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Questions & Answers

Side Effects & Adverse Reactions

Increasing depth of anesthesia with AERRANE (isoflurane, USP) may increase hypotension and respiratory depression. The electroencephalographic pattern associated with deep anesthesia is characterized by burst suppression, spiking, and isoelectric periods.4

Since levels of anesthesia may be altered easily and rapidly, only vaporizers producing predictable percentage concentrations of isoflurane should be used (see DOSAGE AND ADMINISTRATION).

The action of nondepolarizing relaxants is augmented by isoflurane. Less than the usual amounts of these drugs should be used. If the usual amounts of nondepolarizing relaxants are given, the time for recovery from myoneural blockade will be longer in the presence of isoflurane than in the presence of other commonly used anesthetics. Not for use in horses intended for food.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


AERRANE (isoflurane, USP) is used for induction and maintenance of general anesthesia in horses and dogs.


There is currently no drug history available for this drug.

Other Information

AERRANE (isoflurane, USP) is a nonflammable, nonexplosive general inhalation anesthetic agent.  Its chemical name is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is:

Structural Formula

Each mL contains 99.9% isoflurane.

Some  physical constants are:

Molecular weight

Boiling point at 760 mmHg

48.5°C (uncorr.)
Refractive i n d e x n 20/D
Specific gravity 25°/25°C

Vapor pressure in mmHg**
20°C           238

25°C           295

30°C           367

35°C           450
**Equation for vapor pressure calculation:
log 10P vap = A + B/T

          where: A = 8.056
          B = -1664.58
          T = °C + 273.16 (Kelvin)

Partition coefficients at 37°C

Partition coefficients at 25°C - rubber and plastic

Conductive rubber/gas
Butyl rubber/gas
Polyvinyl chloride/gas
Butyl acetate/gas
Purity by gas chromatography
Lower limit of flammability in oxygen
or nitrous oxide at 9 joules/sec. and 23°C
Lower limit of flammability in
oxygen or nitrous oxide at
900 joules/sec. and 23°C
Greater than useful
concentration in

MAC (Minimum Alveolar Concentration) is 1.31% in horses1 and 1.28 in dogs6.

Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures), and does not attack aluminum, tin, brass, iron or copper.

Aerrane Manufacturers

  • Baxter Healthcare Corporation
    Aerrane (Isoflurane) Inhalant [Baxter Healthcare Corporation]

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