Dexdomitor

DOSAGE AND ADMINISTRATION:

Dogs: Sedation and Analgesia: 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 intravenously (IV). Preanesthesia: 125 or 375 mcg/m2 IM.

The choice of preanesthetic dose depends on the duration and severity of the procedure, as well as the anesthetic regime. The following two tables may be used to determine the correct dexmedetomidine dosage. Note that the mcg/kg dosage decreases as body weight increases. For example, dogs weighing 2 kg are dosed at 28.1 mcg/kg dexmedetomidine IV, compared to dogs weighing 80 kg that are dosed at 8.7 mcg/kg. Due to the small volume of administration, accurate dosing is not possible in dogs weighing less than 2 kg (4.4 lb).

Table 1: CANINE SEDATION/ANALGESIA DOSE TABLE: Intravenous (IV) and intramuscular (IM) dosing on the basis of body weight. DEXDOMITOR 0.5 mg/mL Sedation/analgesia in dogs Dog
Weight Dexmedetomidine
375 mcg/m2 IV Dexmedetomidine
500 mcg/m2 IM lbs Kg mcg/kg mL mcg/kg mL 4.4-7 2-3 28.1 0.12 40 0.15 7.1-9 3.1-4 25 0.15 35 0.2 9.1-11 4.1-5 23 0.2 30 0.3 11.1-22 5.1-10 19.6 0.29 25 0.4 22.1-29 10.1-13 16.8 0.38 23 0.5 29.1-33 13.1-15 15.7 0.44 21 0.6 33.1-44 15.1-20 14.6 0.51 20 0.7 44.1-55 20.1-25 13.4 0.6 18 0.8 55.1-66 25.1-30 12.6 0.69 17 0.9 66.1-73 30.1-33 12 0.75 16 1 73.1-81 33.1-37 11.6 0.81 15 1.1 81.1-99 37.1-45 11 0.9 14.5 1.2 99.1-110 45.1-50 10.5 0.99 14 1.3 110.1-121 50.1-55 10.1 1.06 13.5 1.4 121.1-132 55.1-60 9.8 1.13 13 1.5 132.1-143 60.1-65 9.5 1.19 12.8 1.6 143.1-154 65.1-70 9.3 1.26 12.5 1.7 154.1-176 70.1-80 9 1.35 12.3 1.8 >176 >80 8.7 1.42 12 1.9 Table 2: CANINE PREANESTHESIA DOSE TABLE: Intramuscular (IM) dosing on the basis of body weight. DEXDOMITOR 0.5 mg/mL Preanesthesia in dogs Dog
Weight Dexmedetomidine
125 mcg/m2 IM Dexmedetomidine
375 mcg/m2 IM lbs Kg mcg/kg mL mcg/kg mL 4.4-7 2-3 9.4 0.04 28.1 0.12 7.1-9 3.1-4 8.3 0.05 25 0.15 9.1-11 4.1-5 7.7 0.07 23 0.2 11.1-22 5.1-10 6.5 0.1 19.6 0.29 22.1-29 10.1-13 5.6 0.13 16.8 0.38 29.1-33 13.1-15 5.2 0.15 15.7 0.44 33.1-44 15.1-20 4.9 0.17 14.6 0.51 44.1-55 20.1-25 4.5 0.2 13.4 0.6 55.1-66 25.1-30 4.2 0.23 12.6 0.69 66.1-73 30.1-33 4 0.25 12 0.75 73.1-81 33.1-37 3.9 0.27 11.6 0.81 81.1-99 37.1-45 3.7 0.3 11 0.9 99.1-110 45.1-50 3.5 0.33 10.5 0.99 110.1-121 50.1-55 3.4 0.35 10.1 1.06 121.1-132 55.1-60 3.3 0.38 9.8 1.13 132.1-143 60.1-65 3.2 0.4 9.5 1.19 143.1-154 65.1-70 3.1 0.42 9.3 1.26 154.1-176 70.1-80 3 0.45 9 1.35 >176 >80 2.9 0.47 8.7 1.42

The use of dexmedetomidine as a preanesthetic markedly reduces anesthetic requirements in dogs. Injectable induction drug requirements for intubation will be reduced between 30% and 60%, depending on the choice of anesthetic and the dexmedetomidine preanesthetic dose. The concentration of inhalation maintenance anesthetic will be reduced between 40% and 60%, depending on the dose of dexmedetomidine. The anesthetic dose should always be titrated against the response of the patient. The choice of anesthetic is left to the discretion of the veterinarian.

Cats: Sedation, Analgesia and Preanesthesia: 40 mcg/kg intramuscularly (IM).

This dose can also be used as a preanesthetic and has been shown to markedly reduce anesthetic requirements in cats. Injectable anesthetic drug requirements for intubation were reduced up to 49%, depending on the choice of induction drug. The concentration of inhalation maintenance anesthetic was reduced between 35% and 44%, depending on the choice of induction drug. The anesthetic dose should always be titrated against the response of the patient.

The following table may be used to determine the correct dexmedetomidine dosage for cats based on body weight.

Table 3: FELINE DOSE TABLE: Intramuscular (IM) dosing on the basis of body weight in cats. DEXDOMITOR 0.5 mg/mL Sedation/analgesia and preanesthesia in cats Cat
Weight Dexmedetomidine
40 mcg/kg IM lbs kg mcg/kg mL 2-4 1-2 40 0.1 4.1-7 2.1-3 40 0.2 7.1-9 3.1-4 40 0.3 9.1-13 4.1-6 40 0.4 13.1-15 6.1-7 40 0.5 15.1-18 7.1-8 40 0.6 18.1-22 8.1-10 40 0.7

It is recommended that dogs and cats be fasted for 12 hours before treatment with DEXDOMITOR. An eye lubricant should be applied to cats to prevent corneal desiccation that may result from a reduction in the blink reflex. Following injection of DEXDOMITOR, the animal should be allowed to rest quietly for 15 minutes; sedation and analgesia occur within 5 to 15 minutes, with peak effects at 30 minutes after dexmedetomidine.

DOSAGE AND ADMINISTRATION:

Dogs: Sedation and Analgesia: 500 mcg/m2 intramuscularly (IM) or 375 mcg/m2 intravenously (IV). Preanesthesia: 125 or 375 mcg/m2 IM.

The choice of preanesthetic dose depends on the duration and severity of the procedure, as well as the anesthetic regime. The following two tables may be used to determine the correct dexmedetomidine dosage. Note that the mcg/kg dosage decreases as body weight increases. For example, dogs weighing 2 kg are dosed at 28.1 mcg/kg dexmedetomidine IV, compared to dogs weighing 80 kg that are dosed at 8.7 mcg/kg. Due to the small volume of administration, accurate dosing is not possible in dogs weighing less than 2 kg (4.4 lb).

Table 1: CANINE SEDATION/ANALGESIA DOSE TABLE: Intravenous (IV) and intramuscular (IM) dosing on the basis of body weight. DEXDOMITOR 0.1 mg/mL Sedation/analgesia in dogs Dog
Weight Dexmedetomidine
375 mcg/m2 IV Dexmedetomidine
500 mcg/m2 IM lbs Kg mcg/kg mL mcg/kg mL 4.4-7 2-3 28.1 0.6 40 0.75 7.1-9 3.1-4 25 0.75 35 1 9.1-11 4.1-5 23 1 30 1.5 11.1-22 5.1-10 19.6 1.45 25 2 22.1-29 10.1-13 16.8 1.9

For higher weight ranges, use DEXDOMITOR's higher concentration and its associated dosing chart.

Table 2: CANINE PREANESTHESIA DOSE TABLE: Intramuscular (IM) dosing on the basis of body weight. DEXDOMITOR 0.1 mg/mL Preanesthesia in dogs Dog
Weight Dexmedetomidine
125 mcg/m2 IM Dexmedetomidine
375 mcg/m2 IM lbs Kg mcg/kg mL mcg/kg mL 4.4-7 2-3 9.4 0.2 28.1 0.6 7.1-9 3.1-4 8.3 0.25 25 0.75 9.1-11 4.1-5 7.7 0.35 23 1 11.1-22 5.1-10 6.5 0.5 19.6 1.45 22.1-29 10.1-13 5.6 0.65 16.8 1.9 29.1-33 13.1-15 5.2 0.75 33.1-44 15.1-20 4.9 0.85

For higher weight ranges, use DEXDOMITOR's higher concentration and its associated dosing chart.

The use of dexmedetomidine as a preanesthetic markedly reduces anesthetic requirements in dogs. Injectable induction drug requirements for intubation will be reduced between 30% and 60%, depending on the choice of anesthetic and the dexmedetomidine preanesthetic dose. The concentration of inhalation maintenance anesthetic will be reduced between 40% and 60%, depending on the dose of dexmedetomidine. The anesthetic dose should always be titrated against the response of the patient. The choice of anesthetic is left to the discretion of the veterinarian.

Cats: Sedation, Analgesia and Preanesthesia: 40 mcg/kg intramuscularly (IM).

This dose can also be used as a preanesthetic and has been shown to markedly reduce anesthetic requirements in cats. Injectable anesthetic drug requirements for intubation were reduced up to 49%, depending on the choice of induction drug. The concentration of inhalation maintenance anesthetic was reduced between 35% and 44%, depending on the choice of induction drug. The anesthetic dose should always be titrated against the response of the patient.

The following table may be used to determine the correct dexmedetomidine dosage for cats based on body weight.

Table 3: FELINE DOSE TABLE: Intramuscular (IM) dosing on the basis of body weight in cats. DEXDOMITOR 0.1 mg/mL Sedation/analgesia and preanesthesia in cats Cat
Weight Dexmedetomidine
40 mcg/kg IM lbs kg mcg/kg mL 2-4 1-2 40 0.5 4.1-7 2.1-3 40 1

For higher weight ranges, use DEXDOMITOR's higher concentration and its associated dosing chart.

It is recommended that dogs and cats be fasted for 12 hours before treatment with DEXDOMITOR. An eye lubricant should be applied to cats to prevent corneal desiccation that may result from a reduction in the blink reflex. Following injection of DEXDOMITOR, the animal should be allowed to rest quietly for 15 minutes; sedation and analgesia occur within 5 to 15 minutes, with peak effects at 30 minutes after dexmedetomidine.