Calcium Gluconate

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Calcium Gluconate Recall

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Side Effects & Adverse Reactions

For intravenous use only. Subcutaneous or intramuscular injection may cause severe necrosis and sloughing.

WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.

Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

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Legal Issues

There is currently no legal information available for this drug.

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FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

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Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

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FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

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Uses

Calcium Gluconate Injection, USP is used to treat conditions arising from calcium deficiencies such as hypocalcemic tetany, hypocalcemia related to hypoparathyroidism and hypocalcemia due to rapid growth or pregnancy. It is also used in the treatment of black widow spider bites to relieve muscle cramping and as an adjunct in the treatment of rickets, osteomalacia, lead colic and magnesium sulfate overdosage. Calcium gluconate has also been employed to decrease capillary permeability in allergic conditions, nonthrombocytopenic purpura and exudative dermatoses such as dermatitis herpetiformis and for pruritus of eruptions caused by certain drugs. In hyperkalemia, calcium gluconate may aid in antagonizing the cardiac toxicity, provided the patient is not receiving digitalis therapy.

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History

There is currently no drug history available for this drug.

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Other Information

Calcium Gluconate Injection, USP is a sterile, nonpyrogenic, supersaturated solution of calcium gluconate for intravenous use only.

Each mL contains: Calcium gluconate 94 mg; calcium saccharate (tetrahydrate) 4.5 mg; water for injection q.s. Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (6.0 to 8.2).

Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium gluconate.

Each 10 mL of the injection provides 93 mg elemental calcium (Ca++) equivalent to 1 g of calcium gluconate.

The structural formula is:

Sources

Calcium Gluconate Manufacturers

Remedyrepack Inc.

Calcium Gluconate | Remedyrepack Inc.

The dose is dependent on the requirements of the individual patient. Intravenous calcium gluconate injection must be administered slowly.

Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants—Not more than 200 mg (not more than 2 mL)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

No Recall
Remedyrepack Inc.

Calcium Gluconate | Remedyrepack Inc.

The dose is dependent on the requirements of the individual patient. Intravenous calcium gluconate injection must be administered slowly.

Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants—Not more than 200 mg (not more than 2 mL)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

No Recall
Fresenius Kabi Usa, Llc

Calcium Gluconate | Fresenius Kabi Usa, Llc

The dose is dependent on the requirements of the individual patient. Intravenous calcium gluconate injection must be administered slowly.
Usual Dosage
Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants— Not more than 200 mg (not more than 2 mL)
Usual Dosage
Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants— Not more than 200 mg (not more than 2 mL)

No Recall
Fresenius Kabi Usa, Llc

Calcium Gluconate | Fresenius Kabi Usa, Llc

The dose is dependent on the requirements of the individual patient. Intravenous calcium gluconate injection must be administered slowly.
Usual Dosage
Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants—Not more than 200 mg (not more than 2 mL)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Usual Dosage
Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants—Not more than 200 mg (not more than 2 mL)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

No Recall
Mwi/vetone

Calcium Gluconate | Mwi/vetone

Cattle: 250 mL to 500 mL. Administer intravenously or intraperitoneally. Solution should be warmed to body temperature and administered slowly.

This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. Discard any unused portion. Handle under aseptic conditions. If there is no apparent improvement in the animal's condition within 24 hours, consult a veterinarian.

No Recall
Henry Schein

Calcium Gluconate | Henry Schein

Cattle: 250 to 500 mL
Administer intravenously or intraperitoneally. Solution should be warmed to body temperature and administered slowly. This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. It should be handled under strict aseptic conditions. If there is no apparent improvement in the animal's condition within 24 hours, consult a veterinarian.

No Recall
Mwi/vetone

Calcium Gluconate | Mwi/vetone

DOSAGE AND ADMINISTRATION: Cattle: 250 mL to 500 mL. Administer intravenously or intraperitoneally. Solution should be warmed to body temperature and administered slowly.

This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. Discard any unused portion. Handle under aseptic conditions. If there is no apparent improvement in the animal's condition within 24 hours, consult a veterinarian.

No Recall
Agripharm

Calcium Gluconate | Agripharm

Cattle: 250-500 mL

Administer intravenously, intraperitoneally or subcutaneously. If given subcutaneously, divide dosage among several injection sites and massage to aid in absorption.

Solution should be warmed to body temperature and administered slowly. This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. It should be handled under aseptic conditions.

No Recall
American Regent, Inc.

Calcium Gluconate | American Regent, Inc.

Calcium Gluconate should be administered intravenously either directly or by infusion. The dose is dependent upon the individual requirements of the patient. Calcium Gluconate may also be administered by intermittent infusion at a rate not exceeding 200 mg/min, or by continuous infusion.

DIRECTIONS FOR DISPENSING FROM 100 mL PHARMACY BULK PACKAGE - NOT FOR DIRECT INFUSION.

The 100 mL Pharmacy Bulk Package is for use in a Pharmacy Admixture Service only. The 100 mL Pharmacy Bulk Package should be suspended (inverted) by its IV hang label in a laminar flow hood or biological safety cabinet. Prior to entering a Pharmacy Bulk Package remove the flip-off seal and cleanse the rubber closure with a suitable antiseptic agent. Entry into the Pharmacy Bulk Package must be made with a sterile transfer set or other sterile dispensing device and the contents dispensed in aliquots using aseptic technique. Use of a syringe needle is not recommended as it may cause leakage. ANY UNUSED PORTION MUST BE DISCARDED

WITHIN 4 HOURS AFTER INITIAL ENTRY. The date and the time initially opened should be recorded in the space provided on the Pharmacy Bulk Package label.

USUAL DOSAGE:

Adults: 500 mg - 2 grams (5-20 mL)

Children: 200-500 mg (2-5 mL)

Infants: not more than 200 mg (not more than 2 mL)

No Recall
General Injectables & Vaccines, Inc.

Calcium Gluconate | General Injectables & Vaccines, Inc.

Calcium Gluconate should be administered intravenously either directly or by infusion. The dose is dependent upon the individual requirements of the patient. Calcium Gluconate may also be administered by intermittent infusion at a rate not exceeding 200 mg/min, or by continuous infusion.

DIRECTIONS FOR DISPENSING FROM 100 mL PHARMACY BULK PACKAGE - NOT FOR DIRECT INFUSION.

The 100 mL Pharmacy Bulk Package is for use in a Pharmacy Admixture Service only. The 100 mL Pharmacy Bulk Package should be suspended (inverted) by its IV hang label in a laminar flow hood or biological safety cabinet. Prior to entering a Pharmacy Bulk Package remove the flip-off seal and cleanse the rubber closure with a suitable antiseptic agent. Entry into the Pharmacy Bulk Package must be made with a sterile transfer set or other sterile dispensing device and the contents dispensed in aliquots using aseptic technique. Use of a syringe needle is not recommended as it may cause leakage. ANY UNUSED PORTION MUST BE DISCARDED WITHIN 4 HOURS AFTER INITIAL ENTRY. The date and the time initially opened should be recorded in the space provided on the Pharmacy Bulk Package label.

USUAL DOSAGE:

Adults:      500 mg - 2 grams (5-20mL)

Children:   200-500 mg (2-5 mL)

Infants:      not more than 200 mg (not more than 2 mL)

No Recall
App Pharmaceuticals, Llc

Calcium Gluconate | App Pharmaceuticals, Llc

The dose is dependent on the requirements of the individual patient. Intravenous calcium gluconate injection must be administered slowly.
Usual Dosage

Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants—Not more than 200 mg (not more than 2 mL)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Usual Dosage

Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants—Not more than 200 mg (not more than 2 mL)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

No Recall
App Pharmaceuticals, Llc

Calcium Gluconate | App Pharmaceuticals, Llc

The dose is dependent on the requirements of the individual patient. Intravenous calcium gluconate injection must be administered slowly.
Usual Dosage

Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants— Not more than 200 mg (not more than 2 mL)
Usual Dosage

Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants— Not more than 200 mg (not more than 2 mL)

No Recall
Roxane Laboratories, Inc.

Calcium Gluconate | Roxane Laboratories, Inc.

For use as a dietary supplement in adults, take 1 to 16 tablets per day, in divided doses, preferably 1 to 2 hours after meals, or as directed by a physician.

Do not use if printed foil under cap is broken of missing.

Keep bottle tightly closed. Store in a cool, dry place, out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

As with any supplement, if you are pregnant or nursing a baby, contact your healthcare professional.

Questions or Comments?

Call 1-800-962-8364

You may also report serious side effects to this phone number.

No Recall
Cardinal Health

Calcium Gluconate | Cardinal Health

The dose is dependent on the requirements of the individual patient. Intravenous calcium gluconate injection must be administered slowly.
Usual Dosage

Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants—Not more than 200 mg (not more than 2 mL)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Usual Dosage

Adults—500 mg to 2 g (5 to 20 mL)

Pediatric patients—200 to 500 mg (2 to 5 mL)

Infants—Not more than 200 mg (not more than 2 mL)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

No Recall
Bimeda, Inc., Division Of Cross Vetpharm Group

Calcium Gluconate | Bimeda, Inc., Division Of Cross Vetpharm Group

DOSAGE AND ADMINISTRATION:

Cattle: 250 mL to 500 mL. Administer intravenously or intraperitoneally. Solution should be warmed to body temperature and administered slowly. This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. Discard any unused portion. Handle under aseptic conditions.

If there is no apparent improvement in the animal's condition within 24 hours, consult a veterinarian.

EACH 100 mL CONTAINS:

Calcium Gluconate

(provides 2.14 grams Calcium)..........................23 grams

Water for Injection...................................................q.s.

Contains boric acid as a solubilizing agent.

ELECTROLYTES PER 1000 mL:

Calcium 1069 mEq

Osmolarity (calc.) 6,947 m0smol/L

Hypertonic

No Recall
Durvet

Calcium Gluconate | Durvet

Cattle: 250 to 500 mL

Administer intravenously. Solution should be warmed to body temperature and administered slowly. This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. It should be handled under aseptic conditions. If there is no apparent improvement in the animal's condition within 24 hours; consult a veterinarian.

No Recall
Durvet

Calcium Gluconate | Durvet

Cattle: 250 to 500 mL

Administer intravenously. Solution should be warmed to body temperature and administered slowly. This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. It should be handled under aseptic conditions. If there is no apparent improvement in the animal's condition within 24 hours; consult a veterinarian.

No Recall
Vedco

Calcium Gluconate | Vedco

Cattle: 250 to 500 mL

Administer intravenously or intraperitoneally.

Solution should be warmed to body temperature and administered slowly. This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. It should be handled under aseptic conditions. If there is no apparent improvement in the animal's condition within 24 hours, consult a veterinarian.

No Recall
Iba Inc.

Calcium Gluconate | Iba Inc.

Cattle: 250 to 500 mL

Administer intravenously or intraperitoneally. Solution should be warmed to body temperature and administered slowly. This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. it should be handled under aseptic conditions. If there is no apparent improvement in the animal's condition within 24 hours, consult a veterinarian.

No Recall
Animart

Calcium Gluconate | Animart

For intravenous administration only. Cattle: 200-500mL. Dosage may be repeated at 8 to 12 hour intervals if required.

No Recall
Agrilabs

Calcium Gluconate | Agrilabs

Cattle: 250 to 500 mL
Administer intravenously, intraperitoneally or subcutaneously. If given subcutaneously, divide dosage among several injection sites and massage to aid in absorption. Solution should be warmed to body temperature and administered slowly. This product is sterile in unopened container. It contains no preservative. Use entire contents when first opened. It should be handled under aseptic conditions.
If there is no apparent improvement in the animal's condition within 24 hours, consult a vetrinarian.

No Recall
General Injectables & Vaccines, Inc

Calcium Gluconate | General Injectables & Vaccines, Inc

The dose is dependent on the requirements of the individual patient. Intravenous calcium gluconate injection must be administered slowly.

Usual Dosage

Adults-500 mg to 2 g (5 to 20 mL)

Pediatric Patients-200 to 500 mg (2 to 5 mL)

Infants-Not more than 200 mg (not more than 2 mL)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

No Recall
General Injectables & Vaccines, Inc.

Calcium Gluconate | Shopko Stores Operating Co., Llc

• this product does not contain directions or complete warnings for adult use • do not give more than directed (see overdose warning) • shake well before using • mL = milliliter • find right dose on chart. If possible, use weight to dose; otherwise, use age. • push air out of syringe. Insert syringe tip into bottle opening. • flip bottle upside down. Pull yellow part of syringe to the first dose line and then push product back into bottle. • pull yellow part of syringe until it reaches and stays at the correct dose • dispense liquid slowly into child’s mouth, toward inner cheek • repeat dose every 4 hours while symptoms last • do not give more than 5 times in 24 hours • replace cap tightly to maintain child resistance
Dosing Chart

Weight (lb)

Age (yr)

Dose (mL)*

under 24

under 2 years

ask a doctor

24-35

2-3 years

5 mL

* or as directed by a doctor

Attention: use only enclosed syringe specifically designed for use with this product. Do not use any other dosing device.

No Recall