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Brimonidine tartrate ophthalmic solution 0.2% is indicated for lowering intraocular pressure in patients with open-angle glaucoma or ocular hypertension. The lOP lowering efficacy of brimonidine tartrate ophthalmic solution 0.2% diminishes over time in some patients. This loss of effect appears with a variable time of onset in each patient and should be closely monitored.
Brimonidine Tartrate Ophthalmic Solution 0.2% is a relatively selective alpha-2 adrenergic agonist for ophthalmic use. In solution, brimonidine tartrate ophthalmic solution 0.2% has a clear, greenish-yellow color. It has an osmolality of 280-330 mOsml/kg and a pH of 5.6-6.6 The structural formula is:
C11H10BrN5 • C4H6O6
Mol. Wt. 442.24 (as the tartrate salt)
Chemical Name: 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate.
CAS Number 59803-98-4
Each mL Contains:
ACTIVE: Brimonidine tartrate: 0.2% (2 mg/mL).
INACTIVES: Citric Acid, Polyvinyl Alcohol, Sodium Chloride, Sodium Citrate, Purified Water. Hydrochloric Acid and/or Sodium Hydroxide may be added to adjust pH.
PRESERVATIVE ADDED: Benzalkonium Chloride (0.05 mg).