other interventions, including hospitalization, should be considered [see Contraindications (4.1)].

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• Hydroxyzine Hcl Solutio...
  

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  Hydroxyzine Hcl Solution

  

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  For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested: Adults, 50-100 mg q.i.d.; children under 6 years, 50 mg daily in divided doses; children over 6 years, 50-100 mg daily in divided doses.

  For use in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses and in histamine-mediated pruritus: Adults 25 mg t.i.d. or q.i.d.; children under 6 years, 50 mg daily in divided doses; children over 6 years, 50-100 mg daily in divided doses.

  As a sedative when used as a premedication and following general anesthesia: 50-100 mg for adults; and 0.6 mg/kg of body weight in children.

  When treatment is initiated by the intramuscular route of administration, subsequent doses may be administered orally.

  As with all medications, the dosage should be adjusted according to patient’s response to therapy.

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