Ammonium Molybdate
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Questions & Answers
Side Effects & Adverse Reactions
- Molybdenum has been reported to promote the mobilization of tissue copper, and increase urinary excretion of copper both in humans and animals. Excessive amounts of Molybdenum can therefore produce copper deficiency. The metabolism of copper in patients receiving Molybdenum supplements in TPN solution should be frequently checked.
- Purine and sulfur metabolic profiles should be frequently carried out in patients receiving molybdenum supplements in TPN solutions.
- Ammonium Molybdate Injection, USP is a hypotonic solution and should be administered in admixtures only.
This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.
Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Ammonium Molybdate Injection, USP is indicated for use as a supplement to TPN solutions. Administration of Molybdenum in TPN solutions helps to prevent depletion of endogenous stores and subsequent deficiency symptoms.
History
There is currently no drug history available for this drug.
Other Information
Ammonium Molybdate Injection, USP is a sterile, nonpyrogenic solution for use as an additive to solutions for Total Parenteral Nutrition (TPN). Each mL contains Ammonium Molybdate Tetrahydrate (NH4)6MO7O24•4H2O, 46 mcg and Water for Injection q.s. Each mL provides 25 mcg of Molybdenum. Ammonium Hydroxide and/or Hydrochloric Acid may have been added to adjust pH.
Sources
Ammonium Molybdate Manufacturers
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American Regent, Inc.
![Ammonium Molybdate Injection, Solution [American Regent, Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Ammonium Molybdate | American Regent, Inc.
Ammonium Molybdate Injection, USP provides 25 mcg molybdenum/mL. For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 120 mcg molybdenum/day. For pediatric patients, the additive dosage level should be calculated by extrapolation.
In an adult, molybdenum deficiency state resulting from prolonged TPN support, intravenous administration of molybdenum as ammonium molybdate at 163 mcg/day for 21 days has been reported to reverse deficiency symptoms without toxicity.
Aseptic addition of Ammonium Molybdate Injection, USP to TPN solutions under a laminar flow hood is recommended. Molybdenum is physically compatible with the electrolytes and other trace elements usually present in amino acid/dextrose solutions used for TPN. Monitoring of sulfur and purine metabolism is suggested as a guideline. Since copper and molybdenum are antagonistic to each other, frequent monitoring of blood copper levels should be carried out during molybdenum TPN supplementation.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.
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