DOSAGE: Tri-Heart® Plus ivermectin/pyrantel chewable tablets should be administered orally at monthly intervals at the
recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as
pamoate salt) per kg (2.27 mg/Ib) of body weight. The recommended dosing schedule for prevention of canine
heartworm disease and for the treatment and control of ascarids and hookworms is as follows:
Dog Weight
Chewable Tablets
per Month
Ivermectin
Content
Pyrantel
Content
Color Coding on
Blister Card and Carton
Up to 25 lbs.
1
68 mcg
57 mg
Blue
26 to 50 lbs.
1
136 mcg
114 mg
Green
51 to 100 lbs.
1
272 mcg
227 mg
Brown
Tri-Heart® Plus ivermectin/pyrantel chewable tablets are recommended for dogs 6 weeks of
age and older. For dogs over 100 lbs, use the appropriate combination of these tablets.
ADMINISTRATION: Remove only one chewable tablet at a time from the blister card.
Because most dogs find Tri-Heart®t Plus chewable tablets palatable, the product can be
offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food
or placed in the back of the dog’s mouth for forced swallowing.
Care should be taken that the dog consumes the complete dose, and treated animals should
be observed for a few minutes after administration to ensure that part of the dose is not lost
or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Tri-Heart® Plus chewable tablets should be given at monthly intervals during the period of the
year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active.
The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes.
The final dose must be given within a month (30 days) after the dog’s last exposure
to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive
program, the first dose of Tri-Heart® Plus chewable tablets must be given within a month (30
days) of the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be
reduced. Therefore, for optimal performance, the chewable tablet must be given once a
month on or about the same day of the month. If treatment is delayed, whether by a few days
or many, immediate treatment with Tri-Heart® Plus chewable tablets and resumption of the
recommended dosing regimen minimizes the opportunity for the development of adult
heartworms.
Monthly treatment with Tri-Heart® Plus chewable tablets also provides effective treatment
and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala,
A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with
intestinal parasites.
