Anagrelide Hydrochloride

Anagrelide Hydrochloride

Anagrelide Hydrochloride Recall

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Questions & Answers

Side Effects & Adverse Reactions


Anagrelide should be used with caution in patients with known or suspected heart disease, and only if the potential benefits of therapy outweigh the potential risks. Because of the positive inotropic effects and side effects of anagrelide, a pre-treatment cardiovascular examination is recommended along with careful monitoring during treatment. In humans, therapeutic doses of anagrelide may cause cardiovascular effects, including vasodilation, tachycardia, palpitations, and congestive heart failure.


Exposure to anagrelide is increased 8 fold in patients with moderate hepatic impairment (see CLINICAL PHARMACOLOGY). Use of anagrelide in patients with severe hepatic impairment has not been studied. The potential risks and benefits of anagrelide therapy in a patient with mild and moderate impairment of hepatic function should be assessed before treatment is commenced. In patients with moderate hepatic impairment, dose reduction is required and patients should be carefully monitored for cardiovascular effects (see DOSAGE AND ADMINISTRATION for specific dosing recommendations).

Interstitial Lung Diseases

Interstitial lung diseases (including allergic alveolitis, eosinophilic pneumonia and interstitial pneumonitis) have been reported to be associated with the use of anagrelide in postmarketing reports. Most cases presented with progressive dyspnea with lung infiltrations. The time of onset ranged from 1 week to several years after initiating anagrelide. In most cases, the symptoms improved after discontinuation of anagrelide (see ADVERSE REACTIONS).

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.


Anagrelide hydrochloride capsules are indicated for the treatment of patients with thrombocythemia, secondary to myeloproliferative disorders, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events (see CLINICAL STUDIES, DOSAGE AND ADMINISTRATION).


There is currently no drug history available for this drug.

Other Information

Anagrelide hydrochloride is an off white powder that is very slightly soluble in water and sparingly soluble in dimethyl sulfoxide and in dimethylformamide. Anagrelide hydrochloride is a platelet-reducing agent with a chemical name of 6,7-dichloro-1,5-dihydroimidazo[2,1-b] quinazolin-2(3H)-one monohydrochloride monohydrate, and it has the following structural formula:

Structural Formula

C10H7Cl2N3O·HCl·H2O M.W. 310.55

Each anagrelide hydrochloride capsule, for oral administration, contains either 0.5 mg or 1 mg of anagrelide base (as anagrelide hydrochloride) and has the following inactive ingredients: black iron oxide, crospovidone, D&C yellow #10 aluminum lake, FD&C blue #1/brilliant blue aluminum lake, FD&C blue #2/indigo carmine aluminum lake, FD&C red #40/allura red aluminum lake, gelatin, lactose anhydrous, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, propylene glycol, shellac glaze and titanium dioxide.

Anagrelide Hydrochloride Manufacturers

  • Physicians Total Care, Inc.
    Anagrelide Hydrochloride Capsule [Physicians Total Care, Inc.]
  • Ivax Pharmaceuticals, Inc.
    Anagrelide Hydrochloride Capsule [Ivax Pharmaceuticals, Inc.]
  • Carilion Materials Management
    Anagrelide Hydrochloride Capsule [Carilion Materials Management]

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