Allopurinol

Allopurinol

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Questions & Answers

Side Effects & Adverse Reactions

ALLOPURINOL SHOULD BE DISCONTINUED AT THE FIRST APPEARANCE OF SKIN RASH OR OTHER SIGNS WHICH MAY INDICATE AN ALLERGIC REACTION. In some instances a skin rash may be followed by more severe hypersensitivity reactions such as exfoliative, urticarial, and purpuric lesions, as well as Stevens-Johnson syndrome (erythema multiforme exudativum), and/or generalized vasculitis, irreversible hepatotoxicity and, on rare occasions, death.

In patients receiving PURINETHOL® (mercaptopurine) or IMURAN® (azathioprine), the concomitant administration of 300 to 600 mg of allopurinol per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine. Subsequent adjustment of doses of mercaptopurine or azathioprine should be made on the basis of therapeutic response and the appearance of toxic effects (see CLINICAL PHARMACOLOGY).

A few cases of reversible clinical hepatotoxicity have been noted in patients taking allopurinol, and in some patients, asymptomatic rises in serum alkaline phosphatase or serum transaminase have been observed. If anorexia, weight loss, or pruritus develop in patients on allopurinol, evaluation of liver function should be part of their diagnostic workup. In patients with pre-existing liver disease, periodic liver function tests are recommended during the early stages of therapy.

Due to the occasional occurrence of drowsiness, patients should be alerted to the need for due precaution when engaging in activities where alertness is mandatory.

The occurrence of hypersensitivity reactions to allopurinol may be increased in patients with decreased renal function receiving thiazides and allopurinol concurrently. For this reason, in this clinical setting, such combinations should be administered with caution and patients should be observed closely.

 

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

THIS IS NOT AN INNOCUOUS DRUG. IT IS NOT RECOMMENDED FOR THE TREATMENT OF ASYMPTOMATIC HYPERURICEMIA.

Allopurinol reduces serum and urinary uric acid concentrations. Its use should be individualized for each patient and requires an understanding of its mode of action and pharmacokinetics (see CLINICAL PHARMACOLOGY, CONTRAINDICATIONS, WARNINGS, and PRECAUTIONS).

Allopurinol is indicated in:

  1. the management of patients with signs and symptoms of primary or secondary gout (acute attacks, tophi, joint destruction, uric acid lithiasis, and/or nephropathy).
  2. the management of patients with leukemia, lymphoma and malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels. Treatment with allopurinol should be discontinued when the potential for overproduction of uric acid is no longer present.
  3. the management of patients with recurrent calcium oxalate calculi whose daily uric acid excretion exceeds 800 mg/day in male patients and 750 mg/day in female patients. Therapy in such patients should be carefully assessed initially and reassessed periodically to determine in each case that treatment is beneficial and that the benefits outweigh the risks.

 

History

There is currently no drug history available for this drug.

Other Information

Allopurinol has the following structural formula:

MM1

Allopurinol is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one. It is a xanthine oxidase inhibitor which is administered orally. Each scored white tablet contains 100 mg allopurinol and the inactive ingredients colloidal silicon dioxide, lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate. Each scored orange tablet contains 300 mg allopurinol and the inactive ingredients colloidal silicon dioxide, FD&C Yellow No. 6 Lake, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. Its solubility in water at 37°C is 80 mg/dL and is greater in an alkaline solution.

 

Allopurinol Manufacturers


  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Blenheim Pharmacal, Inc.
    Allopurinol Tablet [Blenheim Pharmacal, Inc.]
  • Proficient Rx Lp
    Allopurinol Tablet [Proficient Rx Lp]
  • Golden State Medical Supply, Inc.
    Allopurinol Tablet [Golden State Medical Supply, Inc.]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Northwind Pharmaceuticals, Llc
    Allopurinol Tablet [Northwind Pharmaceuticals, Llc]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Allopurinol Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • A-s Medication Solutions Llc
    Allopurinol Tablet [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Allopurinol Tablet [A-s Medication Solutions Llc]
  • Mutual Pharmaceutical
    Allopurinol Tablet [Mutual Pharmaceutical]
  • Rebel Distributors Corp.
    Allopurinol Tablet [Rebel Distributors Corp.]
  • Physicians Total Care, Inc.
    Allopurinol Tablet [Physicians Total Care, Inc.]
  • State Of Florida Doh Central Pharmacy
    Allopurinol Tablet [State Of Florida Doh Central Pharmacy]
  • Watson Laboratories, Inc.
    Allopurinol Tablet [Watson Laboratories, Inc.]
  • Lake Erie Medical Dba Quality Care Products Llc
    Allopurinol Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Allopurinol Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Remedyrepack Inc.
    Allopurinol (Allopurinol) Tablet [Remedyrepack Inc. ]
  • Dr. Reddy’s Laboratories Limited
    Allopurinol Tablet, Coated [Dr. Reddy’s Laboratories Limited]
  • Ipca Laboratories Limited
    Allopurinol Tablet [Ipca Laboratories Limited]
  • Remedyrepack Inc.
    Allopurinol (Allopurinol) Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Allopurinol (Allopurinol) Tablet [Remedyrepack Inc. ]
  • Major Pharmaceuticals
    Allopurinol Tablet, Coated [Major Pharmaceuticals]
  • Pd-rx Pharmaceuticals, Inc.
    Allopurinol Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Unit Dose Services
    Allopurinol Tablet [Unit Dose Services]
  • Stat Rx Usa Llc
    Allopurinol Tablet [Stat Rx Usa Llc]
  • Unit Dose Services
    Allopurinol Tablet, Coated [Unit Dose Services]
  • Mckesson Contract Packaging
    Allopurinol Tablet [Mckesson Contract Packaging]
  • Aphena Pharma Solutions – Tennessee, Inc.
    Allopurinol Tablet [Aphena Pharma Solutions – Tennessee, Inc.]
  • Preferred Pharmaceuticals, Inc.
    Allopurinol Tablet [Preferred Pharmaceuticals, Inc.]
  • Major Pharmaceuticals
    Allopurinol Tablet [Major Pharmaceuticals]
  • Bryant Ranch Prepack
    Allopurinol Tablet [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Allopurinol Tablet [Bryant Ranch Prepack]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Mylan Institutional Inc.
    Allopurinol Tablet [Mylan Institutional Inc.]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Allopurinol Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Qualitest Pharmaceuticals
    Allopurinol Tablet [Qualitest Pharmaceuticals]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • A-s Medication Solutions Llc
    Allopurinol Tablet [A-s Medication Solutions Llc]
  • Northstar Rxllc
    Allopurinol Tablet [Northstar Rxllc]
  • Lake Erie Medical Dba Quality Care Products Llc
    Allopurinol Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Clinical Solutions Wholesale
    Allopurinol Tablet [Clinical Solutions Wholesale]
  • Ranbaxy Pharmaceuticals Inc.
    Allopurinol Tablet [Ranbaxy Pharmaceuticals Inc.]
  • Cardinal Health
    Allopurinol Tablet [Cardinal Health]
  • Cardinal Health
    Allopurinol Tablet [Cardinal Health]
  • Accord Healthcare Inc.
    Allopurinol (Allopurinol) Tablet Allopurinol (Allopurinol) Tablet [Accord Healthcare Inc.]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Aidarex Pharmaceuticals Llc
    Allopurinol Tablet [Aidarex Pharmaceuticals Llc]
  • American Health Packaging
    Allopurinol Tablet [American Health Packaging]
  • Pd-rx Pharmaceuticals, Inc.
    Allopurinol Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]
  • Mylan Pharmaceuticals Inc.
    Allopurinol Tablet [Mylan Pharmaceuticals Inc.]
  • Preferred Pharmaceuticals, Inc.
    Allopurinol Tablet [Preferred Pharmaceuticals, Inc.]
  • Preferred Pharmaceuticals, Inc.
    Allopurinol Tablet, Coated [Preferred Pharmaceuticals, Inc.]
  • St Marys Medical Park Pharmacy
    Allopurinol Tablet [St Marys Medical Park Pharmacy]
  • St Marys Medical Park Pharmacy
    Allopurinol (Allopurinol) Tablet [St Marys Medical Park Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Allopurinol Tablet [State Of Florida Doh Central Pharmacy]
  • Cardinal Health
    Allopurinol Tablet [Cardinal Health]
  • Remedyrepack Inc.
    Allopurinol Tablet [Remedyrepack Inc. ]

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