Aminosyn Rf

Aminosyn Rf

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Questions & Answers

Side Effects & Adverse Reactions

Intravenous infusion of amino acids may induce a rise in blood urea nitrogen (BUN), especially in patients with impaired hepatic or renal function. Appropriate laboratory tests should be performed periodically and infusion discontinued or nitrogen content reduced if BUN levels continue to rise inappropriately.

Administration of nitrogen in any form to patients with marked hepatic insufficiency may result in serum amino acid imbalances or CNS complications. Aminosyn-RF 5.2%, Sulfite-Free, (an amino acid injection — renal formula), therefore, should be used with caution in such patients.

Solutions containing acetate ion should be used with great care in patients with metabolic or respiratory alkalosis.

Hyperammonemia is of special significance in infants, as it can result in mental retardation. Therefore, it is essential that blood ammonia levels be measured frequently in infants.

Aminosyn-RF 5.2% does not replace dialysis and conventional supportive therapy in patients with renal failure.

WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


Aminosyn-RF 5.2%, Sulfite-Free, (an amino acid injection — renal formula) is indicated only as an adjunct to management of patients with potentially reversible acute renal failure who are unable to eat. When infused with hypertonic dextrose as a source of calories and with added appropriate electrolytes and vitamins, Aminosyn-RF 5.2% is suitable as an intravenous source of protein in a parenteral nutritional regimen for such patients.


There is currently no drug history available for this drug.

Other Information

Aminosyn®-RF 5.2%, Sulfite-Free, (an amino acid injection — renal formula) is a sterile, nonpyrogenic solution for intravenous infusion. Aminosyn-RF 5.2% is oxygen sensitive. The solution contains the following crystalline amino acids:

mg/100 mL

Min. Daily

Need (mg**)

Essential Amino Acids







Lysine Acetate*


















Nonessential Amino Acids







*Amount cited is for Lysine alone and does not include the acetate salt.

**The minimum daily quantities needed to maintain nitrogen balance in the healthy adult. (Rose, W.C., The Sequence of Events Leading to the Establishment of the Amino Acid Needs of Man, Am J. Public Health, 58:2020, 1968.)

***Histidine is considered essential for patients in renal failure.

Electrolytes and Product Characteristics



Acetate (C2H3O2)a (mEq/Liter)


Protein Equivalent (approx. grams/liter)


Total Nitrogen (grams/liter)


Osmolarity (mOsmol/liter)


pH (Range)

5.2 (4.5 to 6.0b)

a Includes acetate from acetic acid used in processing and from Lysine acetate.

b Adjusted with acetic acid.

Each 500 mL represents three Rose Units of essential amino acids plus arginine and histidine.

The formulas for the individual amino acids present in Aminosyn-RF 5.2% are as follows:

Essential Amino Acids

Isoleucine, USP


Leucine, USP


Lysine Acetate, USP

(C6H14N2O2 • CH3COOH)

Methionine, USP


Phenylalanine, USP


Threonine, USP


Tryptophan, USP


Valine, USP


Nonessential Amino Acids

Arginine, USP


Histidine, USP


The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.

Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.

Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

Aminosyn Rf Manufacturers

  • Hospira, Inc.
    Aminosyn Rf (Isoleucine, Leucine, Lysine Acetate, Methionine, Phenylalanine, Threonine, Tryptophan, Valine, Arginine, And Histidine) Injection, Solution [Hospira, Inc.]

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