Chlordiazepoxide Hydrochloride And Clidinium Bromide

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Chlordiazepoxide Hydrochloride And Clidinium Bromide Recall

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Side Effects & Adverse Reactions

As in the case of other preparations containing CNS-acting drugs, patients receiving Chlordiazepoxide HCl and Clidinium Bromide Capsules should be cautioned about possible combined effects with alcohol and other CNS depressants. For the same reason, they should be cautioned against hazardous occupations requiring complete mental alertness such as operating machinery or driving a motor vehicle.

Usage in Pregnancy

An increased risk of congenital malformations associated with the use of minor tranquilizers (chlordiazepoxide, diazepam and meprobamate) during the first trimester of pregnancy has been suggested in several studies. Because use of these drugs is rarely a matter of urgency, their use during this period should almost always be avoided. The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered. Patients should be advised that if they become pregnant during therapy or intend to become pregnant they should communicate with their physicians about the desirability of discontinuing the drug.

As with all anticholinergic drugs, an inhibiting effect on lactation may occur (see Animal Pharmacology).

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Legal Issues

There is currently no legal information available for this drug.

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FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

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Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

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FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

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Uses

INDICATIONS AND USAGE: Based on a review of this drug by the National Academy of Sciences – National Research Council and/or other information, FDA has classified the indications as follows:

"Possibly" effective: as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.

Final classiffcation of the less-than-effective indications requires further investigation.

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History

There is currently no drug history available for this drug.

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Other Information

Chlordiazepoxide HCl and Clidinium Bromide combines in a single capsule formulation the antianxiety action of chlordiazepoxide hydrochloride and the anticholinergic/spasmolytic effects of clidinium bromide.

Each Chlordiazepoxide HCl and Clidinium Bromide Capsule contains 5 mg chlordiazepoxide hydrochloride and 2.5 mg clidinium bromide. Each capsule also contains lactose, starch, talc, titanium dioxide, D&C Yellow #10, FD&C Green #3 and gelatin.

Chlordiazepoxide hydrochloride is a versatile, therapeutic agent of proven value for the relief of anxiety and tension. It is indicated when anxiety, tension or apprehension are significant components of the clinical profile. It is among the safer of the effective psychopharmacologic compounds.

Chlordiazepoxide hydrochloride is 7-chloro-2-methylamino-5-phenyl-3H-1, 4-benzodiazepine 4-oxide hydrochloride. A colorless, crystalline substance, it is soluble in water. It is unstable in solution and the powder must be protected from light. The molecular weight is 336.22. The structural formula of chlordiazepoxide hydrochloride is as follows:

Clidinium bromide is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Structurally clidinium bromide is:

Sources

Chlordiazepoxide Hydrochloride And Clidinium Bromide Manufacturers

Macoven Pharmaceuticals

Chlordiazepoxide Hydrochloride And Clidinium Bromide | Macoven Pharmaceuticals

Because of the varied individual responses to tranquilizers and anticholinergics, the optimum dosage of Chlordiazepoxide HCl and Clidinium Bromide Capsules varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects. The usual maintenance dose is 1 or 2 capsules, 3 or 4 times a day administered before meals and at bedtime.
Geriatric Dosing
Dosage should be limited to the smallest effective amount to preclude the development of ataxia, oversedation or confusion. The initial dose should not exceed 2 Chlordiazepoxide HCl and Clidinium Bromide Capsules per day, to be increased gradually as needed and tolerated.

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Eci Pharmaceuticals Llc

Chlordiazepoxide Hydrochloride And Clidinium Bromide | Eci Pharmaceuticals Llc

Because of the varied individual responses to tranquilizers and anticholinergics, the optimum dosage of Chlordiazepoxide HCl and Clidinium Bromide Capsules varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects. The usual maintenance dose is 1 or 2 capsules orally, 3 or 4 times a day administered before meals and at bedtime.
Geriatric Dosing
Dosage should be limited to the smallest effective amount to preclude the development of ataxia, oversedation or confusion. The initial dose should not exceed 2 Chlordiazepoxide HCl and Clidinium Bromide Capsules per day, to be increased gradually as needed and tolerated.

No Recall
Bi-coastal Pharmaceutical Corporation

Chlordiazepoxide Hydrochloride And Clidinium Bromide | Bi-coastal Pharmaceutical Corporation

Because of the varied individual responses to tranquilizers and anticholinergics, the optimum dosage of Chlordiazepoxide HCl and Clidinium Bromide Capsules varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects. The usual maintenance dose is 1 or 2 capsules orally, 3 or 4 times a day administered before meals and at bedtime.
Geriatric Dosing
Dosage should be limited to the smallest effective amount to preclude the development of ataxia, oversedation or confusion. The initial dose should not exceed 2 Chlordiazepoxide HCl and Clidinium Bromide Capsules per day, to be increased gradually as needed and tolerated.

No Recall
Acella Pharmaceuticals, Llc

Chlordiazepoxide Hydrochloride And Clidinium Bromide | Acella Pharmaceuticals, Llc

An individualized dosage of Chlordiazepoxide Hydrochloride and Clidinium Bromide Capsules should be made to achieve the most beneficial results. The usual maintenence dose in one (1) or two (2) capsules, three (3) or four (4) times a day, administered before meals and at bedtime. Geriatric Dosing: Dosage should be irrited to the smallest effective amount to minimize CNS effect and to preclude the develpoment of ataxia, excessive seciation or confusion. The intial dose should not exceed two (2) Chlordiazpoxide Hydrochloride and Clidinium Bromide Capsules per day, to be increased gradually as needed and/or tolerated.

No Recall
Golden State Medical Supply, Inc.

Chlordiazepoxide Hydrochloride And Clidinium Bromide | Golden State Medical Supply, Inc.

An individualized dosage of Chlordiazepoxide HCI and Clidinium Br Capsules should be made to achieve the most beneficial results. The usual maintenance dose is one (1) or two (20 capsules, three (3) or four (4) times a day, administered before meals and at bedtime.
Geriatric Dosing: Dosage should be limited to the smallest effective amount to minimize CNS effect and to preclude the development of ataxia, excessive sedation or confusion. The initial dose should not exceed two (2) Chlordiazepoxide HCI and Clidinium Br Capsules per day, to be increased gradually as needed and/or tolerated.

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A-s Medication Solutions Llc

Chlordiazepoxide Hydrochloride And Clidinium Bromide | A-s Medication Solutions Llc

An individualized dosage of Chlordiazepoxide Hydrochloride and Clidinium Bromide Capsules should be made to achieve the most beneficial results. The usual maintenence dose in one (1) or two (2) capsules, three (3) or four (4) times a day, administered before meals and at bedtime. Geriatric Dosing: Dosage should be irrited to the smallest effective amount to minimize CNS effect and to preclude the develpoment of ataxia, excessive seciation or confusion. The intial dose should not exceed two (2) Chlordiazpoxide Hydrochloride and Clidinium Bromide Capsules per day, to be increased gradually as needed and/or tolerated.

No Recall
Oceanside Pharmaceuticals

Chlordiazepoxide Hydrochloride And Clidinium Bromide | Oceanside Pharmaceuticals

Because of the varied individual responses to tranquilizers and anticholinergics, the optimum dosage of Chlordiazepoxide HCl/Clidinium Bromide varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects. The usual maintenance dose is 1 or 2 capsules, 3 or 4 times a day administered before meals and at bedtime.
Geriatric Dosing
Dosage should be limited to the smallest effective amount to preclude the development of ataxia, oversedation or confusion. The initial dose should not exceed 2 Chlordiazepoxide HCl/Clidinium Bromide capsules per day, to be increased gradually as needed and tolerated.

No Recall
Carilion Materials Management

Chlordiazepoxide Hydrochloride And Clidinium Bromide | Carilion Materials Management

Because of the varied individual responses to tranquilizers and anticholinergics, the optimum dosage of Chlordiazepoxide HCl/Clidinium Bromide varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects. The usual maintenance dose is 1 or 2 capsules, 3 or 4 times a day administered before meals and at bedtime.
Geriatric Dosing
Dosage should be limited to the smallest effective amount to preclude the development of ataxia, oversedation or confusion. The initial dose should not exceed 2 Chlordiazepoxide HCl/Clidinium Bromide capsules per day, to be increased gradually as needed and tolerated.

No Recall