Wilshire Pharmaceuticals, Inc.

Wilshire Pharmaceuticals, Inc. Drugs

• Nitroglycerin Lingual
  

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  Nitroglycerin Lingual

  

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  At the onset of an attack, one or two metered sprays should be administered onto or under the tongue. No more than three metered sprays are recommended within a 15-minute period. If the chest pain persists, prompt medical attention is recommended. Nitroglycerin Lingual Spray may be used prophylactically five to ten minutes prior to engaging in activities which might precipitate an acute attack.

  Each metered spray of Nitroglycerin Lingual Spray delivers 48 mg of solution containing 400 mcg of nitroglycerin after an initial priming of 5 sprays. It will remain adequately primed for 6 weeks. If the product is not used within 6 weeks it can be adequately reprimed with 1 spray. Longer storage periods without use may require up to 5 repriming sprays. There are 60 or 200 metered sprays per bottle. The total number of available doses is dependent, however, on the number of sprays per use (1 or 2 sprays), and the frequency of repriming.

  The transparent container can be used for continuous monitoring of the consumption. The end of the pump should be covered by the fluid level. Once fluid falls below the level of the center tube, sprays will not be adequate and the container should be replaced. As with all other sprays, there is a residual volume of fluid at the bottom of the bottle which cannot be used.

  During application the patient should rest, ideally in the sitting position. The container should be held vertically with the valve head uppermost and the spray orifice as close to the mouth as possible. The dose should preferably be sprayed onto the tongue by pressing the button firmly and the mouth should be closed immediately after each dose. THE SPRAY SHOULD NOT BE INHALED. The medication should not be expectorated or the mouth rinsed for 5 to 10 minutes following administration. Patients should be instructed to familiarize themselves with the position of the spray orifice, which can be identified by the finger rest on top of the valve, in order to facilitate orientation for administration at night.

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• Rizatriptan Benzoate
  

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  Rizatriptan Benzoate

  

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  LAMOTRIGINE EXTENDED-RELEASE TABLETS are taken once daily, with or without food. Tablets must be swallowed whole and must not be chewed, crushed, or divided.

  2.1 General Dosing Considerations

  Rash

  There are suggestions, yet to be proven, that the risk of severe, potentially life-threatening rash may be increased by (1) coadministration of LAMOTRIGINE EXTENDED-RELEASE TABLETS with valproate, (2) exceeding the recommended initial dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS, or (3) exceeding the recommended dose escalation for LAMOTRIGINE EXTENDED-RELEASE TABLETS. However, cases have occurred in the absence of these factors [see Boxed Warning]. Therefore, it is important that the dosing recommendations be followed closely.

  The risk of nonserious rash may be increased when the recommended initial dose and/or the rate of dose escalation for LAMOTRIGINE EXTENDED-RELEASE TABLETS is exceeded and in patients with a history of allergy or rash to other AEDs.

  It is recommended that LAMOTRIGINE EXTENDED-RELEASE TABLETS not be restarted in patients who discontinued due to rash associated with prior treatment with lamotrigine unless the potential benefits clearly outweigh the risks. If the decision is made to restart a patient who has discontinued LAMOTRIGINE EXTENDED-RELEASE TABLETS, the need to restart with the initial dosing recommendations should be assessed. The greater the interval of time since the previous dose, the greater consideration should be given to restarting with the initial dosing recommendations. If a patient has discontinued lamotrigine for a period of more than 5 half-lives, it is recommended that initial dosing recommendations and guidelines be followed. The half-life of lamotrigine is affected by other concomitant medications [see Clinical Pharmacology (12.3)].

  LAMOTRIGINE EXTENDED-RELEASE TABLETS Added to Drugs Known to Induce or Inhibit Glucuronidation

  Because lamotrigine is metabolized predominantly by glucuronic acid conjugation, drugs that are known to induce or inhibit glucuronidation may affect the apparent clearance of lamotrigine. Drugs that induce glucuronidation include carbamazepine, phenytoin, phenobarbital, primidone, rifampin, estrogen-containing oral contraceptives, and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir. Valproate inhibits glucuronidation. For dosing considerations for LAMOTRIGINE EXTENDED-RELEASE TABLETS in patients on estrogen-containing contraceptives and atazanavir/ritonavir, see below and Table 5. For dosing considerations for LAMOTRIGINE EXTENDED-RELEASE TABLETS in patients on other drugs known to induce or inhibit glucuronidation, see Table 1 and Table 5.

  Target Plasma Levels

  A therapeutic plasma concentration range has not been established for lamotrigine. Dosing of LAMOTRIGINE EXTENDED-RELEASE TABLETS should be based on therapeutic response [see Clinical Pharmacology (12.3)].

  Women Taking Estrogen-Containing Oral Contraceptives

  Starting LAMOTRIGINE EXTENDED-RELEASE TABLETS in Women Taking Estrogen-Containing Oral Contraceptives: Although estrogen-containing oral contraceptives have been shown to increase the clearance of lamotrigine [see Clinical Pharmacology (12.3)], no adjustments to the recommended dose-escalation guidelines for LAMOTRIGINE EXTENDED-RELEASE TABLETS should be necessary solely based on the use of estrogen-containing oral contraceptives. Therefore, dose escalation should follow the recommended guidelines for initiating adjunctive therapy with LAMOTRIGINE EXTENDED-RELEASE TABLETS based on the concomitant AED or other concomitant medications (see Table 1). See below for adjustments to maintenance doses of LAMOTRIGINE EXTENDED-RELEASE TABLETS in women taking estrogen-containing oral contraceptives.

  Adjustments to the Maintenance Dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS in Women Taking Estrogen-Containing Oral Contraceptives:

  (1) Taking Estrogen-Containing Oral Contraceptives: In women not taking carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Clinical Pharmacology (12.3)], the maintenance dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS will in most cases need to be increased by as much as 2-fold over the recommended target maintenance dose to maintain a consistent lamotrigine plasma level. (2) Starting Estrogen-Containing Oral Contraceptives: In women taking a stable dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS and not taking carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Clinical Pharmacology (12.3)], the maintenance dose will in most cases need to be increased by as much as 2-fold to maintain a consistent lamotrigine plasma level. The dose increases should begin at the same time that the oral contraceptive is introduced and continue, based on clinical response, no more rapidly than 50 to 100 mg/day every week. Dose increases should not exceed the recommended rate (see Table 1) unless lamotrigine plasma levels or clinical response support larger increases. Gradual transient increases in lamotrigine plasma levels may occur during the week of inactive hormonal preparation (pill-free week), and these increases will be greater if dose increases are made in the days before or during the week of inactive hormonal preparation. Increased lamotrigine plasma levels could result in additional adverse reactions, such as dizziness, ataxia, and diplopia. If adverse reactions attributable to LAMOTRIGINE EXTENDED-RELEASE TABLETS consistently occur during the pill-free week, dose adjustments to the overall maintenance dose may be necessary. Dose adjustments limited to the pill-free week are not recommended. For women taking LAMOTRIGINE EXTENDED-RELEASE TABLETS in addition to carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Clinical Pharmacology (12.3)], no adjustment to the dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS should be necessary. (3) Stopping Estrogen-Containing Oral Contraceptives: In women not taking carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Clinical Pharmacology (12.3)], the maintenance dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS will in most cases need to be decreased by as much as 50% in order to maintain a consistent lamotrigine plasma level. The decrease in dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS should not exceed 25% of the total daily dose per week over a 2-week period, unless clinical response or lamotrigine plasma levels indicate otherwise [see Clinical Pharmacology (12.3)]. In women taking LAMOTRIGINE EXTENDED-RELEASE TABLETS in addition to carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation [see Drug Interactions (7), Clinical Pharmacology (12.3)], no adjustment to the dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS should be necessary.

  Women and Other Hormonal Contraceptive Preparations or Hormone Replacement Therapy

  The effect of other hormonal contraceptive preparations or hormone replacement therapy on the pharmacokinetics of lamotrigine has not been systematically evaluated. It has been reported that ethinylestradiol, not progestogens, increased the clearance of lamotrigine up to 2-fold, and the progestin-only pills had no effect on lamotrigine plasma levels. Therefore, adjustments to the dosage of LAMOTRIGINE EXTENDED-RELEASE TABLETS in the presence of progestogens alone will likely not be needed.

  Patients Taking Atazanavir/Ritonavir

  While atazanavir/ritonavir does reduce the lamotrigine plasma concentration, no adjustments to the recommended dose-escalation guidelines for LAMOTRIGINE EXTENDED-RELEASE TABLETS should be necessary solely based on the use of atazanavir/ritonavir. Dose escalation should follow the recommended guidelines for initiating adjunctive therapy with LAMOTRIGINE EXTENDED-RELEASE TABLETS based on concomitant AED or other concomitant medications (see Tables 1 and 5). In patients already taking maintenance doses of LAMOTRIGINE EXTENDED-RELEASE TABLETS and not taking glucuronidation inducers, the dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS may need to be increased if atazanavir/ritonavir is added, or decreased if atazanavir/ritonavir is discontinued [see Clinical Pharmacology (12.3)].

  Patients with Hepatic Impairment

  Experience in patients with hepatic impairment is limited. Based on a clinical pharmacology study in 24 subjects with mild, moderate, and severe liver impairment [see Use in Specific Populations (8.6), Clinical Pharmacology (12.3)], the following general recommendations can be made. No dosage adjustment is needed in patients with mild liver impairment. Initial, escalation, and maintenance doses should generally be reduced by approximately 25% in patients with moderate and severe liver impairment without ascites and 50% in patients with severe liver impairment with ascites. Escalation and maintenance doses may be adjusted according to clinical response.

  Patients with Renal Impairment

  Initial doses of LAMOTRIGINE EXTENDED-RELEASE TABLETS should be based on patients' concomitant medications (see Table 1); reduced maintenance doses may be effective for patients with significant renal impairment [see Use in Specific Populations (8.7), Clinical Pharmacology (12.3)]. Few patients with severe renal impairment have been evaluated during chronic treatment with immediate-release lamotrigine. Because there is inadequate experience in this population, LAMOTRIGINE EXTENDED-RELEASE TABLETS should be used with caution in these patients.

  Discontinuation Strategy

  For patients receiving LAMOTRIGINE EXTENDED-RELEASE TABLETS in combination with other AEDs, a re-evaluation of all AEDs in the regimen should be considered if a change in seizure control or an appearance or worsening of adverse reactions is observed.

  If a decision is made to discontinue therapy with LAMOTRIGINE EXTENDED-RELEASE TABLETS, a step-wise reduction of dose over at least 2 weeks (approximately 50% per week) is recommended unless safety concerns require a more rapid withdrawal [see Warnings and Precautions (5.8)].

  Discontinuing carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce lamotrigine glucuronidation should prolong the half-life of lamotrigine; discontinuing valproate should shorten the half-life of lamotrigine.

  2.2 Adjunctive Therapy for Primary Generalized Tonic-Clonic and Partial-Onset Seizures

  This section provides specific dosing recommendations for patients aged 13 years and older. Specific dosing recommendations are provided depending upon concomitant AEDs or other concomitant medications.

  Table 1. Escalation Regimen for LAMOTRIGINE EXTENDED-RELEASE TABLETS in Patients Aged 13 Years and Older In Patients TAKING Valproate* In Patients NOT TAKING Carbamazepine, Phenytoin, Phenobarbital, Primidone,† or Valproate* In Patients TAKING Carbamazepine, Phenytoin, Phenobarbital, or Primidone† and NOT TAKING Valproate* * Valproate has been shown to inhibit glucuronidation and decrease the apparent clearance of lamotrigine [see Drug Interactions (7), Clinical Pharmacology (12.3)]. † Drugs that induce lamotrigine glucuronidation and increase clearance, other than the specified antiepileptic drugs, include estrogen-containing oral contraceptives, rifampin, and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir. Dosing recommendations for oral contraceptives and the protease inhibitor atazanavir/ritonavir can be found in General Dosing Considerations [see Dosage and Administration (2.1)]. Patients on rifampin and the protease inhibitor lopinavir/ritonavir should follow the same dosing titration/maintenance regimen used with antiepileptic drugs that induce glucuronidation and increase clearance [see Dosage and Administration (2.1), Drug Interactions (7), and Clinical Pharmacology (12.3)]. ‡ Dose increases at week 8 or later should not exceed 100 mg daily at weekly intervals. Weeks 1 and 2 25 mg every other day 25 mg every day 50 mg every day Weeks 3 and 4 25 mg every day 50 mg every day 100 mg every day Week 5 50 mg every day 100 mg every day 200 mg every day Week 6 100 mg every day 150 mg every day 300 mg every day Week 7 150 mg every day 200 mg every day 400 mg every day Maintenance range (week 8 and onward) 200 to 250 mg every day‡ 300 to 400 mg every day‡ 400 to 600 mg every day‡

  2.3 Conversion from Adjunctive Therapy to Monotherapy

  The goal of the transition regimen is to attempt to maintain seizure control while mitigating the risk of serious rash associated with the rapid titration of LAMOTRIGINE EXTENDED-RELEASE TABLETS.

  To avoid an increased risk of rash, the recommended maintenance dosage range of LAMOTRIGINE EXTENDED-RELEASE TABLETS as monotherapy is 250 to 300 mg given once daily.

  The recommended initial dose and subsequent dose escalations for LAMOTRIGINE EXTENDED-RELEASE TABLETS should not be exceeded [see Boxed Warning].

  Conversion from Adjunctive Therapy with Carbamazepine, Phenytoin, Phenobarbital, or Primidone to Monotherapy with LAMOTRIGINE EXTENDED-RELEASE TABLETS

  After achieving a dose of 500 mg/day of LAMOTRIGINE EXTENDED-RELEASE TABLETS using the guidelines in Table 1, the concomitant enzyme-inducing AED should be withdrawn by 20% decrements each week over a 4-week period. Two weeks after completion of withdrawal of the enzyme-inducing AED, the dosage of LAMOTRIGINE EXTENDED-RELEASE TABLETS may be decreased no faster than 100 mg/day each week to achieve the monotherapy maintenance dosage range of 250 to 300 mg/day.

  The regimen for the withdrawal of the concomitant AED is based on experience gained in the controlled monotherapy clinical trial using immediate-release lamotrigine.

  Conversion from Adjunctive Therapy with Valproate to Monotherapy With LAMOTRIGINE EXTENDED-RELEASE TABLETS

  The conversion regimen involves the 4 steps outlined in Table 2.

  Table 2. Conversion from Adjunctive Therapy with Valproate to Monotherapy with LAMOTRIGINE EXTENDED-RELEASE TABLETS in Patients Aged 13 Years and Older with Epilepsy LAMOTRIGINE EXTENDED-RELEASE TABLETS Valproate Step 1 Achieve a dose of 150 mg/day according to guidelines in Table 1. Maintain established stable dose. Step 2 Maintain at 150 mg/day. Decrease dose by decrements no greater than 500 mg/day/week to 500 mg/day and then maintain for 1 week. Step 3 Increase to 200 mg/day. Simultaneously decrease to 250 mg/day and maintain for 1 week. Step 4 Increase to 250 or 300 mg/day. Discontinue.

  Conversion from Adjunctive Therapy with Antiepileptic Drugs other than Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate to Monotherapy with LAMOTRIGINE EXTENDED-RELEASE TABLETS

  After achieving a dosage of 250 to 300 mg/day of LAMOTRIGINE EXTENDED-RELEASE TABLETS using the guidelines in Table 1, the concomitant AED should be withdrawn by 20% decrements each week over a 4-week period. No adjustment to the monotherapy dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS is needed.

  2.4 Conversion from Immediate-Release Lamotrigine Tablets to LAMOTRIGINE EXTENDED-RELEASE TABLETS

  Patients may be converted directly from immediate-release lamotrigine to LAMOTRIGINE EXTENDED-RELEASE TABLETS. The initial dose of LAMOTRIGINE EXTENDED-RELEASE TABLETS should match the total daily dose of immediate-release lamotrigine. However, some subjects on concomitant enzyme-inducing agents may have lower plasma levels of lamotrigine on conversion and should be monitored [see Clinical Pharmacology (12.3)].

  Following conversion to LAMOTRIGINE EXTENDED-RELEASE TABLETS, all patients (but especially those on drugs that induce lamotrigine glucuronidation) should be closely monitored for seizure control [see Drug Interactions (7)]. Depending on the therapeutic response after conversion, the total daily dose may need to be adjusted within the recommended dosing instructions (see Table 1).

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• Amlodipine And Valsarta...
  

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  Amlodipine And Valsartan

  

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  Amphetamines should be administered at the lowest effective dosage and dosage should be individually adjusted. Late evening doses should be avoided because of the resulting insomnia.

  Narcolepsy

  Usual dose is 5 to 60 mg per day in divided doses, depending on the individual patient response.

  Narcolepsy seldom occurs in children under 12 years of age; however, when it does, dextroamphetamine sulfate may be used. The suggested initial dose for patients aged 6 to 12 is 5 mg daily; daily dose may be raised in increments of 5 mg at weekly intervals until optimal response is obtained. In patients 12 years of age and older, start with 10 mg daily; daily dosage may be raised in increments of 10 mg at weekly intervals until an optimal response is obtained. If bothersome adverse reactions appear (e.g., insomnia or anorexia), dosage should be reduced. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours.

  Attention Deficit Disorder with Hyperactivity

  Not recommended for pediatric patients under 3 years of age.

  In pediatric patients from 3 to 5 years of age, start with 2.5 mg daily; daily dosage may be raised in increments of 2.5 mg at weekly intervals until optimal response is obtained.

  In pediatric patients 6 years of age and older, start with 5 mg once or twice daily; daily dosage may be raised in increments of 5 mg at weekly intervals until optimal response is obtained. Only in rare cases will it be necessary to exceed a total of 40 mg per day.

  Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours.

  Where possible, drug administration should be interrupted occasionally to determine if there is a recurrence of behavioral symptoms sufficient to require continued therapy.

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