
WARNINGS
Avoid contact with the eyes or mucous membranes. Exercise care when applying Zithranol-RR cream to the face or intertriginous skin areas. Discontinue use if a sensitivity reaction occurs or if excessive irritation develops.
There is currently no manufacturer warning information available for this drug.
INDICATIONS AND USAGE
For the topical treatment of patients with stable plaque psoriasis.
DESCRIPTION
Zithranol-RR contains 1.2% microcrystalline encapsulated anthralin in a green aqueous cream base containing glyceryl monolaurate, glyceryl monomyristate, citric acid, sodium hydroxide, FD&C Blue No. 1 and purified water. The anthralin in Zithranol-RR is microencapsulated into a proprietary formulation of surface active crystalline polar lipids to provide for rapid release, as well as to reduce irritation and staining frequently observed with nonencapsulated anthralin preparations. Since the monoglycerides comprising the microcrystalline matrix have significant antimicrobial properties, Zithranol-RR is resistant to microbial contamination or overgrowth without the need for a preservative agent. The chemical name of anthralin is 1,8-dihydroxy-9-anthrone and its structural formula is:
