Anascorp
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Uses
Anascorp® [Centruroides (Scorpion) Immune F(ab')2 (Equine) Injection] is an equine-derived antivenom indicated for treatment of patients with clinical signs of scorpion envenomation.
History
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Other Information
Anascorp [Centruroides (Scorpion) Immune F(ab')2 (Equine) Injection] is a sterile nonpyrogenic, lyophilized, polyvalent preparation of equine immune globulin F(ab')2 fragments, manufactured from plasma of horses immunized with with venom of C. noxius, C.l. limpidus, C.l. tecomanus, and C.s.suffusus. The product is obtained by pepsin digestion of horse plasma to remove the Fc portion of immune globulin, followed by fractionation and purification steps. The F(ab')2 content is not less than 85%, F(ab) content is not more than 7%, and the product contains less than 5% intact immunoglobulin. Each vial of Anascorp contains 45-80 milligrams of sodium chloride, 4.3 - 38.3 milligrams of sucrose, and 6.6-94.9 milligrams of glycine as stabilizers. Trace amounts of pepsin, cresol (< 0.41 mg/vial), borates (< 1 mg/vial) and Sulfates (< 1.7 mg/vial) may be present from the manufacturing process. Each vial contains no more than 120 milligrams of protein and will be neutralize at least 150 LD50 of Centruroides scorpion venom in a mouse neutralization assay.
The manufacturing procedures that contribute to the reduction of risk of viral transmission include pepsin digestion, ammonium sulfate precipitation/heat treatment and nanofiltration.
Sources
Anascorp Manufacturers
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Rare Disease Therapeutics, Inc
![Anascorp (Centruroides (Scorpion) Immune F(Ab)2 (Equine)) Injection, Powder, Lyophilized, For Solution [Rare Disease Therapeutics, Inc]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Anascorp | Rare Disease Therapeutics, Inc
For Intravenous use only.
Initiate treatment with Anascorp as soon as possible after scorpion sting in patients who develop clinically important signs of scorpion envenomation, including but not limited to loss of muscle control, roving or abnormal eye movements, slurred speech, respiratory distress, excessive salivation, frothing at the mouth and vomiting.(2)
Initial Dose: 3 vials
The initial dose of Anascorp is 3 vials. Reconstitute the contents of each vial with 5 milliliters of sterile normal saline and mix by continuous gentle swirling. Combine the contents of the reconstituted vials promptly and further dilute to a total volume of 50 milliliters with sterile normal saline. Inspect the solution visually for particulate matter and discoloration prior to administration. Do not use if turbid. Infuse intravenously over 10 minutes. Monitor patient closely during and up to 60 minutes following the completion of infusion to determine if clinically important signs of envenomation have resolved. Discard partially used vials.Initial Dose: 3 vials
Additional doses may be used if needed. Infuse one vial at a time at intervals of 30 to 60 minutes. Reconstitute the contents with 5 milliliters of sterile normal saline and mix by continuous gentle swirling. Further dilute to a total volume of 50 milliliters with sterile normal saline. Inspect the solution visually for particulate matter or discoloration prior to administration. Infuse intravenously over 10 minutes. Monitor patient closely during and up to 60 minutes following the completion of infusion to determine if clinically important signs of envenomation have resolved. Discard partially used vials.
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