Respiratory Depression:
Hydromorphone hydrochloride produces dose-related respiratory depression by acting directly on brain stem respiratory centers. Hydromorphone hydrochloride also affects centers that control respiratory rhythm, and may produce irregular and periodic breathing.
Head Injury and Increased Intracranial Pressure:
The respiratory depressant effects of narcotics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a preexisting increase in intracranial pressure. Furthermore, narcotics produce effects which may obscure the clinical course of patients with head injuries.
Acute Abdominal Conditions:
The administration of narcotics may obscure the diagnosis or clinical course of patients with acute abdominal conditions.
There is currently no manufacturer warning information available for this drug.
Hydromorphone hydrochloride is indicated for the relief of moderate to severe pain such as that due to:
|
|
Hydromorphone hydrochloride (WARNING: May be habit forming), a hydrogenated ketone of morphine, is a narcotic analgesic. It is available in:
Suppositories (for rectal administration) containing:
The structural formula of hydromorphone hydrochloride is:
M.W. 321.8