Ammonia N 13

Ammonia N 13

Ammonia N 13 Recall

Get an alert when a recall is issued.

Questions & Answers

Side Effects & Adverse Reactions

There is currently no warning information available for this product. We apologize for any inconvenience.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


Ammonia N 13 Injection is indicated for diagnostic Positron Emission Tomography (PET) imaging of the
myocardium under rest or pharmacologic stress conditions to evaluate myocardial perfusion in patients
with suspected or existing coronary artery disease.


There is currently no drug history available for this drug.

Other Information

11.1 Chemical Characteristics
Ammonia N 13 Injection is a positron emitting radiopharmaceutical that is used for diagnostic purposes
in conjunction with positron emission tomography (PET) imaging. The active ingredient, [13N] ammonia,
has the molecular formula of 13NH3 with a molecular weight of 16.02, and has the following chemical

N13 Chemical Charcteristics

Ammonia N 13 Injection is provided as a ready to use sterile, pyrogen-free, clear and colorless solution.
Each mL of the solution contains between 0.138 GBq to 1.387 GBq (3.75 mCi to 37.5mCi) of [13N]
ammonia, at the end of synthesis (EOS) reference time, in 0.9% aqueous sodium chloride. The pH of the
solution is between 4.5 to 7.5. The recommended dose of radioactivity (10-20 mCi) is associated with a
theoretical mass dose of 0.5-1.0 picomoles (8.47-16.94 picograms) of ammonia.
11.2 Physical Characteristics
Nitrogen N13 decays by emitting positron to Carbon C13 (stable) and has a physical half-life of 9.96
minutes. The principal photons useful for imaging are the dual 511 keV gamma photons that are
produced and emitted simultaneously in opposite direction when the positron interacts with an electron
(Table 2).
Table 2: Principal Radiation Emission Data for Nitrogen 13
Radiation/Emission %Per Disintegration Energy
Positron(β+) 100 1190 keV (Max.)
Gamma(±)* 200 511 keV
*Produced by positron annihilation
The specific gamma ray constant (point source air kerma coefficient) for nitrogen N13 is 5.9 R/hr/mCi
(1.39 x 10-6 Gy/hr/kBq) at 1 cm. The half-value layer (HVL) of lead (Pb) for 511 keV photons is 4 mm.
Selected coefficients of attenuation are listed in Table 3 as a function of lead shield thickness. For
example, the use of 39 mm thickness of lead will attenuate the external radiation by a factor of about
Table 3: Radiation Attenuation of 511 keV Photons by lead (Pb) shielding
Shield Thickness (Pb) mm Coefficient of Attenuation
4 0.5
8 0.25
13 0.1
26 0.01
39 0.001
52 0.0001
Table 4 lists fractions remaining at selected time intervals from the calibration time. This information may
be used to correct for physical decay of the radionuclide.
Table 4: Physical Decay Chart for Nitrogen N 13
Minutes Fraction Remaining
0* 1.000
5 0.706
10 0.499
15 0.352
20 0.249
25 0.176
30 0.124
*Calibration time

Ammonia N 13 Manufacturers

  • Spectron Mrc, Llc
    Ammonia N 13 Injection [Spectron Mrc, Llc]
  • Global Isotopes, Llc D/b/a Zevacor Molecular
    Ammonia N 13 Injection [Global Isotopes, Llc D/b/a Zevacor Molecular]
  • Petnet Solutions, Inc.
    Ammonia N 13 (Ammonia N-13) Injection [Petnet Solutions, Inc.]
  • Houston Cyclotron Partners Lp Dba Cyclotope
    Ammonia N 13 (Ammonia N-13) Injection [Houston Cyclotron Partners Lp Dba Cyclotope]
  • Iba Molecular North America Inc.
    Ammonia N 13 (Ammonia N-13) Injection [Iba Molecular North America Inc.]
  • Mayo Clinic
    Ammonia N 13 (Ammonia N-13) Injection, Solution [Mayo Clinic]
  • Shertech Laboratories, Llc
    Ammonia N 13 (Ammonia N-13) Injection [Shertech Laboratories, Llc]
  • Washington University School Of Medicine
    Ammonia N 13 (Nh3n13) Injection [Washington University School Of Medicine]
  • Ucsf Radiopharmaceutical Facility
    Ammonia N 13 (Nh3n13) Injection [Ucsf Radiopharmaceutical Facility]
  • Kreitchman Pet Center
    Ammonia N 13 (Ammonia N-13) Injection [Kreitchman Pet Center]
  • The Feinstein Institute For Medical Research
    Ammonia N 13 (Nh3n13) Injection [The Feinstein Institute For Medical Research]
  • University Of California, Los Angeles
    Ammonia N 13 (Ammonia N-13) Injection [University Of California, Los Angeles]
  • The Johns Hopkins University
    Ammonia N 13 (Nh3n13) Injection [The Johns Hopkins University]

Login To Your Free Account