Aloxi

2.1 Recommended Dosing

Dosage for Adults - one 0.5 mg capsule administered approximately one hour prior to the start of chemotherapy. ALOXI can be taken with or without food.

2.1 Recommended Dosing

Chemotherapy Induced Nausea and Vomiting

Dosage for Adults - a single 0.25 mg I.V. dose administered over 30 seconds. Dosing should occur approximately 30 minutes before the start of chemotherapy.

Postoperative Nausea and Vomiting

Dosage for Adults - a single 0.075 mg I.V. dose administered over 10 seconds immediately before induction of anesthesia.

2.2 Instructions for I.V. Administration

ALOXI is supplied ready for intravenous injection. ALOXI should not be mixed with other drugs. Flush the infusion line with normal saline before and after administration of ALOXI.

Parenteral drug products should be inspected visually for particulate matter and discoloration before administration, whenever solution and container permit.

2.1 Recommended Dosing

Chemotherapy-Induced Nausea and Vomiting

Age Dose* Infusion Time Adults 0.25 mg x 1

Infuse over 30 seconds beginning approx.
30 min before the start of chemo

Pediatrics
(1 month to less than 17 years)

20 micrograms per
kilogram (max 1.5 mg) x 1

Infuse over 15 minutes beginning approx.
30 min before the start of chemo

*Note different dosing units in pediatrics

Postoperative Nausea and Vomiting
Dosage for Adults - a single 0.075 mg intravenous dose administered over 10 seconds immediately before the induction of anesthesia.

2.2 Instructions for Intravenous Administration

ALOXI is supplied ready for intravenous administration at a concentration of 0.05 mg/mL (50 mcg/ mL). ALOXI should not be mixed with other drugs. The infusion line should be flushed with normal saline before and after administration of ALOXI. Parenteral drug products should be inspected visually for particulate matter and discoloration before administration, whenever solution and container permit.