Flumeglumine

DOSE AND ADMINISTRATION

Horse:  The recommended dose for musculoskeletal disorders is 0.5 mg per pound (1 mL/100lbs) of body weight once daily.  Treatment may be given by intravenous or intramuscular injection and repeated for up to 5 days.  Studies show onset of activity is within 2 hours.  Peak response occurs between 12 and 16 hours and duration of activity is 24-36 hours.  The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg per pound of  body weight.  Intravenous administration is recommended for prompt relief.  Clinical studies show pain is alleviated in less than 15 minutes in many cases.  Treatment may be repeated when signs of colic recur.  During clinical studies approximately 10% of the horses required one or two additional treatments.  The cause of colic should be determined and treated with concomitant therapy.

Cattle:  The recommended dose for control of pyrexia associated with bovine respiratory disease and endotoxemia and control of inflammation in endotoxemia is 1.1 to 2.2 mg/kg (0.5 to 1.0 mg/lb; 1 to 2 mL per 100 lbs) of body weight given by slow intravenous administration either once a day as a single dose or divided into two doses administered at a 12-hour intervals for up to 3 days.  The total daily dose should not exceed 2.2 mg/kg (1.0 mg/lb) of body weight.  Avoid rapid intravenous administration of the drug.

The recommended dose for acute bovine mastitis is 2.2 mg/kg (1 mg/lb; 2 mL per 100 lbs) of body weight given once by intravenous administration.