Prolonged use of a topical ocular anesthetic is not recommended. It may produce permanent corneal opacification with accompanying visual loss.
There is currently no manufacturer warning information available for this drug.
For procedures requiring a disclosing agent in combination with a topical ophthalmic anesthetic agent such as tonometry, gonioscopy, removal of corneal foreign bodies and other short corneal or conjunctival procedures.
Fluorescein Sodium and Benoxinate Hydrochloride Ophthalmic Solution USP, 0.25%/0.4% is a disclosing agent with rapid anesthetic action and short duration.
Fluorescein sodium is represented by the following structural formula:
C20H10Na2O5
Mol. Wt. 376.28
Chemical Name: Spiro (isobenzofuran-1 (3H),9′-(9H) xanthene)-3-one, 3′,6′ dihydroxy-, disodium salt.
Benoxinate hydrochloride is represented by the following structural formula:
C17H28N2O3 • HCl
Mol. Wt. 344.88
Chemical Name: 2-(Diethylamino) ethyl 4-amino-3-butoxybenzoate monohydrochloride.
Each mL Contains: ACTIVES: Fluorescein Sodium 2.5 mg (0.25%), Benoxinate Hydrochloride 4 mg (0.4%); INACTIVES: Boric Acid, Povidone, Purified Water. Hydrochloric Acid may be added to adjust pH (4.3 – 5.3). PRESERVATIVE ADDED: Chlorobutanol 1%.
