Acyclovir ointment 5 % is intended for cutaneous use only and should not be used in the eye.
There is currently no manufacturer warning information available for this drug.
Acyclovir ointment 5 % is indicated in the management of initial genital herpes and in limited non-life-threatening mucocutaneous Herpes simplex virus infections in immunocompromised patients.
Acyclovir is a synthetic nucleoside analogue active against herpes viruses. Acyclovir Ointment 5 % is a formulation for topical administration. Each gram of acyclovir ointment 5 % contains 50 mg of acyclovir in a polyethylene glycol (PEG) base.
Acyclovir is a white, crystalline powder with the molecular formula C8H11N5O3 and a molecular weight of 225. The maximum solubility in water at 37°C is 2.5 mg/mL. The pka’s of acyclovir are 2.27 and 9.25.
The chemical name of acyclovir is 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one; it has the following structural formula: