Aloxi

Aloxi

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Questions & Answers

Side Effects & Adverse Reactions

There is currently no warning information available for this product. We apologize for any inconvenience.

Legal Issues

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FDA Safety Alerts

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Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

1.1 Prevention of Chemotherapy-Induced Nausea and Vomiting

ALOXI Capsules are indicated for:

  • Moderately emetogenic cancer chemotherapy - prevention of acute nausea and vomiting associated with initial and repeat courses

History

There is currently no drug history available for this drug.

Other Information

ALOXI (palonosetron HCl) Capsules is an antiemetic and antinauseant agent. It is a serotonin subtype 3 (5-HT3) receptor antagonist with a strong binding affinity for this receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1H-benz[de]isoquinoline hydrochloride. The empirical formula is C19H24N2O.HCl, with a molecular weight of 332.87. Palonosetron hydrochloride exists as a single isomer and has the following structural formula:

Structural Formula

Palonosetron hydrochloride is a white to off-white crystalline powder. It is freely soluble in water, soluble in propylene glycol, and slightly soluble in ethanol and 2-propanol.

Each light beige opaque soft gelatin ALOXI Capsule contains 0.56 mg of palonosetron HCl equivalent to palonosetron 0.5 mg. Inactive ingredients are: mono- and di-glycerides of capryl/capric acid, glycerin, polyglyceryl oleate, water, and butylated hydroxyanisole.

Aloxi Manufacturers


  • Eisai
    Aloxi (Palonosetron Hydrochloride) Capsule, Gelatin Coated [Eisai]
  • Mgi Pharma
    Aloxi (Palonosetron Hydrochloride) Injection [Mgi Pharma]
  • Eisai Inc.
    Aloxi (Palonosetron Hydrochloride) Injection [Eisai Inc.]

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