Always provide Client Information Sheet with prescription. Administer an initial dosage of 3.25 mg/kg (1.48 mg/lb) body weight, orally every other day (see Table 1). Dose reductions of 0.5 mg/kg (to a minimum dose of 2.2 mg/kg (1.0 mg/lb) every other day) and dose interruptions (cessation of PALLADIA for up to two weeks) may be utilized, if needed, to manage adverse reactions (see Table 2 as well as Warnings and Precautions). Adjust dose based on approximately weekly veterinary assessments for the first 6 weeks and approximately every 6 weeks, thereafter. PALLADIA may be administered with or without food. Do not split tablets.
Table 1. 3.25 mg/kg Dose Chart
Dog Body Weight
Number of Tablets
Pounds
Kilograms
Dose
10 mg
15 mg
50 mg
11.0 – 11.8
5.0 - 5.3
15 mg
1
11.9 – 15.2
5.4 - 6.9
20 mg
2
15.3 – 18.5
7.0 - 8.4
25 mg
1
1
18.6 – 22.0
8.5 - 10.0
30 mg
2
22.1 – 25.4
10.1 - 11.5
35 mg
2
1
25.5 – 28.7
11.6 - 13.0
40 mg
1
2
28.8 – 32.2
13.1 - 14.6
45 mg
3
32.3 – 35.5
14.7 - 16.1
50 mg
1
35.6 – 38.8
16.2 - 17.6
55 mg
1
3
38.9 – 42.3
17.7 - 19.2
60 mg
1
1
42.4 – 45.6
19.3 - 20.7
65 mg
1
1
45.7 – 50.7
20.8 - 23.0
70 mg
2
1
50.8 – 59.3
23.1 - 26.9
80 mg
2
1
59.4 – 65.9
27.0 - 29.9
95 mg
3
1
66.0 – 71.2
30.0 - 32.3
100 mg
2
71.3 – 76.3
32.4 - 34.6
110 mg
1
2
76.4 – 79.6
34.7 - 36.1
115 mg
1
2
79.7 – 84.7
36.2 - 38.4
120 mg
2
2
84.8 – 94.8
38.5 - 43.0
130 mg
2
2
94.9 – 105.0
43.1 - 47.6
150 mg
3
105.1 – 110.0
47.7 - 49.9
160 mg
1
3
110.1 – 113.5
50.0 - 51.5
165 mg
1
3
113.6 – 118.6
51.6 - 53.8
170 mg
2
3
118.7 – 128.8
53.9 - 58.4
180 mg
2
3
128.9 – 138.9
58.5 - 63.0
200 mg
4
139.0 – 144.0
63.1 - 65.3
210 mg
1
4
144.1 – 157.6
65.4 - 71.5
215 mg
1
4
157.7 – 173.1
71.6 - 78.5
250 mg
5
173.2 – 177.9
78.6 - 80.7
260 mg
1
5
178.0 – 191.6
80.8 - 86.9
265 mg
1
5
191.7 – 220.5
87.0 - 100.0
300 mg
6
Table 2. Dose Modification Based on Toxicity Observed
Toxicity
Dose Adjustment
Neutropenia
>1000/µL
Maintain dose level
≤1000/µL or neutropenic fever or infection
Stop drug until >1000/µL and clinical signs normal; then decrease dose by 0.5 mg/kg
Renal Toxicities (Creatinine)
<2.0 mg/dL
Maintain dose level
≥2.0 mg/dL
Stop drug until <2.0 mg/dL then decrease dose by 0.5 mg/kg
Albumin
<1.5 g/dL
Stop drug until >2.5 g/dL then decrease dose by 0.5 mg/kg
Hematocrit
<26%
Stop drug until >30% then decrease dose by 0.5 mg/kg
Diarrhea
<4 watery stools/day for less than 2 days
Maintain dose level and institute supportive care
≥4 watery stools/day or ≥ 2 days
Stop drug until formed stools and institute supportive care. When dosing is resumed, decrease dose by 0.5 mg/kg
GI Bleeding
Fresh blood in stool or black tarry stool for > 2 days or frank hemorrhage or blood clots in stool.
Stop drug and institute supportive care until resolution of all clinical signs of blood in stool, then decrease dose by 0.5 mg/kg.
