FDA records indicate that there are no current recalls for this drug.
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Questions & Answers
Side Effects & Adverse Reactions
This drug should not be administered to domestic food-producing animals.
Not for use in horses intended for food.
Avoid accidental administration to humans. Should such exposure occur, notify a physician immediately. Artificial respiration may be indicated.
In Cervidae, occasional capture-associated deaths occur. Clinical trials reveal a mortality rate of approximately 3.5% attendant with the administration of xylazine.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Xylazine should be used in horses and Cervidae (Fallow Deer, Mule Deer, Sika Deer, White-Tailed Deer and Elk) when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia.
Horses: Xylazine has been used successfully as follows:
- Diagnostic procedures — oral and ophthalmic examinations, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radiographic examinations.
- Orthopedic procedures, such as application of casting materials and splints.
- Dental procedures.
- Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations.
- To calm and facilitate handling of fractious animals.
Major surgical procedures:- When used as a preanesthetic to general anesthesia.
- When used in conjunction with local anesthetics.
Cervidae: Xylazine may be used for the following:
- To calm and facilitate handling of fractious animals.
- Diagnostic procedures.
- Minor surgical procedures.
- Therapeutic medication for sedation and relief of pain following injury or surgery.
- As a preanesthetic to local anesthesia, AnaSed® LA at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine.
History
There is currently no drug history available for this drug.
Other Information
AnaSed® LA is supplied in 50 mL multipledose vials as a sterile solution.
EACH ML CONTAINS: Xylazine hydrochloride equivalent to 100 mg of base activity, methylparaben 0.9 mg, propylparaben 0.1 mg, sodium citrate dihydrate 5.0 mg and water for injection. pH adjusted with citric acid and sodium citrate.
Protect from heat. Do not store over 30° C (86° F).
Sources
Anased La Manufacturers
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Vetone
Anased La | Vetone
Dosage
Horses:
Intravenous — 0.5 mL/100 lb body weight (0.5 mg/lb or 1.1 mg/kg).
Intramuscular — 1.0 mL/100 lb body weight (1 mg/lb or 2.2 mg/kg).
Cervidae:
Administer intramuscularly, by either hand syringe or syringe dart, in the heavy muscles of the croup or shoulder.
Fallow Deer (Dama dama) — 2.0 to 4.0 mL/100 lbs body weight (2.0 to 4.0 mg/lb or 4.4 to 8.8 mg/kg).
Mule Deer (Odocoileus hemionus) — 1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb or 2.2 to 4.4 mg/kg).
Sika Deer (Cervus nippon) — 1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb or 2.2 to 4.4 mg/kg).
White-Tailed Deer (Odocoileus virginianus) — 1.0 to 2.0 mL/100 lbs body weight (1.0 to 2.0 mg/lb or 2.2 to 4.4 mg/kg).
Elk (Cervus canadensis) — 0.25 to 0.5 mL/100 lbs body weight (0.25 to 0.5 mg/lb or 0.55 to 1.1 mg/kg).
Following injection of xylazine, the animal should be allowed to rest quietly until the full effect has been reached.
These dosages produce sedation which is usually maintained for 1 to 2 hours, and analgesia which lasts for 15 to 30 minutes. Preanesthetic to Local Anesthesia
Xylazine at the recommended dosages can be used in conjunction with local anesthetics, such as procaine or lidocaine. Preanesthetic to General Anesthesia Xylazine at the recommended dosage rates produces an additive effect to central nervous system depressants such as pentobarbital sodium, thiopental sodium and thiamylal sodium. Therefore, the dosage of such compounds should be reduced and administered to the desired effect. In general, only 1/3 to 1/2 of the calculated dosage of the barbiturates will be needed to produce a surgical plane of anesthesia. Post-anesthetic or emergence excitement has not been observed in animals preanesthetized with xylazine.Xylazine has been used successfully as a preanesthetic agent for pentobarbital sodium, thiopental sodium, thiamylal sodium, nitrous oxide, ether, halothane, glyceryl guaiacolate and methoxyflurane anesthesia.
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