Triprolidine and pseudoephedrine hydrochlorides and codeine phosphate syrup should be used with considerable caution in patients with increased intraocular pressure (narrow angle glaucoma), stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, bladder neck obstruction, hypertension, diabetes mellitus, ischemic heart disease, and hyperthyroidism.
In the presence of head injury or other intracranial lesions, the respiratory depressant effects of codeine and other narcotics may be markedly enhanced, as well as their capacity for elevating cerebrospinal fluid pressure.
Narcotics also produce other CNS depressant effects, such as drowsiness, that may further obscure the clinical course of patients with head injuries.
Codeine or other narcotics may obscure signs on which to judge the diagnosis or clinical course of patients with acute abdominal conditions.
There is currently no manufacturer warning information available for this drug.
Triprolidine and pseudoephedrine hydrochlorides and codeine phosphate syrup is indicated for temporary relief of coughs and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.
Each 5 mL (one teaspoonful) of syrup for oral administration contains:
Codeine Phosphate……10 mg
WARNING: May be habit forming.
Triprolidine Hydrochloride……1.25 mg
Pseudoephedrine Hydrochloride……30 mg
Alcohol 4.3%. Added as preservatives: Sodium Benzoate 0.1%, Methylparaben 0.15%.
Triprolidine and pseudoephedrine hydrochlorides and codeine phosphate syrup produces antitussive, antihistaminic and nasal decongestant effects. The components have the following chemical names and structural formulas:
Codeine Phosphate, USP
[IC]7,8-didehydro-4,5 α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate (1:1) (salt) hemihydrate[/IC]
Triprolidine Hydrochloride, USP
[IC](E)-2-[3(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloride monohydrate[/IC]
Pseudoephedrine Hydrochloride, USP
[IC]Benzenemethanol, α-[1-(methylamino)ethyl]-,[S-(R*, R*)]- hydrochloride[/IC]
