Directions for Dilution
Antizol-Vet® is supplied as a sterile concentrate. If the Antizol-Vet® solution has solidified in the vial, the solution should be liquefied by running the vial under warm water or holding it in the hand. Solidification does not affect the efficacy, safely, or stability of Antizol-Vet®. The intravenous dose should be prepared aseptically by withdrawing the entire contents of the Antizol-Vet® (fomepizole) for injection vial into a syringe containing 28.5 mL of sterile 0.9% sodium chloride. Shake the solution very well to mix. Inspect visually for particulate matter prior to administration. Store the diluted solution at room temperature. DISCARD ANY UNUSED SOLUTION 72 HOURS FOLLOWING DILUTION.
Directions for Dosing
Following dilution, Antizol-Vet® should be administered intravenously over five to ten minutes. An initial loading dose of 20 mg/kg should be administered intravenously (IV) as soon as practical upon suspicion of ethylene glycol poisoning (use Table 1 below to determine the number of mL to inject). At 12, 24, and 36 hours following the initial loading dose of Antizol-Vet®, doses of 15, 15, and 5 mg/kg, respectively, should be administered. If the animal has not recovered following this regimen and there is a suspicion or documentation of remaining ethylene glycol in the bloodstream of the affected animal, the practitioner should continue to dose the animal with 5 mg/kg every 12 hours until ethylene glycol is undetectable in the bloostream or the animal has visibly recovered.
TABLE 1 Volume of diluted (50 mg/kg) Antizol-Vet® needed to dose a dog of the following body weights at the indicated dose
Animal body weight (kg)
Inject IV at:
Initial loading dose
12 and 24 hours after initial dose
36 hours after initial dose
1 Kg = 2.2 Lbs.
Milliliters of diluted Antizol-Vet® needed for a dose of
20 mg/kg
Milliliters of diluted Antizol-Vet® needed for a dose of
15 mg/kg
Milliliters of diluted Antizol-Vet® needed for a dose of
5 g/kg
5
2.0 mL
1.5 mL
0.5 mL
10
4.0 mL
3.0 mL
1.0 mL
15
6.0 mL
4.5 mL
1.5 mL
20
8.0 mL
6.0 mL
2.0 mL
25
10.0 mL
7.5 mL
2.5 mL
30
12.0 mL
9.0 mL
3.0 mL
35
14.0 mL
10.5 mL
3.5 mL
40
16.0mL
12.0 mL
4.0 mL
45
18.0 mL
13.5 mL
4.5 mL
50
20.0 mL
15.0 mL
5.0 mL
55
22.0 mL
16.5 mL
5.5 mL
60
24.0 mL
18.0mL
6.0 mL
65
26.0 mL
19.5 mL
6.5 mL
70
28.0 mL
21.0 mL
7.0 mL
Example calculation: Use the 50 mg/mL solution of diluted Antizol-Vet
® for the 20 mg/kg dose. The number of milliliters of the reconstituted Antizol-Vet
® needed for an animal weighting 7.6 kg =
20 mg/kg (dose required) x 7.6 kg (body weight in kg)
—————————————————————-——— = 3.04 mL
50 mg/mL (Antizol-Vet® concentration)
Additional Therapy
Supportive care to correct fluid, acid-base, and electrolyte imbalances may also be necessary. If ingestion of antifreeze is witnessed, vomiting should be induced. Gastric lavage with activated charcoal is indicated within 1 to 2 hours of ingestion; beyond this time, the procedure is of little benefit.
