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Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
The topical corticosteroids constitute a class of primarily synthetic steroids used as antiinflammatory and anti-pruritic agents. Hydrocortisone is included in this class of synthetic corticosteroid.
Chemically, hydrocortisone is Pregn-4-ene-3,20-dione,11,17,21-trihydroxy-,(11ß)- its molecular formula is C21H30O5; its molecular weight is 362.46; its Chemical Abstract Service (CAS) registry number is 50-23-7; and its structural formula is:
Each gram of Hydrocortisone Cream USP 1% provides 10 mg of hydrocortisone in a nonstaining water washable cream base consisting of stearyl alcohol, glyceryl monostearate, polyoxyl 40 stearate, isopropyl palmitate, paraffin, sorbitan monostearate, glycerin, lactic acid, potassium sorbate and purified water.
Each gram of Hydrocortisone Ointment USP 1% provides 10 mg of hydrocortisone in a white petrolatum base.